Brompheniramine
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Brompheniramine
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| Systematic (IUPAC) name | |
| 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine | |
| Identifiers | |
| CAS number | |
| ATC code | R06 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C16H19BrN2 |
| Mol. mass | 319.24 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Hepatic |
| Half life | ? |
| Excretion | Urine |
| Therapeutic considerations | |
| Pregnancy cat. |
C (USA) |
| Legal status |
Unscheduled, OTC |
| Routes | Oral |
Brompheniramine (also known as Bromfed, Dimetapp, Bromfenex, and Dimetane) is an antihistamine drug of the propylamine (alkylamine) class. It is commonly available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. It is a first-generation antihistamine.
Brompheniramine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin. Based on this knowledge, Arvid Carlsson and his colleagues, working at the Swedish company Astra AB, were able to derive the first marketed selective serotonin reuptake inhibitor, zimelidine, from brompheniramine.[1]
Like other agents of this type, brompheniramine also has analgesic-sparing (potentiating) effects on opioid analgesics, commonly reducing codeine, dihydrocodeine, and hydrocodone requirements by 10 to 35 per cent.
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[edit] Pharmacology
Brompheniramine works by acting as an antagonist of histamine H1 receptors. It also functions as a moderately effective anticholinergic agent, and is likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine.
Brompheniramine is metabolised via cytochrome P450 oxidase.
The halogenated alkylamine antihistamines all exhibit optic isomerism and brompheniramine products contain racaemic brompheniramine maleate whereas dexbrompheniramine (Drixoral) is the dextrorotary (right-handed) stereoisomer.
[edit] Side effects
Its effects on the cholinergic system may include side-effects such as drowsiness, sedation, dry mouth, dry throat, blurred vision, and increased heart rate.
[edit] References
- ^ Barondes, Samuel H. (2003). Better Than Prozac. New York: Oxford University Press, 39-40. ISBN 0-19-515130-5.
[edit] External links
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