SMPD2

From Wikipedia, the free encyclopedia

Sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)

Identifiers

SMPD2; NSMASE

External IDs

OMIM: 603498 MGI: 1278330 HomoloGene: 31129

Gene ontology
Molecular Function:	• magnesium ion binding • sphingomyelin phosphodiesterase activity • hydrolase activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• sphingomyelin metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003080 (mRNA)
NP_003071 (protein)

NM_009213 (mRNA)
NP_033239 (protein)

Location

Chr 6: 109.87 - 109.87 Mb

Chr 10: 41.18 - 41.18 Mb

Pubmed search

[1]

[2]

Sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase), also known as SMPD2, is a human gene.^[1]

[edit] References

^ Entrez Gene: SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase).

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Tomiuk S, Hofmann K, Nix M, et al. (1998). "Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3638–43. PMID 9520418.
Sawai H, Domae N, Nagan N, Hannun YA (2000). "Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C.". J. Biol. Chem. 274 (53): 38131–9. PMID 10608884.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Marchesini N, Osta W, Bielawski J, et al. (2004). "Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells.". J. Biol. Chem. 279 (24): 25101–11. doi:10.1074/jbc.M313662200. PMID 15051724.
Jensen JM, Fölster-Holst R, Baranowsky A, et al. (2004). "Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis.". J. Invest. Dermatol. 122 (6): 1423–31. doi:10.1111/j.0022-202X.2004.22621.x. PMID 15175033.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Jana A, Pahan K (2005). "Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase.". J. Neurosci. 24 (43): 9531–40. doi:10.1523/JNEUROSCI.3085-04.2004. PMID 15509740.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Kim HT, Lee JY, Han BG, et al. (2007). "Association analysis of sphingomyelinase 2 polymorphisms for the extrinsic type of atopic dermatitis in Koreans.". J. Dermatol. Sci. 46 (2): 143–6. doi:10.1016/j.jdermsci.2006.12.001. PMID 17212982.
Tani M, Hannun YA (2007). "Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization.". J. Biol. Chem. 282 (13): 10047–56. doi:10.1074/jbc.M611249200. PMID 17272284.