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Log page index: User:ProteinBoxBot/PBB_Log_Index
[edit] Protein Status Quick Log - Date: 19:12, 10 November 2007 (UTC)
[edit] Proteins without matches (15)
[edit] Proteins with a High Potential Match (10)
[edit] Created (7)
[edit] Manual Inspection (Page not found) (18)
[edit] Protein Status Grid - Date: 19:12, 10 November 2007 (UTC)
[edit] Vebose Log - Date: 19:12, 10 November 2007 (UTC)
- INFO: Beginning work on ADRA1A... {November 10, 2007 10:42:05 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:43:44 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Adrenergic, alpha-1A-, receptor
| HGNCid = 277
| Symbol = ADRA1A
| AltSymbols =; ADRA1C; ADRA1L1; ALPHA1AAR
| OMIM = 104221
| ECnumber =
| Homologene = 68078
| MGIid = 104773
| GeneAtlas_image1 = PBB_GE_ADRA1A_211492_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ADRA1A_211490_at_tn.png
| GeneAtlas_image3 = PBB_GE_ADRA1A_211491_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004935 |text = adrenoceptor activity}} {{GNF_GO|id=GO:0004937 |text = alpha1-adrenergic receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006939 |text = smooth muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 148
| Hs_Ensembl = ENSG00000120907
| Hs_RefseqProtein = NP_000671
| Hs_RefseqmRNA = NM_000680
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 26661584
| Hs_GenLoc_end = 26778839
| Hs_Uniprot = P35348
| Mm_EntrezGene = 11549
| Mm_Ensembl = ENSMUSG00000045875
| Mm_RefseqmRNA = NM_013461
| Mm_RefseqProtein = NP_038489
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 65589368
| Mm_GenLoc_end = 65687439
| Mm_Uniprot = Q8BUE5
}}
}}
'''Adrenergic, alpha-1A-, receptor''', also known as '''ADRA1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties.<ref>{{cite web | title = Entrez Gene: ADRA1A adrenergic, alpha-1A-, receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=148| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mátyus P, Horváth K |title=Alpha-adrenergic approach in the medical management of benign prostatic hyperplasia. |journal=Med Res Rev |volume=17 |issue= 6 |pages= 523-35 |year= 1998 |pmid= 9359081 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AMACR... {November 10, 2007 11:03:56 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:04:08 AM PST}
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| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Alpha-methylacyl-CoA racemase
| HGNCid = 451
| Symbol = AMACR
| AltSymbols =; RACE
| OMIM = 604489
| ECnumber =
| Homologene = 7410
| MGIid = 1098273
| Function = {{GNF_GO|id=GO:0008111 |text = alpha-methylacyl-CoA racemase activity}} {{GNF_GO|id=GO:0016829 |text = lyase activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005777 |text = peroxisome}}
| Process = {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 23600
| Hs_Ensembl =
| Hs_RefseqProtein = NP_055139
| Hs_RefseqmRNA = NM_014324
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 17117
| Mm_Ensembl = ENSMUSG00000022244
| Mm_RefseqmRNA = NM_008537
| Mm_RefseqProtein = NP_032563
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 10926481
| Mm_GenLoc_end = 10941349
| Mm_Uniprot = Q3TUS8
}}
}}
'''Alpha-methylacyl-CoA racemase''', also known as '''AMACR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Jiang Z, Woda BA, Wu CL, Yang XJ |title=Discovery and clinical application of a novel prostate cancer marker: alpha-methylacyl CoA racemase (P504S). |journal=Am. J. Clin. Pathol. |volume=122 |issue= 2 |pages= 275-89 |year= 2004 |pmid= 15323145 |doi= 10.1309/EJUY-UQPE-X1MG-68MK }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AMPD1... {November 10, 2007 10:44:46 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:45:35 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Adenosine monophosphate deaminase 1 (isoform M)
| HGNCid = 468
| Symbol = AMPD1
| AltSymbols =; MAD; MADA
| OMIM = 102770
| ECnumber =
| Homologene = 20
| MGIid = 88015
| GeneAtlas_image1 = PBB_GE_AMPD1_206121_at_tn.png
| Function = {{GNF_GO|id=GO:0003876 |text = AMP deaminase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0009117 |text = nucleotide metabolic process}} {{GNF_GO|id=GO:0009168 |text = purine ribonucleoside monophosphate biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 270
| Hs_Ensembl = ENSG00000116748
| Hs_RefseqProtein = NP_000027
| Hs_RefseqmRNA = NM_000036
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 115017245
| Hs_GenLoc_end = 115039762
| Hs_Uniprot = P23109
| Mm_EntrezGene = 229665
| Mm_Ensembl = ENSMUSG00000070385
| Mm_RefseqmRNA = NM_001033303
| Mm_RefseqProtein = NP_001028475
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 103203157
| Mm_GenLoc_end = 103228775
| Mm_Uniprot = Q3V1D3
}}
}}
'''Adenosine monophosphate deaminase 1 (isoform M)''', also known as '''AMPD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human.<ref>{{cite web | title = Entrez Gene: AMPD1 adenosine monophosphate deaminase 1 (isoform M)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=270| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AP1G1... {November 10, 2007 10:43:44 AM PST}
- UPLOAD: Added new Image to wiki:
{November 10, 2007 10:44:23 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 10:44:38 AM PST}
- CREATED: Created new protein page: AP1G1 {November 10, 2007 10:44:46 AM PST}
- INFO: Beginning work on APBA1... {November 10, 2007 10:45:35 AM PST}
- UPLOAD: Added new Image to wiki:
{November 10, 2007 10:46:10 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:46:28 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_APBA1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aqc.
| PDB = {{PDB2|1aqc}}, {{PDB2|1u37}}, {{PDB2|1u38}}, {{PDB2|1u39}}, {{PDB2|1u3b}}, {{PDB2|1x11}}, {{PDB2|1x45}}, {{PDB2|1y7n}}
| Name = Amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)
| HGNCid = 578
| Symbol = APBA1
| AltSymbols =; D9S411E; MINT1; X11; X11A; X11ALPHA
| OMIM = 602414
| ECnumber =
| Homologene = 897
| MGIid = 1860297
| GeneAtlas_image1 = PBB_GE_APBA1_206679_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008088 |text = axon cargo transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 320
| Hs_Ensembl = ENSG00000107282
| Hs_RefseqProtein = NP_001154
| Hs_RefseqmRNA = NM_001163
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 71235022
| Hs_GenLoc_end = 71477042
| Hs_Uniprot = Q02410
| Mm_EntrezGene = 319924
| Mm_Ensembl = ENSMUSG00000024897
| Mm_RefseqmRNA = NM_177034
| Mm_RefseqProtein = NP_796008
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 23825973
| Mm_GenLoc_end = 24016694
| Mm_Uniprot =
}}
}}
'''Amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)''', also known as '''APBA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.<ref>{{cite web | title = Entrez Gene: APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=320| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=van der Geer P, Pawson T |title=The PTB domain: a new protein module implicated in signal transduction. |journal=Trends Biochem. Sci. |volume=20 |issue= 7 |pages= 277-80 |year= 1995 |pmid= 7545337 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ATN1... {November 10, 2007 10:48:24 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:49:41 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Atrophin 1
| HGNCid = 3033
| Symbol = ATN1
| AltSymbols =; B37; D12S755E; DRPLA; NOD
| OMIM = 607462
| ECnumber =
| Homologene = 1461
| MGIid = 104725
| GeneAtlas_image1 = PBB_GE_ATN1_40489_at_tn.png
| GeneAtlas_image2 = PBB_GE_ATN1_208871_at_tn.png
| GeneAtlas_image3 = PBB_GE_ATN1_211076_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0050827 |text = toxin receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0008219 |text = cell death}} {{GNF_GO|id=GO:0009404 |text = toxin metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1822
| Hs_Ensembl = ENSG00000111676
| Hs_RefseqProtein = NP_001007027
| Hs_RefseqmRNA = NM_001007026
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 6903887
| Hs_GenLoc_end = 6921743
| Hs_Uniprot = P54259
| Mm_EntrezGene = 13498
| Mm_Ensembl = ENSMUSG00000004263
| Mm_RefseqmRNA = XM_981322
| Mm_RefseqProtein = XP_986416
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 124708161
| Mm_GenLoc_end = 124722106
| Mm_Uniprot =
}}
}}
'''Atrophin 1''', also known as '''ATN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Dentatorubral pallidoluysian atrophy is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion of a trinucleotide repeat within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.<ref>{{cite web | title = Entrez Gene: ATN1 atrophin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1822| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ATP2C1... {November 10, 2007 11:04:08 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:05:10 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATPase, Ca++ transporting, type 2C, member 1
| HGNCid = 13211
| Symbol = ATP2C1
| AltSymbols =; ATP2C1A; BCPM; HHD; KIAA1347; PMR1; SPCA1; hSPCA1
| OMIM = 604384
| ECnumber =
| Homologene = 56672
| MGIid = 1889008
| GeneAtlas_image1 = PBB_GE_ATP2C1_209934_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ATP2C1_209935_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005388 |text = calcium-transporting ATPase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016820 |text = hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005802 |text = trans-Golgi network}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0016339 |text = calcium-dependent cell-cell adhesion}} {{GNF_GO|id=GO:0031532 |text = actin cytoskeleton reorganization}} {{GNF_GO|id=GO:0032468 |text = Golgi calcium ion homeostasis}} {{GNF_GO|id=GO:0032472 |text = Golgi calcium ion transport}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 27032
| Hs_Ensembl = ENSG00000017260
| Hs_RefseqProtein = NP_001001485
| Hs_RefseqmRNA = NM_001001485
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 132095712
| Hs_GenLoc_end = 132218243
| Hs_Uniprot = P98194
| Mm_EntrezGene = 235574
| Mm_Ensembl = ENSMUSG00000032570
| Mm_RefseqmRNA = XM_981296
| Mm_RefseqProtein = XP_986390
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 105269458
| Mm_GenLoc_end = 105379247
| Mm_Uniprot = Q3UWW0
}}
}}
'''ATPase, Ca++ transporting, type 2C, member 1''', also known as '''ATP2C1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: ATP2C1 ATPase, Ca++ transporting, type 2C, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27032| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Missiaen L, Raeymaekers L, Dode L, ''et al.'' |title=SPCA1 pumps and Hailey-Hailey disease. |journal=Biochem. Biophys. Res. Commun. |volume=322 |issue= 4 |pages= 1204-13 |year= 2004 |pmid= 15336968 |doi= 10.1016/j.bbrc.2004.07.128 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CYP27A1... {November 10, 2007 10:46:28 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:47:04 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 27, subfamily A, polypeptide 1
| HGNCid = 2605
| Symbol = CYP27A1
| AltSymbols =; CP27; CTX; CYP27
| OMIM = 606530
| ECnumber =
| Homologene = 36040
| MGIid = 88594
| GeneAtlas_image1 = PBB_GE_CYP27A1_203979_at_tn.png
| Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0008395 |text = steroid hydroxylase activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0047749 |text = cholestanetriol 26-monooxygenase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1593
| Hs_Ensembl = ENSG00000135929
| Hs_RefseqProtein = NP_000775
| Hs_RefseqmRNA = NM_000784
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 219354745
| Hs_GenLoc_end = 219388254
| Hs_Uniprot = Q02318
| Mm_EntrezGene = 104086
| Mm_Ensembl = ENSMUSG00000026170
| Mm_RefseqmRNA = NM_024264
| Mm_RefseqProtein = NP_077226
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 74646781
| Mm_GenLoc_end = 74671097
| Mm_Uniprot = Q99LX3
}}
}}
'''Cytochrome P450, family 27, subfamily A, polypeptide 1''', also known as '''CYP27A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.<ref>{{cite web | title = Entrez Gene: CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1593| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DICER1... {November 10, 2007 11:03:39 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:03:56 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dicer1, Dcr-1 homolog (Drosophila)
| HGNCid = 17098
| Symbol = DICER1
| AltSymbols =; Dicer; HERNA; KIAA0928
| OMIM = 606241
