Cefazolin
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Cefazolin
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| Systematic (IUPAC) name | |
| 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]- 8-oxo-7-([2-(tetrazol-1-yl)acetyl]amino)- 5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylate |
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| Identifiers | |
| CAS number | |
| ATC code | J01 |
| PubChem | |
| Chemical data | |
| Formula | C14H13N8O4S3 |
| Mol. mass | 454.51 g/mol |
| Pharmacokinetic data | |
| Bioavailability | NA |
| Metabolism | ? |
| Half life | 1.8 hours (given IV) 2 hours (given IM) |
| Excretion | Renal, unchanged |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status |
℞ Prescription only |
| Routes | Intravenous, intramuscular |
Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic.
The drug is usually administrated either by intramuscular injection (injection into a large muscle) or intravenous infusion (intravenous fluid into a vein).
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[edit] Indications
Cefazolin is mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. These organisms are common on normal human skin. Resistance to cefazolin is seen in several species of bacteria.
[edit] Side effects
Side effects from cefazolin are not common. Possible side effects include:
- diarrhea
- stomach pain
- upset stomach
- vomiting
[edit] Brands
Cefazolin is marketed under the following brand names: Ancef, Cefacidal, Cefamezin, Cefrina, Elzogram, Faxilen, Gramaxin, Kefazol, Kefol, Kefzol, Kefzolan, Kezolin, Novaporin, and Zolicef.
[edit] External links
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