Dopac
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| Dopac | |
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| IUPAC name | 2-(3,4-dihydroxyphenyl)acetic acid |
| Identifiers | |
| CAS number | [102-32-9] |
| PubChem | |
| MeSH | |
| SMILES | C1=CC(=C(C=C1CC(=O)O)O)O |
| Properties | |
| Molecular formula | C8H8O4 |
| Molar mass | 168.14672 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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DOPAC (dihydroxyphenylacetic acid) is a metabolite of dopamine.[1]
[edit] Pathway
The dopaminergic pathway consists of the following:
----> via MAO -> '''DOPAC''' -> via COMT
/ \
'''Dopamine (DA)''' . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ---> '''homovanillic acid (HVA)'''
\ /
----> via COMT -> '''3-MT''' -> via MAO
[edit] Clinical significance
One of the three direct products from the alteration of dopamine (DOPAC, 3-MT (3-methoxytyramine) and noradrenaline) DOPAC is an important metabolite when studying the behaviour of the dopaminergic system for multiple reasons; 3-MT is generally more difficult to assay alongside dopamine and by assessing all three metabolites (DOPAC, HVA and 3-MT) abnormalities in either COMT (catechol-O-methyl transferase) or MAO (monoamine oxidase) can be indirectly identified. This has large ramifications as COMT abnormalities are suspected in various neuropsychiatric diseases including schizophrenia.
[edit] References
- ^ Sistrunk SC, Ross MK, Filipov NM (May 2007). "Direct effects of manganese compounds on dopamine and its metabolite Dopac: an in vitro study". Environ. Toxicol. Pharmacol. 23 (3): 286–296. doi:. PMID 18449324.
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