Phenylethanolamine N-methyltransferase

phenylethanolamine N-methyltransferase
Identifiers
Symbol	PNMT
Alt. Symbols	PENT
Entrez	5409
HUGO	9160
OMIM	171190
RefSeq	NM_002686
UniProt	P11086
Other data
EC number	2.1.1.28
Locus	Chr. 17 q21-q22

Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found in the adrenal medulla that converts Norepinephrine (Noradrenalin) to Epinephrine (Adrenalin).

PNMT is positively influenced by cortisol, which is produced in the adrenal cortex.

PNMT converts the last step in the synthesis of epinephrine

[edit] External links

v • d • e Transferase: one carbon transferases (EC 2.1)

2.1.1 - Methyltransferases	N-methyltransferase: Histamine N-methyltransferase - Phenylethanolamine N-methyltransferase - Tryptamine N-methyltransferase - Phosphatidylethanolamine N-methyltransferase O-methyltransferase: 5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase - Catechol-O-methyl transferase homocysteine methyltransferase: Betaine-homocysteine methyltransferase - Homocysteine methyltransferase - 5-Methyltetrahydrofolate-homocysteine methyltransferase Other: Phosphatidyl ethanolamine methyltransferase - DNMT3B - Histone methyltransferase - Thymidylate synthase - DNA methyltransferase

2.1.2 - Hydroxy methyl-, Formyl- and Related Transferases	Serine hydroxymethyltransferase - Phosphoribosylglycinamide formyltransferase - Inosine monophosphate synthase - Glutamate formimidoyltransferase - Aminomethyltransferase

2.1.3 - Carboxy- and Carbamoyl transferases	Ornithine transcarbamylase

2.1.4 - Amidino transferases	Arginine:glycine amidinotransferase

v • d • e Metabolism: amino acid metabolism - neurotransmitter enzymes

histidine→histamine	anabolism: Histidine decarboxylase catabolism: Histamine N-methyltransferase - Amine oxidase

tyrosine→dopamine→epinephrine	anabolism: Tyrosine hydroxylase - Aromatic L-amino acid decarboxylase - Dopamine beta hydroxylase - Phenylethanolamine N-methyltransferase catabolism: Catechol-O-methyl transferase - Monoamine oxidase

glutamate→GABA	anabolism: Glutamate decarboxylase catabolism: 4-aminobutyrate aminotransferase

tryptophan→serotonin→melatonin	Tryptophan hydroxylase - Aromatic L-amino acid decarboxylase - Acetylserotonin O-methyltransferase

arginine→NO	Nitric oxide synthase (NOS1, NOS2A, NOS3)

see also intermediates