Molindone

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Molindone
Systematic (IUPAC) name
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)- 1,5,6,7-tetrahydro-4H-indol-4-one
Identifiers
CAS number	7416-34-4
ATC code	N05AE02
PubChem	23897
Chemical data
Formula	C16H24N2O2
Mol. mass	276.374 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	1.5 hours
Excretion	Minor, renal and fecal
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status	℞-only(US)
Routes	Oral

Molindone is a therapeutic antipsychotic, used in the treatment of schizophrenia.^[1] It works by blocking the effects of dopamine in the brain, leading to diminished psychoses. It is rapidly absorbed when taken by mouth.

Molindone is sold under the product name Moban.

[edit] Adverse effects

Main article: Typical antipsychotic

The side effect profile of molindone is similar to that of other typical antipsychotics. Unlike most antipsychotics, however, molindone use is associated with weight loss.^[2][3]

[edit] See also

• Typical antipsychotic

[edit] References

1. ^ molindone (web). F.A. Davis Company. Retrieved on 2007-11-04.
2. ^ Bagnall A, Fenton M, Kleijnen J, Lewis R (2007). "Molindone for schizophrenia and severe mental illness". Cochrane Database Syst Rev (1): CD002083. doi:10.1002/14651858.CD002083.pub2. PMID 17253473. 
3. ^ Allison DB, Mentore JL, Heo M, et al (1999). "Antipsychotic-induced weight gain: a comprehensive research synthesis". Am J Psychiatry 156 (11): 1686–96. PMID 10553730.  Free full text

v • d • e Psycholeptics: antipsychotics (N05A) Phenothiazine typical antipsychotics Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine • Triflupromazine Other typical antipsychotics Indoles (Molindone) Butyrophenones (Azaperone, Benperidol, Bromperidol, Droperidol, Haloperidol, Trifluperidol) Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) other (Loxapine) Atypical antipsychotics Butyrophenones (Melperone) Indoles (Sertindole, Ziprasidone) Benzamides (Sulpiride, Remoxipride, Amisulpride) diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine)