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Log page index: User:ProteinBoxBot/PBB_Log_Index
[edit] Protein Status Quick Log - Date: 02:43, 8 November 2007 (UTC)
[edit] Proteins without matches (15)
[edit] Proteins with a High Potential Match (10)
[edit] Created (6)
[edit] Manual Inspection (Page not found) (19)
[edit] Protein Status Grid - Date: 02:43, 8 November 2007 (UTC)
[edit] Vebose Log - Date: 02:43, 8 November 2007 (UTC)
- INFO: Beginning work on ABO... {November 7, 2007 6:09:36 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:10:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:10:43 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ABO_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lz0.
| PDB = {{PDB2|1lz0}}, {{PDB2|1lz7}}, {{PDB2|1lzi}}, {{PDB2|1lzj}}, {{PDB2|1r7t}}, {{PDB2|1r7u}}, {{PDB2|1r7v}}, {{PDB2|1r7x}}, {{PDB2|1r7y}}, {{PDB2|1r80}}, {{PDB2|1r81}}, {{PDB2|1r82}}, {{PDB2|1wsz}}, {{PDB2|1wt0}}, {{PDB2|1wt1}}, {{PDB2|1wt2}}, {{PDB2|1wt3}}, {{PDB2|1xz6}}, {{PDB2|1zhj}}, {{PDB2|1zi1}}, {{PDB2|1zi3}}, {{PDB2|1zi4}}, {{PDB2|1zi5}}, {{PDB2|1ziz}}, {{PDB2|1zj0}}, {{PDB2|1zj1}}, {{PDB2|1zj2}}, {{PDB2|1zj3}}, {{PDB2|1zjo}}, {{PDB2|1zjp}}, {{PDB2|2a8u}}, {{PDB2|2a8w}}, {{PDB2|2i7b}}, {{PDB2|2o1f}}, {{PDB2|2o1g}}, {{PDB2|2o1h}}
| Name = ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
| HGNCid = 79
| Symbol = ABO
| AltSymbols =; A3GALNT; A3GALT1; GTB; NAGAT
| OMIM = 110300
| ECnumber =
| Homologene = 69306
| MGIid =
| GeneAtlas_image1 = PBB_GE_ABO_214504_at_tn.png
| GeneAtlas_image2 = PBB_GE_ABO_216929_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004380 |text = glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity}} {{GNF_GO|id=GO:0004381 |text = fucosylgalactoside 3-alpha-galactosyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016758 |text = transferase activity, transferring hexosyl groups}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030173 |text = integral to Golgi membrane}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006486 |text = protein amino acid glycosylation}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0009058 |text = biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 28
| Hs_Ensembl = ENSG00000175164
| Hs_RefseqProtein = NP_065202
| Hs_RefseqmRNA = NM_020469
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 135120384
| Hs_GenLoc_end = 135140451
| Hs_Uniprot = P16442
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)''', also known as '''ABO''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ALK... {November 7, 2007 6:10:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:11:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Anaplastic lymphoma kinase (Ki-1)
| HGNCid = 427
| Symbol = ALK
| AltSymbols =; CD246; TFG/ALK
| OMIM = 105590
| ECnumber =
| Homologene = 68387
| MGIid = 103305
| GeneAtlas_image1 = PBB_GE_ALK_208211_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ALK_208212_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004714 |text = transmembrane receptor protein tyrosine kinase activity}} {{GNF_GO|id=GO:0004716 |text = receptor signaling protein tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006487 |text = protein amino acid N-linked glycosylation}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007420 |text = brain development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 238
| Hs_Ensembl = ENSG00000171094
| Hs_RefseqProtein = NP_004295
| Hs_RefseqmRNA = NM_004304
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 29269594
| Hs_GenLoc_end = 29997029
| Hs_Uniprot = Q9UM73
| Mm_EntrezGene = 11682
| Mm_Ensembl = ENSMUSG00000055471
| Mm_RefseqmRNA = NM_007439
| Mm_RefseqProtein = NP_031465
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 71774299
| Mm_GenLoc_end = 72508566
| Mm_Uniprot = P97793
}}
}}
'''Anaplastic lymphoma kinase (Ki-1)''', also known as '''ALK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.<ref>{{cite web | title = Entrez Gene: ALK anaplastic lymphoma kinase (Ki-1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=238| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Benharroch D, Meguerian-Bedoyan Z, Lamant L, ''et al.'' |title=ALK-positive lymphoma: a single disease with a broad spectrum of morphology. |journal=Blood |volume=91 |issue= 6 |pages= 2076-84 |year= 1998 |pmid= 9490693 |doi= }}
*{{cite journal | author=Pulford K, Lamant L, Espinos E, ''et al.'' |title=The emerging normal and disease-related roles of anaplastic lymphoma kinase. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 23 |pages= 2939-53 |year= 2005 |pmid= 15583856 |doi= 10.1007/s00018-004-4275-9 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ANPEP... {November 7, 2007 6:11:42 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:12:21 PM PST}
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{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)
| HGNCid = 500
| Symbol = ANPEP
| AltSymbols =; APN; CD13; LAP1; PEPN; gp150
| OMIM = 151530
| ECnumber =
| Homologene = 68163
| MGIid = 96749
| GeneAtlas_image1 = PBB_GE_ANPEP_202888_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004177 |text = aminopeptidase activity}} {{GNF_GO|id=GO:0004179 |text = membrane alanyl aminopeptidase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008237 |text = metallopeptidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005793 |text = ER-Golgi intermediate compartment}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 290
| Hs_Ensembl = ENSG00000166825
| Hs_RefseqProtein = NP_001141
| Hs_RefseqmRNA = NM_001150
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 88129131
| Hs_GenLoc_end = 88159072
| Hs_Uniprot = P15144
| Mm_EntrezGene = 16790
| Mm_Ensembl = ENSMUSG00000039062
| Mm_RefseqmRNA = NM_008486
| Mm_RefseqProtein = NP_032512
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 79695323
| Mm_GenLoc_end = 79715831
| Mm_Uniprot = Q3TB69
}}
}}
'''Alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)''', also known as '''ANPEP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.<ref>{{cite web | title = Entrez Gene: ANPEP alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=290| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DSP... {November 7, 2007 6:12:21 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:12:55 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:13:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DSP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lm5.
| PDB = {{PDB2|1lm5}}, {{PDB2|1lm7}}
| Name = Desmoplakin
| HGNCid = 3052
| Symbol = DSP
| AltSymbols =; DPI; DPII
| OMIM = 125647
| ECnumber =
| Homologene = 37922
| MGIid = 109611
| GeneAtlas_image1 = PBB_GE_DSP_200606_at_tn.png
| Function = {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}}
| Component = {{GNF_GO|id=GO:0001533 |text = cornified envelope}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005882 |text = intermediate filament}} {{GNF_GO|id=GO:0005913 |text = cell-cell adherens junction}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}} {{GNF_GO|id=GO:0030057 |text = desmosome}}
| Process = {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0018149 |text = peptide cross-linking}} {{GNF_GO|id=GO:0030216 |text = keratinocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1832
| Hs_Ensembl = ENSG00000096696
| Hs_RefseqProtein = NP_001008844
| Hs_RefseqmRNA = NM_001008844
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 7486869
| Hs_GenLoc_end = 7531945
| Hs_Uniprot = P15924
| Mm_EntrezGene = 109620
| Mm_Ensembl = ENSMUSG00000054889
| Mm_RefseqmRNA = XM_621314
| Mm_RefseqProtein = XP_621314
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 38203950
| Mm_GenLoc_end = 38206041
| Mm_Uniprot =
}}
}}
'''Desmoplakin''', also known as '''DSP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.<ref>{{cite web | title = Entrez Gene: DSP desmoplakin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1832| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Presland RB, Dale BA |title=Epithelial structural proteins of the skin and oral cavity: function in health and disease. |journal=Crit. Rev. Oral Biol. Med. |volume=11 |issue= 4 |pages= 383-408 |year= 2001 |pmid= 11132762 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FANCA... {November 7, 2007 6:13:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:14:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Fanconi anemia, complementation group A
| HGNCid = 3582
| Symbol = FANCA
| AltSymbols =; FA; FA-H; FA1; FAA; FACA; FAH; FANCH; MGC75158
| OMIM = 607139
| ECnumber =
| Homologene = 108
| MGIid = 1341823
| GeneAtlas_image1 = PBB_GE_FANCA_203805_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FANCA_203806_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0007140 |text = male meiosis}} {{GNF_GO|id=GO:0008584 |text = male gonad development}} {{GNF_GO|id=GO:0008585 |text = female gonad development}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2175
| Hs_Ensembl = ENSG00000187741
| Hs_RefseqProtein = NP_000126
| Hs_RefseqmRNA = NM_000135
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 88331460
| Hs_GenLoc_end = 88410566
| Hs_Uniprot = O15360
| Mm_EntrezGene = 14087
| Mm_Ensembl = ENSMUSG00000032815
| Mm_RefseqmRNA = NM_016925
| Mm_RefseqProtein = NP_058621
