Butyrophenone

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Butyrophenone
IUPAC name	1-phenylbutan-1-one
Identifiers
CAS number
PubChem	10315
SMILES	CCCC(=O)C1=CC=CC=C1
Properties
Molecular formula	C10H12O
Molar mass	148.202
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Butyrophenone is a chemical compound (a ketone); some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.

Butyrophenones are a class of pharmaceutical drugs derived from butyrophenone.

Examples include:

• Haloperidol, the most widely-used drug in this class
• Droperidol, often used for neuroleptanalgesic anesthesia and sedation in intensive-care treatment
• Benperidol, the most potent commonly-used antipsychotic (~ 200 times more potent as chlorpromazine)
• Triperidol, a highly-potent antipsychotic (100 times more potent than chlorpromazine)
• Melperone, a weakly-potent antipsychotic, in Europe commonly used for treatment of insomnia, confusional states, psychomotor agitation, and delirium, in particular, in geriatric patients
• Lenperone
• Domperidone, a dopamine-antagonist antiemetic, derived further from butyrophenone (not being a butyrophenone itself).

The atypical antipsychotic risperidone, although not a butyrophenone, was developed with the structures of benperidol and lenperone as a basis.

v • d • e Psycholeptics: antipsychotics (N05A) Phenothiazine typical antipsychotics Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine • Triflupromazine Other typical antipsychotics Indoles (Molindone) Butyrophenones (Azaperone, Benperidol, Bromperidol, Droperidol, Haloperidol, Trifluperidol) Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) other (Loxapine) Atypical antipsychotics Butyrophenones (Melperone) Indoles (Sertindole, Ziprasidone) Benzamides (Sulpiride, Remoxipride, Amisulpride) diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine)