INPP5A

From Wikipedia, the free encyclopedia

Inositol polyphosphate-5-phosphatase, 40kDa

Identifiers

INPP5A; 5PTASE; DKFZp434A1721; MGC116947; MGC116949

External IDs

OMIM: 600106 MGI: 2686961 HomoloGene: 4045

Gene ontology
Molecular Function:	• inositol or phosphatidylinositol phosphatase activity • inositol-polyphosphate 5-phosphatase activity • hydrolase activity
Cellular Component:	• membrane
Biological Process:	• cell communication

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

XM_001133189 (mRNA)
XP_001133189 (protein)

NM_183144 (mRNA)
NP_898967 (protein)

Location

Chr 10: 134.2 - 134.45 Mb

Chr 7: 139.24 - 139.43 Mb

Pubmed search

[1]

[2]

Inositol polyphosphate-5-phosphatase, 40kDa, also known as INPP5A, is a human gene.^[1]

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.^[1]

[edit] References

^ ^a ^b Entrez Gene: INPP5A inositol polyphosphate-5-phosphatase, 40kDa.

[edit] Further reading

Laxminarayan KM, Chan BK, Tetaz T, et al. (1994). "Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase.". J. Biol. Chem. 269 (25): 17305–10. PMID 8006039.
De Smedt F, Verjans B, Mailleux P, Erneux C (1994). "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells.". FEBS Lett. 347 (1): 69–72. PMID 8013665.
Mitchell CA, Speed CJ, Nicholl J, Sutherland GR (1996). "Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization.". Genomics 31 (1): 139–40. doi:10.1006/geno.1996.0023. PMID 8808294.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Auethavekiat V, Abrams CS, Majerus PW (1997). "Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I.". J. Biol. Chem. 272 (3): 1786–90. PMID 8999861.
Campbell JK, Gurung R, Romero S, et al. (1998). "Activation of the 43 kDa inositol polyphosphate 5-phosphatase by 14-3-3zeta.". Biochemistry 36 (49): 15363–70. doi:10.1021/bi9708085. PMID 9398266.
Lee SH, Davison JA, Vidal SM, Belouchi A (2001). "Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors.". Mamm. Genome 12 (2): 157–62. PMID 11210186.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hartmann TB, Thiel D, Dummer R, et al. (2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.". Br. J. Dermatol. 150 (2): 252–8. PMID 14996095.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.