EPH receptor A4

From Wikipedia, the free encyclopedia

EPH receptor A4

PDB rendering based on 1b0x.

Available structures: 1b0x, 2hel

Identifiers

Symbol(s)

EPHA4; HEK8; SEK; TYRO1

External IDs

OMIM: 602188 MGI: 98277 HomoloGene: 20933

Gene ontology
Molecular Function:	• nucleotide binding • receptor activity • ephrin receptor activity • ATP binding • transferase activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• protein amino acid phosphorylation • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • axon guidance • adult walking behavior

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004438 (mRNA)
NP_004429 (protein)

NM_007936 (mRNA)
NP_031962 (protein)

Location

Chr 2: 221.99 - 222.15 Mb

Chr 1: 77.25 - 77.4 Mb

Pubmed search

[1]

[2]

EPH receptor A4, also known as EPHA4, is a human gene.^[1]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.^[1]

[edit] References

^ ^a ^b Entrez Gene: EPHA4 EPH receptor A4.

[edit] Further reading

Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
Fox GM, Holst PL, Chute HT, et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.". Oncogene 10 (5): 897–905. PMID 7898931.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Ellis C, Kasmi F, Ganju P, et al. (1996). "A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn.". Oncogene 12 (8): 1727–36. PMID 8622893.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9–19. PMID 8755474.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403–4. PMID 9267020.
Aasheim HC, Terstappen LW, Logtenberg T (1997). "Regulated expression of the Eph-related receptor tyrosine kinase Hek11 in early human B lymphopoiesis.". Blood 90 (9): 3613–22. PMID 9345045.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Bergemann AD, Zhang L, Chiang MK, et al. (1998). "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube.". Oncogene 16 (4): 471–80. doi:10.1038/sj.onc.1201557. PMID 9484836.
Janis LS, Cassidy RM, Kromer LF (1999). "Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum.". J. Neurosci. 19 (12): 4962–71. PMID 10366629.