Quinethazone


Quinethazone
Systematic (IUPAC) name
7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline- 6-sulfonamide
Identifiers
CAS number	73-49-4
ATC code	C03BA02
PubChem	6307
Chemical data
Formula	C₁₀H₁₂Cl N₃O₃S
Mol. mass	289.739 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral

Quinethazone (INN, brand name Hydromox) is a thiazide diuretic used to treat hypertension. Common side effects include dizziness, dry mouth, nausea, and low potassium levels.

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v • d • e Antihypertensives (C02) and diuretics (C03)

Sympatholytic agents (including alpha)	centrally acting/antiadrenergics: Clonidine • Guanfacine • Methyldopa • Moxonidine • Rilmenidine • adrenergic uptake inhibitor (Rescinnamine, Reserpine) ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) peripherally acting/antiadrenergics (Prazosin, Guanethidine, Indoramin, Doxazosin)

Vasodilators	Diazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine

Other antihypertensives	serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan)

Low ceiling diuretics	Thiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine

High ceiling diuretics	Loop diuretic (Bumetanide, Furosemide, Torasemide)

Potassium-sparing diuretics	ESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)