User:CopperKettle
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I live in Ekaterinburg, Russia. My interests include psychiatry and neuroscience.
I love the music of Bob Dylan, Boris Grebenshikov, Frank Zappa, Chumbawamba, Umka and Beethoven's string quartets. I enjoy skiing and jogging, playing tennis.
My favourite authors are John Updike, Viktor Pelevin, Fyodor Dostoyevsky, Kurt Vonnegut.
I participate in the Folding@home project. My last.fm account is here.
My Wikimedia page. My statistics.
Contents |
[edit] Pages I've started
- DAB1
- Cajal-Retzius cell
- Reeler
- VLDL receptor
- Yotari
- Pioneer neuron
- Low density lipoprotein receptor gene family
- Radial glia
- Martinotti cell
- Homovanillic acid
- Victor Pavlovich Protopopov
- Subventricular zone
- Subplate zone (brain)
- Umka and the armoured car
- Chandelier neuron - did a little stub, will try to expand.
- Vladimir Alekseyevich Betz - done.
- NPAS3 - resides in HAR21 region, linked to schizophrenia; knockout mice show decrease in reelin expression. Did a stub.
- ApoER2 - stub.
- Shaking rat Kawasaki
- Cystatin C - stub.
- Subgranular zone - stub.
- Alpha-enolase
- Neuregulin 1
- GAB2 - stub based on a BBC news report.
- Leukoencephalopathy with vanishing white matter - stub based on this comment.
- Douglas Scott Falconer - tiny stub.
- D-amino acid oxidase activator
- RGS4 - stub.
- DISC1 - stub.
- Chakragati mouse - a hasty stub.
- NARSAD - stub.
- GPR35 receptor; stub
- S100B - brain-specific protein; potential neurophathology marker. PMID 17348038.
- myeloid/lymphoid or mixed-lineage leukemia 1, Mixed Lineage Leukemia 1 or MLL1, Mll1; may be involved in GAD1 downreg. in schiz. (OMIM?) gene db at pubmed
- biogenesis of lysosome-related organelles complex 1, or BLOC-1, which includes dysbindin.
- Kalirin (OMIM 604605), including its isoform Kalirin-7; based on a text from schizophreniaforum.org.
- Norman-Roberts syndrome, a rare lissencephaly syndrome caused by a mutation in the reelin gene.
- VLDLR-associated cerebellar hypoplasia
- Huntingtin-associated protein 1
- VGF protein - increased expression in schizophrenia (CSF samples). (OMIM)
- CABP1 or Caldendrin, a novel Calcium-binding protein.
- Yuri Nuller, Yuri Lvovich Nuller, Russian psychiatrist.
- GHB receptor - apparently bound by sulpiride and amisulpride.
- Frank Ayd, american psychiatrist
[edit] Articles To Start
- Double bouquet cell (= fusiform cell?)
- DNA methyltransferase-1 - overexpressed in psychosis, downregulates GAD67 and Reelin in GABAergic interneurons of schizophrenia and bipolar patients.
- GABAergic interneuron - I'm not sure but there seems to be an extensive array of GABAergic interneuron subtypes - 14 subtypes according to Gupta et al, 2000. PMID 10634775
- GABA membrane transporter-1, or GAT-1 - seems to be decreased in schizophrenia.(Also: PMID 15365220) Seems also to be increased by antipsychotics in mice: PMID 15467974. There are clinical studies of GAT-1 inhibitor tiagabine as an add-on in schizophrenia: 1 2.
- or maybe just GABA transporters for a start.
- Axo-axonic cell (?)
- "Reelin and GAD67 are not the only genes whose expression is down-regulated in GABAergic neurons of SZ and BP+ patients. For example, the expression of GABA transporter (GAT1) (30), parvalbumin (25) or N-methyl-d-aspartate receptor subunits (15) is also down-regulated in GABAergic neurons of SZ and BP+ patients." [1] Got to be investigated. GAT1 and parvalbumin decrease seems to occur in disctinct GABAergic interneuron populations from the reelin-containing cells. So it seems.
- Meynert cell - a specialized pyramidal neuron of the visual cortex.
- Line bisection task (?) - used to detect visuospatial neglects.
- BHLH-PAS superfamily of transcription factors - maybe.
- Wide arbor cell (?)
- Postsynaptic density 95 or PSD95, or, more rightly, DISCS LARGE, DROSOPHILA, HOMOLOG OF, 4; DLG4
- NMDA subunit NR2A, NMDA subunit NR2B - OMIM links: 1, 2.
- Ganglionic eminence
- Ramon Castroviejo - corneal transplantation pioneer
- Abnormal involuntary movement scale, AIMS - measuring tardive dyskinesia.
- Continuous Performance Test, Identical Pairs Version, or CPT-IP
- PirB - in cahoots with MHC class I; affects neuronal circuitry. [2]; [3].
- Antisaccade task
- P50 sensory gating test (or P50 (evoked potential)?) - lack of ihnibition in schizophrenia.
- Binocular depth inversion (?)
- Salvianolic Acid (?)
- Miraxion - artificial eicosapentaenoic acid.
- Artificial cornea (keratoprosthesis)
- Contingent Negative Variation (??)
- Maternal deprivation (??)
- visual backward masking, motion integration (PMID 17487285)
- Go-NoGo task disruption in ADHD, schizophrenia.
- KIBRA protein associated with memory performance. (OMIM)
- Kinectin, a microtubule-associated protein.
- Oculomotor delayed response task, ODR
- Etazolate, PDE inhibitor.
- trisynaptic pathway in hippocampus.
- preparing to overcome prepotency task, or POP task which is based on Simon spatial incompatibility effect
- Social defeat or social defeat stress - may be a risk factor in schizophrenia.
- Uchida-Kraepelin test(?)
- septohippocampal pathway
- RGS proteins (?)
- granular retrosplenial cortex (?)
- Sprague effect - "an unusual phenomenon known as the Sprague effect. Complete removal of the visual cortex on one side of the brain renders animals unable to see anything in the half of the visual field opposite the surgical site. Yet a tiny cut to the midbrain restores the animal's ability to detect and approach moving entities, even though it still can't distinguish one object from another."
- Herpes Encephalitis
- Maternal immune activation - behaviour changes in rodents similar to schizophrenia, autism; probably via IL-6 cytokine.
- Binding immunoglobulin protein (immunoglobulin heavy chain binding protein ), BiP, a.k.a. Grp78
- PSE-Catego (?) psychiatric diagnostic system
- Glutamate carboxypeptidase III, GCPIII
- Glucose Tolerance Factor
- fluorodopa 18F, FDOPA
- Steroid dementia, Steroid dementia syndrome
- kynurenine metabolic pathway
- 5-hydroxyindole acetic acid, or simply 5-hydroxyindole, a metabolite of tryptophan.
- Brachydactyly mental retardation syndrome, OMIM 600430
- methylazoxymethanol acetate model of schizophrenia, MAM model of schizophrenia
- methylazoxymethanol acetate
- FABP 7, a member of Fatty acid-binding protein family, linked to disrupted PPI in schizophrenia.
- Quinolinic acid
- dystrophin-associated protein complex, DPC
- Biogenesis of lysosome-related organelles complex 2, BLOC-2
- Biogenesis of lysosome-related organelles complex 3, BLOC-3
- Sandy (mouse) or SDY, a dysbindin knockout mouse.
- X-linked chronic granulomatous disease (caused by a mutation in NADPH oxidase subunit genes; OMIM link)
- Optogenetics (?)
- Kendler's Structured Interview for Schizotypy
- oriens-lacunosum moleculare (O-LM) interneurons
- Corticogenesis
- periventricular nodular heterotopia: In a normal brain, much of the gray matter (consisting mostly of nerve cells) appears on the brain’s surface, while white matter (consisting mostly of nerve fibers, or “wiring,” connecting areas of gray matter) runs deeper in the brain. In PNH, nodules of gray matter sit deep in the brain’s core, in the white matter; they failed to migrate out to the surface as the brain was developing.
- Forced normalization (?) - psychotic symptoms associated with seizure control in epilepsy (described here).
- Unertan syndrome - see Ulas family
- Default network (brain)
- Ivy cells of the hippocampus
- Use-dependent plasticity
- Animal models of schizophrenia
- The cytomatrix active zone (CAZ) is a specialized cellular structure regulating release of vesicles
- nail fold (nailfold plexus visibility, NPV, as a sign of schizophrenia assoc. w\neg. symp.)
[edit] Articles to expand and improve
- PAFAH1B1, or LIS1, implicated in lissencephaly and in reelin pathway.
- Dysbindin
- Endophenotype - definitely needs improvement as of 2 dec 2007.
[edit] Articles to improve:
- Glutamate hypothesis of schizophrenia - fix the errors, add relevant links.
- Prepulse inhibition - expanded, image and some refs added; more work needed.
[edit] Articles I've contributed to
- Reelin - very important protein, regulating the processes of neuronal migration and positioning. Involved in the pathogenesis of schizophrenia and bipolar disorder.
- Glutamate decarboxylase - GAD67 is linked to schizophrenia too. Both GAD67 and reelin are regulated by same (epigenetic?) mechanism, both are scarce in schizophrenia, probably due to increase of DNMT1 expression in GABAergic interneurons (or due to TrkB dysfunction, or maybe these are in the different cell subtypes).
- Apolipoprotein E
- Trimethylglycine, or Betaine
- Lissencephaly
[edit] Useful pages, FAQs
- Wikipedia:Image use policy
- Portal:Neuroscience
- Portal:Mind and Brain
- WikiProject Russia
- Portal:Artificial_intelligence
- HTML-to-Wiki converter
- WikiEd
- Wikipedia:Citing_sources
- Template:Cite journal
- Template:Doi
[edit] Tools for protein infobox
First get HGNCID here, next populate using this tool here.
[edit] commons:User:CopperKettle
I assert to be the same user as commons:User:CopperKettle --CopperKettle 14:03, 22 February 2007 (UTC)

