2-hydroxyphytanoyl-CoA lyase

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2-hydroxyacyl-CoA lyase 1
Identifiers
Symbol	HACL1
Alt. Symbols	HPCL
Entrez	26061
HUGO	17856
OMIM	604300
RefSeq	NM_012260
UniProt	Q9UJ83
Other data
Locus	Chr. 3 p24.3

2-Hydroxyphytanoyl-CoA lyase is a peroxisomal enzyme involved in the catabolism of phytanoic acid. It requires thiamine diphosphate (ThDP) as cofactor.^[1]

It is classified under EC number 4.1.

[edit] References

1. ^ Foulon V, Antonenkov V, Croes K et al. (1999). "Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039–44. doi:10.1073/pnas.96.18.10039. PMID 10468558. 

[edit] External links

• MeSH 2-hydroxyphytanoyl-coenzyme+A+lyase

v • d • e Carbon-carbon lyases (EC 4.1) 4.1.1: Carboxy-lyases Pyruvate decarboxylase -Oxaloacetate decarboxylase - Acetoacetate decarboxylase - Malonyl-CoA decarboxylase - Glutamate decarboxylase - Ornithine decarboxylase - Lysine decarboxylase - Phosphoribosylaminoimidazole carboxylase - Histidine decarboxylase - Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase - Aromatic L-amino acid decarboxylase - Phosphoenolpyruvate carboxylase - Pyrophosphomevalonate decarboxylase - Uroporphyrinogen III decarboxylase - RuBisCO - Phosphoenolpyruvate carboxykinase - Adenosylmethionine decarboxylase 4.1.2: Aldehyde-lyases Aldolase A/Aldolase B - 2-hydroxyphytanoyl-CoA lyase - Threonine aldolase 4.1.3: Oxo-acid-lyases 3-hydroxy-3-methylglutaryl-CoA lyase