Nitrosourea
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| Nitrosourea | |
|---|---|
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| IUPAC name | nitrosourea |
| Identifiers | |
| CAS number | [13010-20-3] |
| PubChem | |
| SMILES | C(=O)(N)NN=O |
| Properties | |
| Molecular formula | CH3N3O2 |
| Molar mass | 89.0535 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Nitrosourea is both the name of a molecule, and a class of compounds that include a nitroso (R-NO) group and a urea.
Examples include:
- Carmustine
- Lomustine
- Semustine
- Ethylnitrosourea (ENU)
- Streptozotocin
Nitrosourea compounds are DNA alkylating agents and are often used in chemotherapy. They are lipophilic and thus can cross the blood-brain barrier, making them useful in the treatment of brain tumors such as glioblastoma multiforme.
[edit] Side Effects
Some nitrosoureas (e.g. Lomustine) have been associated with the development of interstitial lung disease[1]
[edit] External links
[edit] References
- ^ Tucci E, Verdiani P, Di Carlo S, Sforza V (1986). "Lomustine (CCNU)-induced pulmonary fibrosis.". Tumori 72 (1): 95-8. PMID 3952821.
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