Bendroflumethiazide

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Bendroflumethiazide
Systematic (IUPAC) name
3-benzyl-5,5-dioxo-9- (trifluoromethyl)-5λ6- thia-2,4-diazabicyclo[4.4.0]deca-7, 9,11-triene-8-sulfonamide
Identifiers
CAS number	73-48-3
ATC code	C03AA01
PubChem	2315
DrugBank	APRD00666
Chemical data
Formula	C15H14F3N3O4S2
Mol. mass	421.417 g/mol
Pharmacokinetic data
Bioavailability	100%
Protein binding	96%
Metabolism	extensive
Half life	3-4 hours[1]
Excretion	?
Therapeutic considerations
Pregnancy cat.	Risk neonatal thrombocytopenia in 3rd trimester[2]
Legal status	POM(UK)
Routes	oral

Bendroflumethiazide INN (formerly BAN bendrofluazide), is a thiazide diuretic, used to treat hypertension.

[edit] Footnotes

1. ^ in Ed. Sean C. Sweetman: Martindale: The complete drug reference, 33, Pharmaceutical Press. 
2. ^ BNF 45 March 2003

[edit] External links

v • d • e Antihypertensives (C02) and diuretics (C03) Sympatholytic agents (including alpha) centrally acting/antiadrenergics: Clonidine • Guanfacine • Methyldopa • Moxonidine • Rilmenidine • adrenergic uptake inhibitor (Rescinnamine, Reserpine) ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) peripherally acting/antiadrenergics (Prazosin, Guanethidine, Indoramin, Doxazosin) Vasodilators Diazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine Other antihypertensives serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan) Low ceiling diuretics Thiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine High ceiling diuretics Loop diuretic (Bumetanide, Furosemide, Torasemide) Potassium-sparing diuretics ESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)