Long acting beta-adrenoceptor agonist

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Long acting beta-adrenoceptor agonists are usually prescribed for moderate to severe persistent asthma patients or patients with COPD. They are designed to replace the shorter acting B2-agonists such as salbutamol, as they have a duration of action of approximately 12 hours in comparison with the 4-6 hour duration of salbutamol, making them ideal candidates for twice-daily administration.

Some currently available long acting beta-adrenoceptor agonists are:

• Salmeterol
• Formoterol
• Bambuterol

Studies are currently underway into ultra-long-acting beta-adrenoceptor agonists which would have a duration of action of 24 hours, allowing for once-daily dosing:^[1]

• Indacaterol

[edit] Footnotes

v • d • e Drugs for obstructive airway diseases: asthma/COPD (R03) Adrenergics, inhalants Short acting β2-agonists: Salbutamol/Levosalbutamol • Fenoterol • Terbutaline • Pirbuterol • Procaterol • Bitolterol • Rimiterol • Carbuterol • Tulobuterol • Reproterol Long acting β2-agonists (LABA): Arformoterol • Bambuterol • Clenbuterol • Formoterol • Salmeterol Ultra LABA: Indacaterol other: Epinephrine • Isoprenaline (Isoproterenol) • Orciprenaline (Metaproterenol) Glucocorticoids Beclometasone • Budesonide • Ciclesonide • Fluticasone • Mometasone Anticholinergics Ipratropium • Tiotropium Mast cell stabilizers Cromoglicate • Nedocromil Xanthines Aminophylline • Theobromine • Theophylline Leukotriene antagonists Montelukast • Pranlukast • Zafirlukast Lipoxygenase inhibitor Zileuton Combination products Budesonide/formoterol • Fluticasone/salmeterol • Ipratropium/salbutamol