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 126154390
| Mm_GenLoc_end = 126204666
| Mm_Uniprot = Q9CS36
}}
}}
'''Fanconi anemia, complementation group A''', also known as '''FANCA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.<ref>{{cite web | title = Entrez Gene: FANCA Fanconi anemia, complementation group A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2175| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GALT... {November 7, 2007 6:15:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:15:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Galactose-1-phosphate uridylyltransferase
| HGNCid = 4135
| Symbol = GALT
| AltSymbols =;
| OMIM = 606999
| ECnumber =
| Homologene = 126
| MGIid = 95638
| Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0008108 |text = UDP-glucose:hexose-1-phosphate uridylyltransferase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006012 |text = galactose metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2592
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000146
| Hs_RefseqmRNA = NM_000155
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 14430
| Mm_Ensembl = ENSMUSG00000036073
| Mm_RefseqmRNA = NM_016658
| Mm_RefseqProtein = NP_057867
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 41944037
| Mm_GenLoc_end = 41947191
| Mm_Uniprot = Q3TQJ2
}}
}}
'''Galactose-1-phosphate uridylyltransferase''', also known as '''GALT''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined.<ref>{{cite web | title = Entrez Gene: GALT galactose-1-phosphate uridylyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2592| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reichardt JK |title=Genetic basis of galactosemia. |journal=Hum. Mutat. |volume=1 |issue= 3 |pages= 190-6 |year= 1993 |pmid= 1301925 |doi= 10.1002/humu.1380010303 }}
*{{cite journal | author=Tyfield L, Reichardt J, Fridovich-Keil J, ''et al.'' |title=Classical galactosemia and mutations at the galactose-1-phosphate uridyl transferase (GALT) gene. |journal=Hum. Mutat. |volume=13 |issue= 6 |pages= 417-30 |year= 1999 |pmid= 10408771 |doi= 10.1002/(SICI)1098-1004(1999)13:6<417::AID-HUMU1>3.0.CO;2-0 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GAST... {November 7, 2007 6:14:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:15:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Gastrin
| HGNCid = 4164
| Symbol = GAST
| AltSymbols =; GAS
| OMIM = 137250
| ECnumber =
| Homologene = 628
| MGIid = 104768
| GeneAtlas_image1 = PBB_GE_GAST_208138_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0006939 |text = smooth muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2520
| Hs_Ensembl = ENSG00000184502
| Hs_RefseqProtein = NP_000796
| Hs_RefseqmRNA = NM_000805
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 37122139
| Hs_GenLoc_end = 37125746
| Hs_Uniprot = P01350
| Mm_EntrezGene = 14459
| Mm_Ensembl = ENSMUSG00000017165
| Mm_RefseqmRNA = NM_010257
| Mm_RefseqProtein = NP_034387
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 100150497
| Mm_GenLoc_end = 100153086
| Mm_Uniprot = Q6GSF5
}}
}}
'''Gastrin''', also known as '''GAST''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17.<ref>{{cite web | title = Entrez Gene: GAST gastrin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2520| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rozengurt E, Walsh JH |title=Gastrin, CCK, signaling, and cancer. |journal=Annu. Rev. Physiol. |volume=63 |issue= |pages= 49-76 |year= 2001 |pmid= 11181948 |doi= 10.1146/annurev.physiol.63.1.49 }}
*{{cite journal | author=Dockray GJ |title=Clinical endocrinology and metabolism. Gastrin. |journal=Best Pract. Res. Clin. Endocrinol. Metab. |volume=18 |issue= 4 |pages= 555-68 |year= 2005 |pmid= 15533775 |doi= 10.1016/j.beem.2004.07.003 }}
*{{cite journal | author=Anlauf M, Garbrecht N, Henopp T, ''et al.'' |title=Sporadic versus hereditary gastrinomas of the duodenum and pancreas: distinct clinico-pathological and epidemiological features. |journal=World J. Gastroenterol. |volume=12 |issue= 34 |pages= 5440-6 |year= 2006 |pmid= 17006979 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GSTA1... {November 7, 2007 6:15:19 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:15:54 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:16:10 PM PST}
- CREATED: Created new protein page: GSTA1 {November 7, 2007 6:16:17 PM PST}
- INFO: Beginning work on GTF2F1... {November 7, 2007 6:16:17 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:16:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:16:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GTF2F1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1f3u.
