User:ProteinBoxBot/PBB Log Wiki 11-8-2007 B-2

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Contents

[edit] Log file for Protein Box Bot

Log page index: User:ProteinBoxBot/PBB_Log_Index

[edit] Protein Status Quick Log - Date: 09:10, 9 November 2007 (UTC)

[edit] Proteins without matches (23)

GNA11 GATA2 CDH3 SNAP23 DYNLL1
MAPK8IP1 ADAMTS4 RIPK2 FCER1A ISG15
CAMK2B CDC6 UBTF EBAG9 CD3G
GABRG2 DAB2 CCNA1 DYRK1A AKR1C3
CDC37 XBP1 DTNBP1

[edit] Proteins with a High Potential Match (2)

CYP2C8 PTGES

[edit] Created (15)

GATA2 SNAP23 MAPK8IP1 ADAMTS4 FCER1A
ISG15 CAMK2B CDC6 EBAG9 CD3G
GABRG2 DAB2 CCNA1 CDC37 XBP1

[edit] Manual Inspection (Page not found) (10)

GNA11 CDH3 DYNLL1 RIPK2 UBTF
DYRK1A AKR1C3 CYP2C8 DTNBP1 PTGES


[edit] Protein Status Grid - Date: 09:10, 9 November 2007 (UTC)