| ECnumber =
| Homologene = 13251
| MGIid = 2177178
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003725 |text = double-stranded RNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004525 |text = ribonuclease III activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006396 |text = RNA processing}} {{GNF_GO|id=GO:0019827 |text = stem cell maintenance}} {{GNF_GO|id=GO:0030324 |text = lung development}} {{GNF_GO|id=GO:0030422 |text = RNA interference, production of siRNA}} {{GNF_GO|id=GO:0030423 |text = RNA interference, targeting of mRNA for destruction}} {{GNF_GO|id=GO:0035116 |text = embryonic hindlimb morphogenesis}} {{GNF_GO|id=GO:0035196 |text = miRNA-mediated gene silencing, production of miRNAs}} {{GNF_GO|id=GO:0048754 |text = branching morphogenesis of a tube}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 23405
| Hs_Ensembl =
| Hs_RefseqProtein = NP_085124
| Hs_RefseqmRNA = NM_030621
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 192119
| Mm_Ensembl = ENSMUSG00000041415
| Mm_RefseqmRNA = NM_148948
| Mm_RefseqProtein = NP_683750
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 105092486
| Mm_GenLoc_end = 105152987
| Mm_Uniprot = Q3UUV8
}}
}}
'''Dicer1, Dcr-1 homolog (Drosophila)''', also known as '''DICER1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Two transcript variants encoding the same protein have been identified for this gene.<ref>{{cite web | title = Entrez Gene: DICER1 Dicer1, Dcr-1 homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23405| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DLG2... {November 10, 2007 10:47:04 AM PST}
- UPLOAD: Added new Image to wiki:
{November 10, 2007 10:47:57 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 10:48:16 AM PST}
- CREATED: Created new protein page: DLG2 {November 10, 2007 10:48:24 AM PST}
- INFO: Beginning work on EPHA4... {November 10, 2007 10:49:41 AM PST}
- UPLOAD: Added new Image to wiki:
{November 10, 2007 10:50:45 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:51:01 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EPHA4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b0x.
| PDB = {{PDB2|1b0x}}, {{PDB2|2hel}}
| Name = EPH receptor A4
| HGNCid = 3388
| Symbol = EPHA4
| AltSymbols =; HEK8; SEK; TYRO1
| OMIM = 602188
| ECnumber =
| Homologene = 20933
| MGIid = 98277
| GeneAtlas_image1 = PBB_GE_EPHA4_206114_at_tn.png
| GeneAtlas_image2 = PBB_GE_EPHA4_gnf1h07687_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005003 |text = ephrin receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007628 |text = adult walking behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2043
| Hs_Ensembl = ENSG00000116106
| Hs_RefseqProtein = NP_004429
| Hs_RefseqmRNA = NM_004438
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 221990993
| Hs_GenLoc_end = 222145254
| Hs_Uniprot = P54764
| Mm_EntrezGene = 13838
| Mm_Ensembl = ENSMUSG00000026235
| Mm_RefseqmRNA = NM_007936
| Mm_RefseqProtein = NP_031962
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 77250333
| Mm_GenLoc_end = 77398236
| Mm_Uniprot = Q3V1W9
}}
}}
'''EPH receptor A4''', also known as '''EPHA4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.<ref>{{cite web | title = Entrez Gene: EPHA4 EPH receptor A4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2043| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309-45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
*{{cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151-81 |year= 1998 |pmid= 9576626 |doi= }}
*{{cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033-44 |year= 1999 |pmid= 10207129 |doi= }}
*{{cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177-244 |year= 2000 |pmid= 10730216 |doi= }}
*{{cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993-1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635 }}
*{{cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155-64 |year= 2001 |pmid= 11256076 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on F13B... {November 10, 2007 10:51:01 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 10:51:33 AM PST}
- CREATED: Created new protein page: F13B {November 10, 2007 10:51:42 AM PST}
- INFO: Beginning work on FAH... {November 10, 2007 10:51:42 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:52:12 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Fumarylacetoacetate hydrolase (fumarylacetoacetase)
| HGNCid = 3579
| Symbol = FAH
| AltSymbols =;
| OMIM = 276700
| ECnumber =
| Homologene = 110
| MGIid = 95482
| GeneAtlas_image1 = PBB_GE_FAH_202862_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004334 |text = fumarylacetoacetase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006527 |text = arginine catabolic process}} {{GNF_GO|id=GO:0006559 |text = L-phenylalanine catabolic process}} {{GNF_GO|id=GO:0006572 |text = tyrosine catabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0009072 |text = aromatic amino acid family metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2184
| Hs_Ensembl = ENSG00000103876
| Hs_RefseqProtein = NP_000128
| Hs_RefseqmRNA = NM_000137
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 78232191
| Hs_GenLoc_end = 78265740
| Hs_Uniprot = P16930
| Mm_EntrezGene = 14085
| Mm_Ensembl = ENSMUSG00000030630
| Mm_RefseqmRNA = NM_010176
| Mm_RefseqProtein = NP_034306
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 84461344
| Mm_GenLoc_end = 84481937
| Mm_Uniprot = Q3TY87
}}
}}
'''Fumarylacetoacetate hydrolase (fumarylacetoacetase)''', also known as '''FAH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the last enzyme in the tyrosine catabolism pathway. FAH deficiency is associated with Type 1 hereditary tyrosinemia (HT).<ref>{{cite web | title = Entrez Gene: FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2184| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=St-Louis M, Tanguay RM |title=Mutations in the fumarylacetoacetate hydrolase gene causing hereditary tyrosinemia type I: overview. |journal=Hum. Mutat. |volume=9 |issue= 4 |pages= 291-9 |year= 1997 |pmid= 9101289 |doi= 10.1002/(SICI)1098-1004(1997)9:4<291::AID-HUMU1>3.0.CO;2-9 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FCGRT... {November 10, 2007 10:54:42 AM PST}
- UPLOAD: Added new Image to wiki:
{November 10, 2007 10:55:15 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 10:55:26 AM PST}
- CREATED: Created new protein page: FCGRT {November 10, 2007 10:55:34 AM PST}
- INFO: Beginning work on FLNC... {November 10, 2007 10:55:34 AM PST}
- UPLOAD: Added new Image to wiki:
{November 10, 2007 10:56:06 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:56:31 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FLNC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1v05.
| PDB = {{PDB2|1v05}}, {{PDB2|2brq}}, {{PDB2|2d7m}}, {{PDB2|2d7n}}, {{PDB2|2d7o}}, {{PDB2|2d7p}}, {{PDB2|2d7q}}
| Name = Filamin C, gamma (actin binding protein 280)
| HGNCid = 3756
| Symbol = FLNC
| AltSymbols =; ABP-280; ABP280A; ABPA; ABPL; FLJ10186; FLN2
| OMIM = 102565
| ECnumber =
| Homologene = 37481
| MGIid = 95557
| GeneAtlas_image1 = PBB_GE_FLNC_207876_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2318
| Hs_Ensembl = ENSG00000128591
| Hs_RefseqProtein = NP_001449
| Hs_RefseqmRNA = NM_001458
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 128257719
| Hs_GenLoc_end = 128286568
| Hs_Uniprot = Q14315
| Mm_EntrezGene = 68794
| Mm_Ensembl = ENSMUSG00000068699
| Mm_RefseqmRNA = XM_284175
| Mm_RefseqProtein = XP_284175
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 29383469
| Mm_GenLoc_end = 29411891
| Mm_Uniprot = Q8VHX6
}}
}}
'''Filamin C, gamma (actin binding protein 280)''', also known as '''FLNC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain.<ref>{{cite web | title = Entrez Gene: FLNC filamin C, gamma (actin binding protein 280)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2318| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Stossel TP, Condeelis J, Cooley L, ''et al.'' |title=Filamins as integrators of cell mechanics and signalling. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 2 |pages= 138-45 |year= 2001 |pmid= 11252955 |doi= 10.1038/35052082 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GALNS... {November 10, 2007 10:56:31 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:57:15 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Galactosamine (N-acetyl)-6-sulfate sulfatase (Morquio syndrome, mucopolysaccharidosis type IVA)
| HGNCid = 4122
| Symbol = GALNS
| AltSymbols =; GAS; GALNAC6S; MPS4A
| OMIM = 253000
| ECnumber =
| Homologene = 55468
| MGIid = 1355303
| GeneAtlas_image1 = PBB_GE_GALNS_206335_at_tn.png
| Function = {{GNF_GO|id=GO:0003943 |text = N-acetylgalactosamine-4-sulfatase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008484 |text = sulfuric ester hydrolase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005764 |text = lysosome}}
| Process = {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0030203 |text = glycosaminoglycan metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2588
| Hs_Ensembl = ENSG00000141012
| Hs_RefseqProtein = NP_000503
| Hs_RefseqmRNA = NM_000512
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 87407644
| Hs_GenLoc_end = 87450885
| Hs_Uniprot = P34059
| Mm_EntrezGene = 50917
| Mm_Ensembl = ENSMUSG00000015027
| Mm_RefseqmRNA = NM_016722
| Mm_RefseqProtein = NP_057931
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 125464328
| Mm_GenLoc_end = 125497494
| Mm_Uniprot = Q571E4
}}
}}
'''Galactosamine (N-acetyl)-6-sulfate sulfatase (Morquio syndrome, mucopolysaccharidosis type IVA)''', also known as '''GALNS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder.<ref>{{cite web | title = Entrez Gene: GALNS galactosamine (N-acetyl)-6-sulfate sulfatase (Morquio syndrome, mucopolysaccharidosis type IVA)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2588| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GAS6... {November 10, 2007 10:57:15 AM PST}
- UPLOAD: Added new Image to wiki:
{November 10, 2007 10:57:28 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 10:57:44 AM PST}
- CREATED: Created new protein page: GAS6 {November 10, 2007 10:57:53 AM PST}
- INFO: Beginning work on GP1BB... {November 10, 2007 10:57:53 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:58:06 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glycoprotein Ib (platelet), beta polypeptide
| HGNCid = 4440
| Symbol = GP1BB
| AltSymbols =; CD42c
| OMIM = 138720
| ECnumber =
| Homologene = 30972
| MGIid = 107852
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0030168 |text = platelet activation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2812
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000398
| Hs_RefseqmRNA = NM_000407
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 14724
| Mm_Ensembl = ENSMUSG00000050761
| Mm_RefseqmRNA = NM_001001999
| Mm_RefseqProtein = NP_001001999
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 18534285
| Mm_GenLoc_end = 18534929
| Mm_Uniprot = P56400
}}
}}
'''Glycoprotein Ib (platelet), beta polypeptide''', also known as '''GP1BB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal within a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its own imperfect site, the septin 5 gene uses the consensus polyA signal of this gene.<ref>{{cite web | title = Entrez Gene: GP1BB glycoprotein Ib (platelet), beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2812| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kunishima S, Kamiya T, Saito H |title=Genetic abnormalities of Bernard-Soulier syndrome. |journal=Int. J. Hematol. |volume=76 |issue= 4 |pages= 319-27 |year= 2003 |pmid= 12463594 |doi= }}
*{{cite journal | author=Clemetson KJ |title=A short history of platelet glycoprotein Ib complex. |journal=Thromb. Haemost. |volume=98 |issue= 1 |pages= 63-8 |year= 2007 |pmid= 17597992 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GPR30... {November 10, 2007 10:58:06 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:59:09 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G protein-coupled receptor 30
| HGNCid = 4485
| Symbol = GPR30
| AltSymbols =; CMKRL2; DRY12; FEG-1; GPCR-Br; LERGU; LERGU2; LyGPR; MGC99678
| OMIM = 601805
| ECnumber =
| Homologene = 15855
| MGIid = 1924104
| GeneAtlas_image1 = PBB_GE_GPR30_210640_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GPR30_211829_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0045028 |text = purinergic nucleotide receptor activity, G-protein coupled}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2852
| Hs_Ensembl = ENSG00000164850
| Hs_RefseqProtein = NP_001035055
| Hs_RefseqmRNA = NM_001039966
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 1093038
| Hs_GenLoc_end = 1099977
| Hs_Uniprot = Q99527
| Mm_EntrezGene = 76854
| Mm_Ensembl = ENSMUSG00000053647
| Mm_RefseqmRNA = NM_029771
| Mm_RefseqProtein = NP_084047
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 139676821
| Mm_GenLoc_end = 139681430
| Mm_Uniprot = Q8BMP4
}}
}}
'''G protein-coupled receptor 30''', also known as '''GPR30''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.<ref>{{cite web | title = Entrez Gene: GPR30 G protein-coupled receptor 30| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2852| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Filardo EJ |title=Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. |journal=J. Steroid Biochem. Mol. Biol. |volume=80 |issue= 2 |pages= 231-8 |year= 2002 |pmid= 11897506 |doi= }}
*{{cite journal | author=Filardo EJ, Thomas P |title=GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release. |journal=Trends Endocrinol. Metab. |volume=16 |issue= 8 |pages= 362-7 |year= 2005 |pmid= 16125968 |doi= 10.1016/j.tem.2005.08.005 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GTF2A1... {November 10, 2007 10:59:09 AM PST}
- UPLOAD: Added new Image to wiki:
{November 10, 2007 10:59:47 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:00:20 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GTF2A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nvp.
| PDB = {{PDB2|1nvp}}
| Name = General transcription factor IIA, 1, 19/37kDa
| HGNCid = 4646
| Symbol = GTF2A1
| AltSymbols =; MGC129969; MGC129970; TF2A1; TFIIA
| OMIM = 600520
| ECnumber =
| Homologene = 56331
| MGIid = 1933277
| GeneAtlas_image1 = PBB_GE_GTF2A1_206521_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016251 |text = general RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0016986 |text = transcription initiation factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005672 |text = transcription factor TFIIA complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2957
| Hs_Ensembl = ENSG00000165417
| Hs_RefseqProtein = NP_056943
| Hs_RefseqmRNA = NM_015859
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 80716147
| Hs_GenLoc_end = 80757328
| Hs_Uniprot = P52655
| Mm_EntrezGene = 83602
| Mm_Ensembl = ENSMUSG00000020962
| Mm_RefseqmRNA = NM_031391
| Mm_RefseqProtein = NP_113568
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 91964245
| Mm_GenLoc_end = 91995136
| Mm_Uniprot = Q0VGZ0
}}
}}
'''General transcription factor IIA, 1, 19/37kDa''', also known as '''GTF2A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HK1... {November 10, 2007 11:00:20 AM PST}
- UPLOAD: Added new Image to wiki:
{November 10, 2007 11:00:49 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:01:08 AM PST}
- CREATED: Created new protein page: HK1 {November 10, 2007 11:01:17 AM PST}
- INFO: Beginning work on HRG... {November 10, 2007 11:01:17 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:02:16 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Histidine-rich glycoprotein
| HGNCid = 5181
| Symbol = HRG
| AltSymbols =; DKFZp779H1622; HPRG; HRGP
| OMIM = 142640
| ECnumber =
| Homologene = 30973
| MGIid = 2146636
| GeneAtlas_image1 = PBB_GE_HRG_31835_at_tn.png
| GeneAtlas_image2 = PBB_GE_HRG_206226_at_tn.png
| Function = {{GNF_GO|id=GO:0004869 |text = cysteine protease inhibitor activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3273
| Hs_Ensembl = ENSG00000113905
| Hs_RefseqProtein = NP_000403
| Hs_RefseqmRNA = NM_000412
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 187866487
| Hs_GenLoc_end = 187878718
| Hs_Uniprot = P04196
| Mm_EntrezGene = 94175
| Mm_Ensembl = ENSMUSG00000022877
| Mm_RefseqmRNA = NM_053176
| Mm_RefseqProtein = NP_444406
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 22866448
| Mm_GenLoc_end = 22876990
| Mm_Uniprot =
}}
}}
'''Histidine-rich glycoprotein''', also known as '''HRG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.<ref>{{cite web | title = Entrez Gene: HRG histidine-rich glycoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3273| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HSD3B1... {November 10, 2007 11:02:16 AM PST}
- CREATE: Found no pages, creating new page. {November 10, 2007 11:02:48 AM PST}
- CREATED: Created new protein page: HSD3B1 {November 10, 2007 11:02:55 AM PST}
- INFO: Beginning work on HSPE1... {November 10, 2007 11:02:55 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:03:39 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Heat shock 10kDa protein 1 (chaperonin 10)
| HGNCid = 5269
| Symbol = HSPE1
| AltSymbols =; CPN10; GROES; HSP10
| OMIM = 600141
| ECnumber =
| Homologene = 20500
| MGIid = 104680
| GeneAtlas_image1 = PBB_GE_HSPE1_205133_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}} {{GNF_GO|id=GO:0051087 |text = chaperone binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006919 |text = caspase activation}} {{GNF_GO|id=GO:0006986 |text = response to unfolded protein}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3336
| Hs_Ensembl = ENSG00000115541
| Hs_RefseqProtein = NP_002148
| Hs_RefseqmRNA = NM_002157
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 198073292
| Hs_GenLoc_end = 198076349
| Hs_Uniprot = P61604
| Mm_EntrezGene = 15528
| Mm_Ensembl = ENSMUSG00000073676
| Mm_RefseqmRNA = NM_008303
| Mm_RefseqProtein = NP_032329
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 55033596
| Mm_GenLoc_end = 55035665
| Mm_Uniprot = Q4KL76
}}
}}
'''Heat shock 10kDa protein 1 (chaperonin 10)''', also known as '''HSPE1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Czarnecka AM, Campanella C, Zummo G, Cappello F |title=Heat shock protein 10 and signal transduction: a "capsula eburnea" of carcinogenesis? |journal=Cell Stress Chaperones |volume=11 |issue= 4 |pages= 287-94 |year= 2007 |pmid= 17278877 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MS4A2... {November 10, 2007 10:52:12 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 10:54:42 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
| HGNCid = 7316
| Symbol = MS4A2
| AltSymbols =; MS4A1; APY; ATOPY; FCER1B; FCERI; IGEL; IGER; IGHER
| OMIM = 147138
| ECnumber =
| Homologene = 112
| MGIid = 95495
| GeneAtlas_image1 = PBB_GE_MS4A2_207497_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MS4A2_207496_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005262 |text = calcium channel activity}} {{GNF_GO|id=GO:0019863 |text = IgE binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006959 |text = humoral immune response}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2206
| Hs_Ensembl = ENSG00000149534
| Hs_RefseqProtein = NP_000130
| Hs_RefseqmRNA = NM_000139
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 59612713
| Hs_GenLoc_end = 59622593
| Hs_Uniprot = Q01362
| Mm_EntrezGene = 14126
| Mm_Ensembl = ENSMUSG00000024680
| Mm_RefseqmRNA = NM_013516
| Mm_RefseqProtein = NP_038544
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 11684238
| Mm_GenLoc_end = 11690688
| Mm_Uniprot = P20490
}}
}}
'''Membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)''', also known as '''MS4A2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.<ref>{{cite web | title = Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2206| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Jouvin MH, Numerof RP, Kinet JP |title=Signal transduction through the conserved motifs of the high affinity IgE receptor Fc epsilon RI. |journal=Semin. Immunol. |volume=7 |issue= 1 |pages= 29-35 |year= 1995 |pmid= 7612892 |doi= }}
*{{cite journal | author=Wilson BS, Pfeiffer JR, Oliver JM |title=FcepsilonRI signaling observed from the inside of the mast cell membrane. |journal=Mol. Immunol. |volume=38 |issue= 16-18 |pages= 1259-68 |year= 2003 |pmid= 12217393 |doi= }}
*{{cite journal | author=Kraft S, Rana S, Jouvin MH, Kinet JP |title=The role of the FcepsilonRI beta-chain in allergic diseases. |journal=Int. Arch. Allergy Immunol. |volume=135 |issue= 1 |pages= 62-72 |year= 2004 |pmid= 15316148 |doi= 10.1159/000080231 }}
}}
{{refend}}
{{protein-stub}}
end log.