| PDB = {{PDB2|1f3u}}, {{PDB2|1i27}}, {{PDB2|1j2x}}, {{PDB2|1nha}}, {{PDB2|1onv}}
| Name = General transcription factor IIF, polypeptide 1, 74kDa
| HGNCid = 4652
| Symbol = GTF2F1
| AltSymbols =; BTF4; RAP74; TF2F1; TFIIF
| OMIM = 189968
| ECnumber =
| Homologene = 1585
| MGIid = 1923848
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016251 |text = general RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005674 |text = transcription factor TFIIF complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2962
| Hs_Ensembl = ENSG00000125651
| Hs_RefseqProtein = NP_002087
| Hs_RefseqmRNA = NM_002096
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 6235811
| Hs_GenLoc_end = 6344184
| Hs_Uniprot = P35269
| Mm_EntrezGene = 98053
| Mm_Ensembl = ENSMUSG00000002658
| Mm_RefseqmRNA = NM_133801
| Mm_RefseqProtein = NP_598562
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 56688526
| Mm_GenLoc_end = 56696547
| Mm_Uniprot = Q8R5B7
}}
}}
'''General transcription factor IIF, polypeptide 1, 74kDa''', also known as '''GTF2F1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HSP90B1... {November 7, 2007 6:25:36 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:26:47 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:27:03 PM PST}
- CREATED: Created new protein page: HSP90B1 {November 7, 2007 6:27:10 PM PST}
- INFO: Beginning work on HSPA4... {November 7, 2007 6:16:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:18:43 PM PST}
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{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Heat shock 70kDa protein 4
| HGNCid = 5237
| Symbol = HSPA4
| AltSymbols =; APG-2; HS24/P52; MGC131852; RY; hsp70; hsp70RY
| OMIM = 601113
| ECnumber =
| Homologene = 1624
| MGIid = 1342292
| GeneAtlas_image1 = PBB_GE_HSPA4_208814_at_tn.png
| GeneAtlas_image2 = PBB_GE_HSPA4_208815_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_HSPA4_211015_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006986 |text = response to unfolded protein}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3308
| Hs_Ensembl = ENSG00000170606
| Hs_RefseqProtein = NP_002145
| Hs_RefseqmRNA = NM_002154
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 132415561
| Hs_GenLoc_end = 132468608
| Hs_Uniprot = P34932
| Mm_EntrezGene = 15525
| Mm_Ensembl = ENSMUSG00000020361
| Mm_RefseqmRNA = NM_008300
| Mm_RefseqProtein = NP_032326
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 53103239
| Mm_GenLoc_end = 53143853
| Mm_Uniprot = Q571M2
}}
}}
'''Heat shock 70kDa protein 4''', also known as '''HSPA4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on INPP5D... {November 7, 2007 6:18:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:19:08 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Inositol polyphosphate-5-phosphatase, 145kDa
| HGNCid = 6079
| Symbol = INPP5D
| AltSymbols =; MGC104855; MGC142140; MGC142142; SHIP; SHIP1; SIP-145; hp51CN
| OMIM = 601582
| ECnumber =
| Homologene = 4046
| MGIid = 107357
| Function = {{GNF_GO|id=GO:0004437 |text = inositol or phosphatidylinositol phosphatase activity}} {{GNF_GO|id=GO:0004445 |text = inositol-polyphosphate 5-phosphatase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006796 |text = phosphate metabolic process}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3635
| Hs_Ensembl =
| Hs_RefseqProtein = XP_935053
| Hs_RefseqmRNA = XM_929960
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16331
| Mm_Ensembl = ENSMUSG00000026288
| Mm_RefseqmRNA = NM_010566
| Mm_RefseqProtein = NP_034696
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 89451660
| Mm_GenLoc_end = 89549455
| Mm_Uniprot =
}}
}}
'''Inositol polyphosphate-5-phosphatase, 145kDa''', also known as '''INPP5D''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: INPP5D inositol polyphosphate-5-phosphatase, 145kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3635| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=MacDonald SM, Vonakis BM |title=Association of the Src homology 2 domain-containing inositol 5' phosphatase (SHIP) to releasability in human basophils. |journal=Mol. Immunol. |volume=38 |issue= 16-18 |pages= 1323-7 |year= 2003 |pmid= 12217402 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KPNA6... {November 7, 2007 6:32:54 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:33:52 PM PST}
- CREATED: Created new protein page: KPNA6 {November 7, 2007 6:34:01 PM PST}
- INFO: Beginning work on LRP2... {November 7, 2007 6:19:08 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:19:48 PM PST}
- CREATED: Created new protein page: LRP2 {November 7, 2007 6:19:58 PM PST}
- INFO: Beginning work on MMP8... {November 7, 2007 6:19:58 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:20:37 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:20:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MMP8_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a85.
