Ribitol 2-dehydrogenase

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In enzymology, a ribitol 2-dehydrogenase (EC 1.1.1.56) is an enzyme that catalyzes the chemical reaction

ribitol + NAD⁺ $\rightleftharpoons$ D-ribulose + NADH + H⁺

Thus, the two substrates of this enzyme are ribitol and NAD⁺, whereas its 3 products are D-ribulose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ribitol:NAD+ 2-oxidoreductase. Other names in common use include adonitol dehydrogenase, ribitol dehydrogenase A (wild type), ribitol dehydrogenase B (mutant enzyme with different properties), and ribitol dehydrogenase D (mutant enzyme with different properties). This enzyme participates in pentose and glucuronate interconversions.

[edit] References

IUBMB entry for 1.1.1.56
BRENDA references for 1.1.1.56 (Recommended.)
PubMed references for 1.1.1.56
PubMed Central references for 1.1.1.56
Google Scholar references for 1.1.1.56
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Nordlie RC and Fromm HJ (1959). "Ribitol dehydrogenase. II. Studies on the reaction mechanism". J. Biol. Chem. 234: 2523–2531.
Wood WA, McDonough MJ and Jacobs LB (1961). "Ribitol and D-arabitol utilization by Aerobacter aerogenes". J. Biol. Chem. 236: 2190–2195.