3-Methoxy-4-hydroxyphenylglycol

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3-Methoxy-4-hydroxyphenylglycol
IUPAC name 1-(4-Hydroxy-3-methoxyphenyl)ethane-1,2-diol
Other names MHPG
Identifiers
CAS number [67423-45-4]
PubChem 10805
MeSH Methoxyhydroxyphenylglycol
SMILES COC1=C(C=CC(=C1)C(CO)O)O
Properties
Molecular formula C9H12O4
Molar mass 184.18918
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

3-Methoxy-4-hydroxyphenylglycol (MHPG) is a metabolite of norepinephrine degradation. In the brain, it is the principal norepinephrine metabolite. It is released into the blood and cerebrospinal fluid,[1] and a blood sample of it may therefore be an indication of recent sympathetic nervous system activity.

[edit] References

  1. ^ Increase in cerebrospinal fluid and plasma levels of 3-methoxy-4- hydroxyphenylglycol in acute stroke T Kanda, K Azuma, F Sakai and Y Tazaki. Department of Internal Medicine, School of Medicine, Kitasato University, Sagamihara, Japan.
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Neurotransmitter metabolic intermediates
tyrosine→dopamine→epinephrine
Catecholamine metabolites
epinephrine/norepinephrine: 3,4-Dihydroxymandelic acid - Metanephrine/Normetanephrine - Vanillyl mandelic acid - 3-Methoxy-4-hydroxyphenylglycol
dopamine: Dopac - 3-Methoxytyramine - Homovanillic acid
tryptophan→serotonin
serotonin→melatonin
see also enzymes