Potassium canrenoate


Potassium canrenoate
Systematic (IUPAC) name
potassium 3-[(8R,9S,10R,13S,14S,17R)- 17-hydroxy-10,13-dimethyl-3-oxo-2,8,9, 11,12,14,15,16-octahydro-1H-cyclopenta[a] phenanthren-17-yl]propanoate
Identifiers
CAS number	?
ATC code	C03DA02
PubChem	656614
Chemical data
Formula	C₂₂H₂₉KO₄
Mol. mass	369.516 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	?
Excretion	Renal and fecal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Intravenous

Potassium canrenoate (INN) or canrenoate potassium (USAN), the potassium salt of canrenoic acid, is an aldosterone antagonist.

Like spironolactone, it is a prodrug, which is metabolized to canrenone in the body.

[edit] See also

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v • d • e Antihypertensives (C02) and diuretics (C03)

Sympatholytic agents (including alpha)	centrally acting/antiadrenergics: Clonidine • Guanfacine • Methyldopa • Moxonidine • Rilmenidine • adrenergic uptake inhibitor (Rescinnamine, Reserpine) ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) peripherally acting/antiadrenergics (Prazosin, Guanethidine, Indoramin, Doxazosin)

Vasodilators	Diazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine

Other antihypertensives	serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan)

Low ceiling diuretics	Thiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine

High ceiling diuretics	Loop diuretic (Bumetanide, Furosemide, Torasemide)

Potassium-sparing diuretics	ESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)