Tolperisone

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Tolperisone
Systematic (IUPAC) name
2-methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one
Identifiers
CAS number 728-88-1
ATC code M03BX04
PubChem 5511
Chemical data
Formula C16H23NO 
Mol. mass 245.36 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Tolperisone, a piperidine derivative, is a centrally acting muscle relaxant. Brand names include Mydocalm and Mydeton.

[edit] External links

  • Hofer D, Lohberger B, Steinecker B, Schmidt K, Quasthoff S, Schreibmayer W (2006). "A comparative study of the action of tolperisone on seven different voltage dependent sodium channel isoforms.". Eur J Pharmacol 538 (1-3): 5–14. doi:10.1016/j.ejphar.2006.03.034. PMID 16650844. 
  • Kocsis P, Farkas S, Fodor L, Bielik N, Thán M, Kolok S, Gere A, Csejtei M, Tarnawa I (2005). "Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels.". J Pharmacol Exp Ther 315 (3): 1237–46. doi:10.1124/jpet.105.089805. PMID 16126840. 
  • Ribi C, Vermeulen C, Hauser C (2003). "Anaphylactic reactions to tolperisone (Mydocalm).". Swiss Med Wkly 133 (25-26): 369–71. PMID 12947534. 
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Skeletal Muscle relaxants (M03)
Peripherally acting
(primarily antinicotinic,
neuromuscular-blocking drugs)
Curare Alkaloids
(Non-Depolarising)
Choline Derivatives
(Depolarising)
Other
Centrally Acting
Other
Directly acting
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