Chlorzoxazone

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Chlorzoxazone
Systematic (IUPAC) name
5-chloro-3H-benzooxazol-2-one
Identifiers
CAS number	95-25-0
ATC code	M03BB03
PubChem	2733
DrugBank	APRD00308
Chemical data
Formula	C7H4ClNO2
Mol. mass	169.565 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	well absorbed
Protein binding	13–18%
Metabolism	hepatic
Half life	1.1 hr
Excretion	urine (<1%)
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	oral

Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold as Parafon Forte, a combination of chlorzoxazone and acetaminophen. Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction.

[edit] External links

• Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF. (2006). "Chlorzoxazone inhibit contraction of rat thoracic aorta.". Eur J Pharmacol. doi:10.1016/j.ejphar.2006.06.063. PMID 16859676. 
• Park J, Kim K, Park P, Ha J (2006). "Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe.". J Clin Pharmacol 46 (1): 109–14. doi:10.1177/0091270005282635. PMID 16397290. 
• Wan J, Ernstgård L, Song B, Shoaf S (2006). "Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats.". J Pharm Pharmacol 58 (1): 51–61. doi:10.1211/jpp.58.1.0007. PMID 16393464. 

v • d • e Skeletal Muscle relaxants (M03) Peripherally acting (primarily antinicotinic, neuromuscular-blocking drugs) Curare Alkaloids (Non-Depolarising) Alcuronium, Dimethyltubocurarine, Tubocurarine quaternary ammonium compounds (Non-Depolarising) Atracurium, Cisatracurium, Doxacurium chloride, Fazadinium bromide, Gallamine, Hexafluronium, Metocurine, Mivacurium chloride, Pancuronium, Pipecuronium bromide, Rocuronium bromide,Vecuronium Choline Derivatives (Depolarising) Suxamethonium, Succinylcholine Other Botulinum toxin Centrally Acting Carbamic acid esters Carisoprodol, Febarbamate, Meprobamate, Methocarbamol, Phenprobamate, Styramate, Tybamate Benzodiazepines Bentazepam, Diazepam, Lorazepam, Nitrazepam, Tetrazepam Anticholinergics (Antimuscarinics) Cyclobenzaprine, Orphenadrine, Trazadone Other Baclofen, Chlormezanone, Chlorzoxazone, Donepezil, Mephenesin, Mephenoxalone, Phenyramidol, Pridinol, Quinine, Thiocolchicoside, Tizanidine, Tolperisone Directly acting Dantrolene