Benperidol

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Benperidol
Systematic (IUPAC) name
1-[1-[4-(4-fluorophenyl)-4-oxo-butyl] -4-piperidyl]-3H-benzoimidazol-2-one
Identifiers
CAS number	983-42-6
ATC code	N05AD07
PubChem	16363
Chemical data
Formula	C22H24FN3O2
Mol. mass	381.443g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	℞-only(US)
Routes	Oral

Benperidol is a drug which is a highly potent butyrophenone derivative. It is in fact the most potent neuroleptic on the european market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol).^[1]. It is an antipsychotic, which can be used for the treatment of schizophrenia^[2], but it is primarily used to control deviant, antisocial hypersexual behaviour^[3], and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone.^[4]

Benperidol was discovered at Janssen Pharmaceutica in 1961.

[edit] References

1. ^ Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)
2. ^ Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.
3. ^ British National Formulary (49th), British Medical Association 2005 p 183
4. ^ Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.

v • d • e Psycholeptics: antipsychotics (N05A) Phenothiazine typical antipsychotics Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine • Triflupromazine Other typical antipsychotics Indoles (Molindone) Butyrophenones (Azaperone, Benperidol, Bromperidol, Droperidol, Haloperidol, Trifluperidol) Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) other (Loxapine) Atypical antipsychotics Butyrophenones (Melperone) Indoles (Sertindole, Ziprasidone) Benzamides (Sulpiride, Remoxipride, Amisulpride) diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine)