Endonuclease/Exonuclease/phosphatase family

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Endonuclease/Exonuclease/phosphatase family
Identifiers
Symbol	Exo_endo_phos
Pfam	PF03372
InterPro	IPR005135
SCOP	1ako
OPM family	148
OPM protein	1zwx
Available PDB structures: 1i9yA:560-846 1i9zA:560-846 1si6X:29-298 1y21A:29-298 1ntfA:29-298 1zwxA:45-332 1ako :1-266 1de9A:62-316 1de8A:62-316 1cqgB:62-70 1dewA:62-316 1cqhB:62-70 1e9nA:62-316 1hd7A:62-316 1bix :62-316 1lyrA:62-316 1xzsA:62-316 1xzrA:62-316 1xztA:62-316 1wduB:56-180 1sr4B:27-281 2a41B:23-281 1dnkA:23-281 2a40B:23-281 2dnjA:23-281 2a3zB:23-281 3dni :23-281 1atnD:23-281 2a42B:23-281

Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling ^[1].

Contents 1 Examples 2 Subfamilies 3 Human proteins containing this domain 4 Notes 5 References

[edit] Examples

• AP endonuclease proteins EC 4.2.99.18,
• DNase I proteins EC 3.1.21.1,
• Synaptojanin, an inositol-1,4,5-trisphosphate phosphatase EC 3.1.3.56
• Sphingomyelinase EC 3.1.4.12 and Nocturnin UniProt O35710.

[edit] Subfamilies

• Inositol polyphosphate related phosphatase IPR000300

[edit] Human proteins containing this domain

2'-PDE; 2-PDE; ANGEL1; ANGEL2; APEX1; APEX2; CCRN4L; CNOT6; CNOT6L; DNASE1; DNASE1L1; DNASE1L2; DNASE1L3; INPP5A; INPP5B; INPP5D; INPP5E; INPPL1; KIAA1706; OCRL; PIB5PA; SKIP; SMPD2; SMPD3; SYNJ1; SYNJ2; TTRAP;

[edit] Notes

[edit] References

• [1]. Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. Dlakic M; Trends Biochem Sci 2000;25:272-273. PubMed
• [2]. Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA; Nature 1995;374:381-386. PubMed
• [3]. DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. Lahm A, Suck D; J Mol Biol 1991;222:645-667. PubMed