Etafedrine

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Etafedrine
Systematic (IUPAC) name
2-(ethyl-methylamino)-1-phenylpropan-1-ol
Identifiers
CAS number 7681-79-0
7681-79-0 (hydrochloride)
ATC code  ?
PubChem 10734
Chemical data
Formula C12H19NO 
Mol. mass 193.285 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has the brand name Nethaprin. It is commercially available as both the free base, and as the hydrochloride.

It is no longer marketed by Sanofi-Aventis.

[edit] Synthesis

Ethylephedrine may be synthesized by alkylating ephedrine with ethyl iodide. The hydrochloride may be prepared by passing hydrogen chloride through a solution of ethylephedrine in diethyl ether.[1]

[edit] References

  1. ^ Takeo Ueda,Shigeshi Toyoshima,Kiyoshi Takahashi and Masako Muraoka (1955). "Studies on Syntheses and Pharmacological Effects of N-Alkylephedrines and their Ammonium Salt Derivatives" (Free full text). Pharm. Bull. (Japan) 3 (6): 465–468. 
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