Leukoencephalopathy with vanishing white matter
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| Leukoencephalopathy with vanishing white matter Classification and external resources |
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| OMIM | 603896 |
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Leukoencephalopathy with vanishing white matter (VWM disease) is an autosomal recessive neurological disease. The cause of the disease are mutations in any of the 5 genes encoding subunits of the translation initiation factor EIF2B: EIF2B1, EIF2B2, EIF2B3, EIF2B4, or EIF2B5.
Adult-onset VWM disease can present with psychosis and may be hard to differentiate from schizophrenia.[1]
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[edit] Synonyms
- childhood ataxia with central nervous system hypomyelinization; CACH
- vanishing white matter leukodystrophy
- cree leukoencephalopathy; CLE
- vanishing white matter leukodystrophy with ovarian failure, included
- ovarioleukodystrophy, included
[edit] See also
- CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)
- Progressive multifocal leukoencephalopathy
- Metachromatic leukodystrophy
[edit] References
- ^ Denier C, Orgibet A, Roffi F, Jouvent E, Buhl C, Niel F, Boespflug-Tanguy O, Said G, Ducreux D (2007). "Adult-onset vanishing white matter leukoencephalopathy presenting as psychosis". Neurology 68 (18): 1538–9. doi:. PMID 17470759.
[edit] External links
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