Co-tenidone

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Co-tenidone
Combination of
Atenolol	Beta blocker
Chlortalidone	Thiazide diuretic
Identifiers
CAS number	?
ATC code	?
PubChem	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM(UK)
Routes	Oral

Co-tenidone (BAN) is a non-proprietary name used to denote a combination of atenolol and chlortalidone. Co-tenidone is used in the treatment of hypertension. The use of β-blockers in hypertension was downgraded in June 2006 in the United Kingdom to fourth-line as they perform less well than other drugs, and that atenolol, the most frequently used β-blocker, at usual doses carries an unacceptable risk of provoking type 2 diabetes.^[1]

[edit] Formulation

Two strengths of co-amilozide is currently available in the UK:

• 50 mg atenolol and 12.5 mg chlortalidone , BAN of Co-tenidone 50/12.5
• 100 mg atenolol and 25 mg chlortalidone , BAN of Co-tenidone 100/25

[edit] References

• British National Formulary 54 September 2007

[edit] Footnotes

1. ^ Sheetal Ladva (28/06/2006). NICE and BHS launch updated hypertension guideline. National Institute for Health and Clinical Excellence.

v • d • e Antihypertensives (C02) and diuretics (C03) Sympatholytic agents (including alpha) centrally acting/antiadrenergics: Clonidine • Guanfacine • Methyldopa • Moxonidine • Rilmenidine • adrenergic uptake inhibitor (Rescinnamine, Reserpine) ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) peripherally acting/antiadrenergics (Prazosin, Guanethidine, Indoramin, Doxazosin) Vasodilators Diazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine Other antihypertensives serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan) Low ceiling diuretics Thiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine High ceiling diuretics Loop diuretic (Bumetanide, Furosemide, Torasemide) Potassium-sparing diuretics ESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)