Space of Disse

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Space of Disse
Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm. Scanning electron micrograph by Robin Fraser, University of Otago.
Dorlands/Elsevier	s_16/12745272

The space of Disse (or perisinusoidal space) is a location in the liver between a hepatocyte and a sinusoid. It contains the blood plasma. Microvilli of hepatocytes extend into this space, allowing proteins and other plasma components from the sinusoids to be taken up by the hepatocytes. This space may be obliterated in liver disease, leading to decreased uptake by hepatocytes of nutrients and wastes (like bilirubin, for example).

The Space of Disse also contains Ito cells which store fat or fat soluble vitamins (like vitamin A). Excessive intake of fat soluble vitamins can lead to pathologically enlarged Ito cells, which can form collagen and lead to fibrosis and cirrhosis.

The Space of Disse was named after German anatomist, Joseph Disse (1852–1912). ^[1]

[edit] References

1. ^ Haubrich WS (2004). "Disse of the space of Disse". Gastroenterology 127 (6): 1684. PMID 15578505. 

[edit] External links

• UIUC Histology Subject 1317
• Histology at BU 22103loa - "Ultrastructure of the Cell: hepatocytes and sinusoids, sinusoid and space of Disse"
• Histology at BU 15204loa - "Liver, Gall Bladder, and Pancreas: liver; sinusoids and Kupffer cells"
• Organology at UC Davis digestive/mammal/liver5/liver7 - "Mammal, liver (EM, Low)"

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