Chlormezanone

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Chlormezanone
Systematic (IUPAC) name
2-(4-chlorophenyl)-3-methyl-1,1-dioxo-1,3-thiazinan-4-one
Identifiers
CAS number 80-77-3
ATC code M03BB02
PubChem 2717
DrugBank APRD00865
Chemical data
Formula C11H12ClNO3S 
Mol. mass 273.737 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 40.5 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status

?(US)
Routes Oral

Chlormezanone (marketed under the brandname Trancopal) is a drug used as an anxiolytic and a muscle relaxant.

Its use was discontinued in many countries in 1996, due to rare but serious cases of toxic epidermal necrolysis.

[edit] References

  • Wollina U, Hipler U, Seeling A, Oelschlager H. "Investigations of interactions of chlormezanone racemate and its enantiomers on human keratinocytes and human leucoytes in vitro.". Skin Pharmacol Physiol 18 (3): 132–8. doi:10.1159/000084910. PMID 15897685. 
  • Seeling A, Oelschläger H, Rothley D (2000). "Important pharmaceutical-chemical characteristics of the central muscle relaxant chlormezanone". Pharmazie 55 (4): 293–6. PMID 10798243. 
  • Oelschläger H, Klinger W, Rothley D, Seeling A, Bockhard H, Hofmann B, Machts H, Riederer H, Rackur H (1998). "[Cleavage and biotransformation of the central muscle relaxant chlormezanone]". Pharmazie 53 (9): 620–4. PMID 9770210. 
  • Gautier V, Vincon G, Demotes-Mainard F, Albin H (1990). "[Pharmacokinetics of chlormezanone in healthy volunteers] (original in French)". Pharmazie 45 (4): 315–9. PMID 2399514. 
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Skeletal Muscle relaxants (M03)
Peripherally acting
(primarily antinicotinic,
neuromuscular-blocking drugs)
Curare Alkaloids
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Choline Derivatives
(Depolarising)
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Centrally Acting
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