Talk:Gluten sensitivity

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[edit] Motifs (Extended information)

Below is an account of sequence motifs that are repeated in more than on gliadin isoform or more than one species. Assume that new entries of the motifs are available in the core nucleotide database.

[edit] Alpha gliadin "α-20" motifs

[1] (mat. 76-86)1, (88-98, mat +13)2, (89-99, mat +13)3, (95-105, mat +20)4, (96-106, mat +20)5, (101-111, mat. +20)6

[edit] Gamma gliadin "γ-30" motif

  • _AAK84773- (207-215) Triticum aestivum cheyenne (bread wheat)
  • _AAK84777- (236-244) Triticum aestivum cheyenne (bread wheat)
  • _AF120267- (246-254) Triticum aestivum spelta Oberkulmer
  • _AAK84778 -(249-257) Triticum aestivum cheyenne (bread wheat)
  • _AAK84777 -(253-261) Triticum aestivum cheyenne
  • _AAF42989 - (259-267) Triticum aestivum Yamhill
  • _AAK84774-(278-286) Triticum aestivum cheyenne
  • _AAK84779- (288-296) Triticum aestivum cheyenne (bread wheat)
  • many more in the Aegilops, Triticum, Thinopyrum genera.Pdeitiker 03:29, 30 June 2007 (UTC)

[edit] References

  1. ^ Vader W, Kooy Y, Van Veelen P, De Ru A, Harris D, Benckhuijsen W, Pena S, Mearin L, Drijfhout JW, and Koning F. (2002). "The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides.". Gastroenterology. 122 (7): 1729-1737. PMID 12055577. 

[edit] Audience

Hey folken. I'm concerned that this page is too dense in its current state. I don't suggest removing any information, but perhaps some jargon could be better explained. I'm a molecular biology graduate student and I'm still having trouble getting through it. I realize that immunology is very complicated, and that it may be impossible to avoid jargon completely; but I'd also recommend that it be reduced. See also: Tone, particularly the parts on jargon and context. --aciel (talk) 00:00, 8 January 2008 (UTC)


I agree the page is dense it took me a few reads (and a bit of background reading) to understand it but please do not make the mistake of oversimplification. This is a complex issue and I have found this page and its associated links enormously helpful in understanding what is really at the core of this affliction I have. Thanks to the Authors. 203.58.120.11 (talk) 23:09, 19 February 2008 (UTC)NBelford

The jargon tag was removed without an edit comment, and without discussing here. Kindly do not remove this tag until consensus is reached HERE that this issue has been resolved. Thank you. Socrates2008 (Talk) 23:05, 23 February 2008 (UTC)

Wow! Great article. There is a lot of new information coming out in this field and this article does an incredible job of collecting it. This was a lot of work. The other commenters thoughts reflect the technical nature of this article. The article could use an introductory article (certainly more than a paragraph) to ease readers with less of a technical background into the article. Kd4ttc (talk) 04:12, 26 February 2008 (UTC)

[edit] Gluten sensitivity and Multiple Sclerosis

This article is so unreadable. It moves from kind of easy to read to lots of technical nomenclature. Also, what's with the blaming gluten on every disease. For example, gluten sensitivity has nothing to do with MS, yet the article makes it read like it's causal. At best, there's some sensitivity for patients with MS, but that's hardly definitive. OrangeMarlin Talk• Contributions 20:02, 2 March 2008 (UTC)

The inclusion of the article on multiple schlerosis follows a strand within the literature that associates the incidence of anti-gliadin antibodies with other neurological diseases. Personally, I question whether there is significance after the association with GSE has been elucidated, but that is my opinion. The purpose of this page is to _differentiate_ three forms of gluten or wheat sensitivity discussed either in the literature or by third party genetic typing groups. As these groups are frequently assigning risk of disease (GSE, IGS, or allergy) based on genetic typing and AGA. It is not to validate these claims, simply to parse the claims into groupings so that people do not confuse MS w/AGA as being celiac disease.
Note: One of the factors that is associated with MS, particularly stress to the nervous system. Gluten sensitivity in any of its forms can cause the types of stress that can cause crisis for MS patients. As for the readability issues, I have been quite busy for the last few months. I am getting back to editing the article to create an encyclopedic format where-ever possible. Currently working on the immunochemistry section. Wikilinks will be provided whereever possible, so that the reader can read on the technical words used to describe each type of sensitivity. Pdeitiker (talk) 16:27, 7 June 2008 (UTC)

"OBJECTIVE: We wanted to measure immunoglobulin A (IgA) antibodies to some common food antigens in MS and also IgG against gliadin and gluten. METHODS: The IgA antibodies were measured in serum against gluten, gliadin, lactoglobulin, lactalbumin, casein and ovalbumin in patients with MS and controls using ELISA technique. IgG was likewise measured for gluten and gliadin. RESULTS: Highly significant increases compared with controls were found for IgA and IgG antibodies against gliadin and gluten. IgA antibodies against casein were significantly increased. Anti-endomycium and anti-transglutaminase antibodies were negative."[1]

"Two atypical patients with a multiple sclerosis (MS)-like illness and evidence of occult celiac disease (CD) were managed by the authors. This prompted screening of a further 49 unselected MS cases for serologic evidence of CD. IgA anti-endomysial antibody was found in one case (2%). IgG anti-gliadin antibody was found in 12% of patients and 13% of blood donors. Anti-gliadin antibody (especially IgG isotype) can be a nonspecific finding."[2]

I interpret this finding like many others that recently appear in the literature. There are factors in the western diet that allow the penetration of food peptides into systemic circulation. Omega-gliadin is one which is involved in anaphlaxis and urticaria. It can also be induced by Aspirin or NSAIDS, or other factors such as MSG, benzoate, or tartazine. The wiki page on idiopathic disease identifies that these findings could be due to GSE or Allergy, but there is also the possibility that gliadin directly interfers with neurologcal function. There is simply not enough data.Pdeitiker (talk) 03:08, 9 June 2008 (UTC)

"Recent investigations have documented that aspirin consumption, in place of exercise, also induces allergic symptoms. CASE SUMMARY: A 63-year-old man began low dose aspirin therapy on September 2005. Since January 2006, he had repeated episodes of generalized urticaria and lost consciousness while he was exercising after eating wheat. He was strongly positive for omega-5 gliadin in a cap-system fluorescent enzyme immunoassay. Therefore, a diagnosis of wheat-dependent exercise-induced anaphylaxis was made. DISCUSSION: Patients with aspirin-provoked FDEIA have been reported previously as taking ordinary doses of aspirin for reducing pain, inflammation and fever. However, in our patient, low dose aspirin therapy for reducing cardiovascular risk possibility induced FDEIA."[3],

There are other case findings for these effects of aspirin are published, aspirin appears to be a gluten sensitizer.
  1. ^ Agardh D (November 2007). "Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease". Clin. Gastroenterol. Hepatol. 5 (11): 1276–81. doi:10.1016/j.cgh.2007.05.024. PMID 17683995. 
  2. ^ Pengiran Tengah CD, Lock RJ, Unsworth DJ, Wills AJ (June 2004). "Multiple sclerosis and occult gluten sensitivity". Neurology 62 (12): 2326–7. PMID 15210909. 
  3. ^ Fujii H, Kambe N, Fujisawa A, Kohno K, Morita E, Miyachi Y (March 2008). "Food-dependent exercise-induced anaphylaxis induced by low dose aspirin therapy". Allergol Int 57 (1): 97–8. doi:10.2332/allergolint.C-07-53. PMID 18089939. 

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