| PDB = {{PDB2|1a85}}, {{PDB2|1a86}}, {{PDB2|1bzs}}, {{PDB2|1i73}}, {{PDB2|1i76}}, {{PDB2|1jan}}, {{PDB2|1jao}}, {{PDB2|1jap}}, {{PDB2|1jaq}}, {{PDB2|1jh1}}, {{PDB2|1jj9}}, {{PDB2|1kbc}}, {{PDB2|1mmb}}, {{PDB2|1mnc}}, {{PDB2|1zp5}}, {{PDB2|1zs0}}, {{PDB2|1zvx}}, {{PDB2|2oy2}}, {{PDB2|2oy4}}
| Name = Matrix metallopeptidase 8 (neutrophil collagenase)
| HGNCid = 7175
| Symbol = MMP8
| AltSymbols =; CLG1; HNC; PMNL-CL
| OMIM = 120355
| ECnumber =
| Homologene = 22482
| MGIid = 1202395
| GeneAtlas_image1 = PBB_GE_MMP8_207329_at_tn.png
| Function = {{GNF_GO|id=GO:0004222 |text = metalloendopeptidase activity}} {{GNF_GO|id=GO:0004232 |text = interstitial collagenase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008130 |text = neutrophil collagenase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0000270 |text = peptidoglycan metabolic process}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0030574 |text = collagen catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4317
| Hs_Ensembl = ENSG00000118113
| Hs_RefseqProtein = NP_002415
| Hs_RefseqmRNA = NM_002424
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 102088599
| Hs_GenLoc_end = 102100868
| Hs_Uniprot = P22894
| Mm_EntrezGene = 17394
| Mm_Ensembl = ENSMUSG00000005800
| Mm_RefseqmRNA = NM_008611
| Mm_RefseqProtein = NP_032637
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 7558456
| Mm_GenLoc_end = 7568486
| Mm_Uniprot = Q3TAV4
}}
}}
'''Matrix metallopeptidase 8 (neutrophil collagenase)''', also known as '''MMP8''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.<ref>{{cite web | title = Entrez Gene: MMP8 matrix metallopeptidase 8 (neutrophil collagenase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4317| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Chandler S, Miller KM, Clements JM, ''et al.'' |title=Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview. |journal=J. Neuroimmunol. |volume=72 |issue= 2 |pages= 155-61 |year= 1997 |pmid= 9042108 |doi= }}
*{{cite journal | author=Massova I, Kotra LP, Fridman R, Mobashery S |title=Matrix metalloproteinases: structures, evolution, and diversification. |journal=FASEB J. |volume=12 |issue= 12 |pages= 1075-95 |year= 1998 |pmid= 9737711 |doi= }}
*{{cite journal | author=Nagase H, Woessner JF |title=Matrix metalloproteinases. |journal=J. Biol. Chem. |volume=274 |issue= 31 |pages= 21491-4 |year= 1999 |pmid= 10419448 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NPHS1... {November 7, 2007 6:20:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:21:05 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nephrosis 1, congenital, Finnish type (nephrin)
| HGNCid = 7908
| Symbol = NPHS1
| AltSymbols =; CNF; NPHN
| OMIM = 602716
| ECnumber =
| Homologene = 20974
| MGIid = 1859637
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007588 |text = excretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4868
| Hs_Ensembl =
| Hs_RefseqProtein = NP_004637
| Hs_RefseqmRNA = NM_004646
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 54631
| Mm_Ensembl = ENSMUSG00000006649
| Mm_RefseqmRNA = NM_019459
| Mm_RefseqProtein = NP_062332
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 30168485
| Mm_GenLoc_end = 30195968
| Mm_Uniprot = Q925S5
}}
}}
'''Nephrosis 1, congenital, Finnish type (nephrin)''', also known as '''NPHS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Nephrin is a kidney glomerular filtration barrier protein that is an essential component of the interpodocyte-spanning slit diaphragm. Mutations in the nephrin gene are associated with congenital nephrotic syndrome (NPHS1; MIM 256300).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: NPHS1 nephrosis 1, congenital, Finnish type (nephrin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4868| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tryggvason K |title=Nephrin: role in normal kidney and in disease. |journal=Adv. Nephrol. Necker Hosp. |volume=31 |issue= |pages= 221-34 |year= 2002 |pmid= 11692461 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PBEF1... {November 7, 2007 6:30:12 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:31:11 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:31:29 PM PST}
- CREATED: Created new protein page: PBEF1 {November 7, 2007 6:31:36 PM PST}
- INFO: Beginning work on POR... {November 7, 2007 6:21:05 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:21:36 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:21:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_POR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1amo.
