Histidine decarboxylase

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histidine decarboxylase
Identifiers
Symbol	HDC
Entrez	3067
HUGO	4855
OMIM	142704
RefSeq	NM_002112
UniProt	P19113
Other data
EC number	4.1.1.22
Locus	Chr. 15 q21-q22

Histidine decarboxylase (HDC) is the enzyme that catalyzes the reaction which produces histamine from histidine as follows:

C₆H₉N₃O₂ → C₅H₉N₃ + CO₂

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• MeSH Histidine+Decarboxylase

v • d • e Carbon-carbon lyases (EC 4.1) 4.1.1: Carboxy-lyases Pyruvate decarboxylase -Oxaloacetate decarboxylase - Acetoacetate decarboxylase - Malonyl-CoA decarboxylase - Glutamate decarboxylase - Ornithine decarboxylase - Lysine decarboxylase - Phosphoribosylaminoimidazole carboxylase - Histidine decarboxylase - Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase - Aromatic L-amino acid decarboxylase - Phosphoenolpyruvate carboxylase - Pyrophosphomevalonate decarboxylase - Uroporphyrinogen III decarboxylase - RuBisCO - Phosphoenolpyruvate carboxykinase - Adenosylmethionine decarboxylase 4.1.2: Aldehyde-lyases Aldolase A/Aldolase B - 2-hydroxyphytanoyl-CoA lyase - Threonine aldolase 4.1.3: Oxo-acid-lyases 3-hydroxy-3-methylglutaryl-CoA lyase

v • d • e Metabolism: amino acid metabolism - neurotransmitter enzymes histidine→histamine anabolism: Histidine decarboxylase catabolism: Histamine N-methyltransferase - Amine oxidase tyrosine→dopamine→epinephrine anabolism: Tyrosine hydroxylase - Aromatic L-amino acid decarboxylase - Dopamine beta hydroxylase - Phenylethanolamine N-methyltransferase catabolism: Catechol-O-methyl transferase - Monoamine oxidase glutamate→GABA anabolism: Glutamate decarboxylase catabolism: 4-aminobutyrate aminotransferase tryptophan→serotonin→melatonin Tryptophan hydroxylase - Aromatic L-amino acid decarboxylase - Acetylserotonin O-methyltransferase arginine→NO Nitric oxide synthase (NOS1, NOS2A, NOS3) see also intermediates