| PDB = {{PDB2|1amo}}, {{PDB2|1b1c}}, {{PDB2|1j9z}}, {{PDB2|1ja0}}, {{PDB2|1ja1}}
| Name = P450 (cytochrome) oxidoreductase
| HGNCid = 9208
| Symbol = POR
| AltSymbols =; CPR; CYPOR; DKFZp686G04235; FLJ26468; P450R
| OMIM = 124015
| ECnumber =
| Homologene = 725
| MGIid = 97744
| GeneAtlas_image1 = PBB_GE_POR_208928_at_tn.png
| Function = {{GNF_GO|id=GO:0003958 |text = NADPH-hemoprotein reductase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0010181 |text = FMN binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5447
| Hs_Ensembl = ENSG00000127948
| Hs_RefseqProtein = NP_000932
| Hs_RefseqmRNA = NM_000941
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 75382409
| Hs_GenLoc_end = 75454108
| Hs_Uniprot = P16435
| Mm_EntrezGene = 18984
| Mm_Ensembl = ENSMUSG00000005514
| Mm_RefseqmRNA = NM_008898
| Mm_RefseqProtein = NP_032924
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 135973785
| Mm_GenLoc_end = 136019952
| Mm_Uniprot = Q05DV1
}}
}}
'''P450 (cytochrome) oxidoreductase''', also known as '''POR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.<ref>{{cite web | title = Entrez Gene: POR P450 (cytochrome) oxidoreductase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5447| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Miller WL, Geller DH, Auchus RJ |title=The molecular basis of isolated 17,20 lyase deficiency. |journal=Endocr. Res. |volume=24 |issue= 3-4 |pages= 817-25 |year= 1999 |pmid= 9888582 |doi= }}
*{{cite journal | author=Backes WL, Kelley RW |title=Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes. |journal=Pharmacol. Ther. |volume=98 |issue= 2 |pages= 221-33 |year= 2003 |pmid= 12725870 |doi= }}
*{{cite journal | author=Miller WL, Huang N, Pandey AV, ''et al.'' |title=P450 oxidoreductase deficiency: a new disorder of steroidogenesis. |journal=Ann. N. Y. Acad. Sci. |volume=1061 |issue= |pages= 100-8 |year= 2006 |pmid= 16467261 |doi= 10.1196/annals.1336.012 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PPBP... {November 7, 2007 6:21:56 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:22:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:23:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PPBP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1f9p.
| PDB = {{PDB2|1f9p}}, {{PDB2|1nap}}, {{PDB2|1tvx}}
| Name = Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
| HGNCid = 9240
| Symbol = PPBP
| AltSymbols =; PBP; B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
| OMIM = 121010
| ECnumber =
| Homologene = 48122
| MGIid = 1888712
| GeneAtlas_image1 = PBB_GE_PPBP_214146_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005355 |text = glucose transmembrane transporter activity}} {{GNF_GO|id=GO:0008009 |text = chemokine activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0015758 |text = glucose transport}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5473
| Hs_Ensembl = ENSG00000163736
| Hs_RefseqProtein = NP_002695
| Hs_RefseqmRNA = NM_002704
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 75071622
| Hs_GenLoc_end = 75072764
| Hs_Uniprot = P02775
| Mm_EntrezGene = 57349
| Mm_Ensembl = ENSMUSG00000029372
| Mm_RefseqmRNA = NM_023785
| Mm_RefseqProtein = NP_076274
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 91843718
| Mm_GenLoc_end = 91845263
| Mm_Uniprot =
}}
}}
'''Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)''', also known as '''PPBP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and sythesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells.<ref>{{cite web | title = Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5473| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC40A1... {November 7, 2007 6:34:01 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:34:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 40 (iron-regulated transporter), member 1
| HGNCid = 10909
| Symbol = SLC40A1
| AltSymbols =; FPN1; HFE4; IREG1; MST079; MSTP079; MTP1; SLC11A3
| OMIM = 604653
| ECnumber =
| Homologene = 40959
| MGIid = 1315204
| Function = {{GNF_GO|id=GO:0005381 |text = iron ion transmembrane transporter activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006826 |text = iron ion transport}} {{GNF_GO|id=GO:0006879 |text = cellular iron ion homeostasis}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 30061
| Hs_Ensembl = ENSG00000138449
| Hs_RefseqProtein = NP_055400
| Hs_RefseqmRNA = NM_014585
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 190133563
| Hs_GenLoc_end = 190153858
| Hs_Uniprot = Q9NP59
| Mm_EntrezGene = 53945
| Mm_Ensembl = ENSMUSG00000025993
| Mm_RefseqmRNA = NM_016917
| Mm_RefseqProtein = NP_058613
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 45852630
| Mm_GenLoc_end = 45870079
| Mm_Uniprot = Q3TJ33
}}
}}
'''Solute carrier family 40 (iron-regulated transporter), member 1''', also known as '''SLC40A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pietrangelo A |title=The ferroportin disease. |journal=Blood Cells Mol. Dis. |volume=32 |issue= 1 |pages= 131-8 |year= 2004 |pmid= 14757427 |doi= }}
*{{cite journal | author=Robson KJ, Merryweather-Clarke AT, Cadet E, ''et al.'' |title=Recent advances in understanding haemochromatosis: a transition state. |journal=J. Med. Genet. |volume=41 |issue= 10 |pages= 721-30 |year= 2005 |pmid= 15466004 |doi= 10.1136/jmg.2004.020644 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SPTB... {November 7, 2007 6:23:13 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:24:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:24:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SPTB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1s35.
| PDB = {{PDB2|1s35}}
| Name = Spectrin, beta, erythrocytic (includes spherocytosis, clinical type I)
| HGNCid = 11274
| Symbol = SPTB
| AltSymbols =; HSpTB1
| OMIM = 182870
| ECnumber =
| Homologene = 295
| MGIid = 98387
| GeneAtlas_image1 = PBB_GE_SPTB_208416_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SPTB_214145_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0051015 |text = actin filament binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0008091 |text = spectrin}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0051016 |text = barbed-end actin filament capping}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6710
| Hs_Ensembl = ENSG00000070182
| Hs_RefseqProtein = NP_000338
| Hs_RefseqmRNA = NM_000347
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 64284778
| Hs_GenLoc_end = 64416354
| Hs_Uniprot = P11277
| Mm_EntrezGene = 20741
| Mm_Ensembl = ENSMUSG00000021061
| Mm_RefseqmRNA = NM_013675
| Mm_RefseqProtein = NP_038703
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 77499328
| Mm_GenLoc_end = 77629387
| Mm_Uniprot = Q149M1
}}
}}
'''Spectrin, beta, erythrocytic (includes spherocytosis, clinical type I)''', also known as '''SPTB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bennett V, Baines AJ |title=Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. |journal=Physiol. Rev. |volume=81 |issue= 3 |pages= 1353-92 |year= 2001 |pmid= 11427698 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TBXA2R... {November 7, 2007 6:24:18 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:25:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Thromboxane A2 receptor
| HGNCid = 11608
| Symbol = TBXA2R
| AltSymbols =; TXA2-R
| OMIM = 188070
| ECnumber =
| Homologene = 825
| MGIid = 98496
| GeneAtlas_image1 = PBB_GE_TBXA2R_336_at_tn.png
| GeneAtlas_image2 = PBB_GE_TBXA2R_207554_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_TBXA2R_211590_x_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004960 |text = thromboxane receptor activity}} {{GNF_GO|id=GO:0004961 |text = thromboxane A2 receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007585 |text = respiratory gaseous exchange}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6915
| Hs_Ensembl = ENSG00000006638
| Hs_RefseqProtein = NP_001051
| Hs_RefseqmRNA = NM_001060
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 3545778
| Hs_GenLoc_end = 3557658
| Hs_Uniprot = P21731
| Mm_EntrezGene = 21390
| Mm_Ensembl = ENSMUSG00000034881
| Mm_RefseqmRNA = NM_009325
| Mm_RefseqProtein = NP_033351
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 80731957
| Mm_GenLoc_end = 80738300
| Mm_Uniprot = Q5FW61
}}
}}
'''Thromboxane A2 receptor''', also known as '''TBXA2R''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Namba T, Narumiya S |title=[Thromboxane A2 receptor; structure, function and tissue distribution] |journal=Nippon Rinsho |volume=51 |issue= 1 |pages= 233-40 |year= 1993 |pmid= 8433523 |doi= }}
*{{cite journal | author=Murugappan S, Shankar H, Kunapuli SP |title=Platelet receptors for adenine nucleotides and thromboxane A2. |journal=Semin. Thromb. Hemost. |volume=30 |issue= 4 |pages= 411-8 |year= 2005 |pmid= 15354262 |doi= 10.1055/s-2004-833476 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on U2AF2... {November 7, 2007 6:31:36 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:32:37 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 6:32:48 PM PST}
- CREATED: Created new protein page: U2AF2 {November 7, 2007 6:32:54 PM PST}
- INFO: Beginning work on UBE3A... {November 7, 2007 6:27:10 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:28:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:29:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_UBE3A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1c4z.
| PDB = {{PDB2|1c4z}}, {{PDB2|1d5f}}
| Name = Ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)
| HGNCid = 12496
| Symbol = UBE3A
| AltSymbols =; ANCR; AS; E6-AP; EPVE6AP; FLJ26981; HPVE6A
| OMIM = 601623
| ECnumber =
| Homologene = 7988
| MGIid = 105098
| GeneAtlas_image1 = PBB_GE_UBE3A_211285_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_UBE3A_211575_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_UBE3A_213128_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007420 |text = brain development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7337
| Hs_Ensembl = ENSG00000114062
| Hs_RefseqProtein = NP_000453
| Hs_RefseqmRNA = NM_000462
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 23133489
| Hs_GenLoc_end = 23235221
| Hs_Uniprot = Q05086
| Mm_EntrezGene = 22215
| Mm_Ensembl = ENSMUSG00000025326
| Mm_RefseqmRNA = NM_001033962
| Mm_RefseqProtein = NP_001029134
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 59096621
| Mm_GenLoc_end = 59174596
| Mm_Uniprot = Q3TPQ9
}}
}}
'''Ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)''', also known as '''UBE3A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.<ref>{{cite web | title = Entrez Gene: UBE3A ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7337| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ZFP36... {November 7, 2007 6:29:18 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 6:29:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 6:30:12 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ZFP36_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1m9o.
| PDB = {{PDB2|1m9o}}
| Name = Zinc finger protein 36, C3H type, homolog (mouse)
| HGNCid = 12862
| Symbol = ZFP36
| AltSymbols =; G0S24; GOS24; NUP475; RNF162A; TIS11; TTP
| OMIM = 190700
| ECnumber =
| Homologene = 2558
| MGIid = 99180
| GeneAtlas_image1 = PBB_GE_ZFP36_201531_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003727 |text = single-stranded RNA binding}} {{GNF_GO|id=GO:0003729 |text = mRNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006402 |text = mRNA catabolic process}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0043488 |text = regulation of mRNA stability}} {{GNF_GO|id=GO:0045638 |text = negative regulation of myeloid cell differentiation}} {{GNF_GO|id=GO:0050728 |text = negative regulation of inflammatory response}} {{GNF_GO|id=GO:0050779 |text = RNA destabilization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7538
| Hs_Ensembl = ENSG00000128016
| Hs_RefseqProtein = NP_003398
| Hs_RefseqmRNA = NM_003407
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 44589293
| Hs_GenLoc_end = 44591853
| Hs_Uniprot = P26651
| Mm_EntrezGene = 22695
| Mm_Ensembl = ENSMUSG00000044786
| Mm_RefseqmRNA = NM_011756
| Mm_RefseqProtein = NP_035886
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 28085544
| Mm_GenLoc_end = 28087988
| Mm_Uniprot = Q3TW34
}}
}}
'''Zinc finger protein 36, C3H type, homolog (mouse)''', also known as '''ZFP36''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Blackshear PJ |title=Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover. |journal=Biochem. Soc. Trans. |volume=30 |issue= Pt 6 |pages= 945-52 |year= 2003 |pmid= 12440952 |doi= 10.1042/ }}
*{{cite journal | author=Carrick DM, Lai WS, Blackshear PJ |title=The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis. |journal=Arthritis Res. Ther. |volume=6 |issue= 6 |pages= 248-64 |year= 2005 |pmid= 15535838 |doi= 10.1186/ar1441 }}
}}
{{refend}}
{{protein-stub}}
end log.