HUGO Symbol Action Summary Target page(s) WP Symbol Search
GNA11 Manual Inspection (Page not found) Other Pages: Guanine nucleotide binding protein (Redirect -> G protein); GNA11 (No Data); GNA-11 (No Data); Gna-11 (No Data); G protein (Unknown Data); [1]
GATA2 Created Other Pages: GATA binding protein 2 (No Data); GATA2 (No Data); MGC2306 (No Data); Mgc2306 (No Data); NFE1B (No Data); Nfe1b (No Data); [2]
CDH3 Manual Inspection (Page not found) Other Pages: Cadherin 3 (No Data); CDH3 (Redirect -> Finlay Air Park); CDHP (No Data); Cdhp (No Data); HJMD (No Data); Hjmd (No Data); PCAD (Redirect -> Plymouth College of Art and Design); Pcad (No Data); Finlay Air Park (Unknown Data); Plymouth College of Art and Design (Unknown Data); [3]
SNAP23 Created Other Pages: Synaptosomal-associated protein (No Data); SNAP23 (No Data); HsT17016 (No Data); Hst17016 (No Data); SNAP23A (No Data); Snap23a (No Data); SNAP23B (No Data); Snap23b (No Data); [4]
DYNLL1 Manual Inspection (Page not found) Other Pages: Dynein (Unknown Data); DYNLL1 (No Data); DLC1 (No Data); Dlc1 (No Data); DLC8 (No Data); Dlc8 (No Data); DNCL1 (No Data); Dncl1 (No Data); DNCLC1 (No Data); Dnclc1 (No Data); LC8 (No Data); Lc8 (No Data); LC8a (No Data); Lc8a (No Data); MGC126137 (No Data); Mgc126137 (No Data); MGC126138 (No Data); Mgc126138 (No Data); PIN (DisAmbig); Pin (DisAmbig); Hdlc1 (No Data); [5]
MAPK8IP1 Created Other Pages: Mitogen-activated protein kinase 8 interacting protein 1 (No Data); MAPK8IP1 (No Data); IB1 (No Data); Ib1 (No Data); JIP-1 (No Data); Jip-1 (No Data); JIP1 (No Data); Jip1 (No Data); PRKM8IP (No Data); Prkm8ip (No Data); [6]
ADAMTS4 Created Other Pages: ADAM metallopeptidase with thrombospondin type 1 motif (No Data); ADAMTS4 (No Data); ADAMTS-2 (No Data); Adamts-2 (No Data); ADAMTS-4 (No Data); Adamts-4 (No Data); ADMP-1 (No Data); Admp-1 (No Data); KIAA0688 (No Data); Kiaa0688 (No Data); [7]
RIPK2 Manual Inspection (Page not found) Other Pages: Receptor-interacting serine-threonine kinase 2 (No Data); RIPK2 (No Data); CCK (DisAmbig); Cck (No Data); CARD3 (No Data); Card3 (No Data); CARDIAK (No Data); Cardiak (No Data); GIG30 (No Data); Gig30 (No Data); RICK (No Data); Rick (DisAmbig); RIP2 (Redirect -> Routing Information Protocol); Rip2 (No Data); Routing Information Protocol (Unknown Data); [8]
FCER1A Created Other Pages: Fc fragment of IgE (No Data); FCER1A (No Data); FCE1A (No Data); Fce1a (No Data); FcERI (No Data); Fceri (No Data); [9]
ISG15 Created Other Pages: ISG15 ubiquitin-like modifier (No Data); ISG15 (No Data); G1P2 (No Data); G1p2 (No Data); IFI15 (No Data); Ifi15 (No Data); UCRP (No Data); Ucrp (No Data); [10]
CAMK2B Created Other Pages: Calcium/calmodulin-dependent protein kinase II beta (No Data); CAMK2B (No Data); CAM2 (No Data); Cam2 (No Data); CAMK2 (No Data); Camk2 (No Data); CAMKB (No Data); Camkb (No Data); MGC29528 (No Data); Mgc29528 (No Data); [11]
CDC6 Created Other Pages: Cell division cycle 6 homolog (No Data); CDC6 (No Data); CDC18L (No Data); Cdc18l (No Data); HsCDC18 (No Data); Hscdc18 (No Data); HsCDC6 (No Data); Hscdc6 (No Data); [12]
UBTF Manual Inspection (Page not found) Other Pages: Upstream binding transcription factor (No Data); UBTF (No Data); NOR-90 (No Data); Nor-90 (No Data); UBF (DisAmbig); Ubf (No Data); [13]
EBAG9 Created Other Pages: Estrogen receptor binding site associated (No Data); EBAG9 (No Data); EB9 (No Data); Eb9 (No Data); PDAF (No Data); Pdaf (No Data); RCAS1 (No Data); Rcas1 (No Data); [14]
CD3G Created Other Pages: CD3g molecule (No Data); CD3G (No Data); CD3-GAMMA (No Data); Cd3-gamma (No Data); MGC138597 (No Data); Mgc138597 (No Data); T3G (No Data); T3g (No Data); [15]
GABRG2 Created Other Pages: Gamma-aminobutyric acid A receptor (No Data); GABRG2 (No Data); CAE2 (No Data); Cae2 (No Data); ECA2 (No Data); Eca2 (No Data); GEFSP3 (No Data); Gefsp3 (No Data); [16]
DAB2 Created Other Pages: Disabled homolog 2 (No Data); DAB2 (No Data); DOC-2 (No Data); Doc-2 (No Data); DOC2 (No Data); Doc2 (No Data); FLJ26626 (No Data); Flj26626 (No Data); [17]
CCNA1 Created Other Pages: Cyclin A1 (No Data); CCNA1 (No Data); [18]
DYRK1A Manual Inspection (Page not found) Other Pages: Dual-specificity tyrosine- -phosphorylation regulated kinase 1A (No Data); DYRK1A (No Data); DYRK (No Data); Dyrk (No Data); DYRK1 (No Data); Dyrk1 (No Data); HP86 (No Data); Hp86 (No Data); MNB (DisAmbig); Mnb (No Data); MNBH (No Data); Mnbh (No Data); [19]
AKR1C3 Manual Inspection (Page not found) Other Pages: Aldo-keto reductase family 1 (No Data); AKR1C3 (No Data); DD3 (Redirect -> Double Dragon 3: The Rosetta Stone); Dd3 (No Data); HA1753 (No Data); Ha1753 (No Data); HAKRB (No Data); Hakrb (No Data); HAKRe (No Data); Hakre (No Data); HSD17B5 (No Data); Hsd17b5 (No Data); KIAA0119 (No Data); Kiaa0119 (No Data); HluPGFS (No Data); Hlupgfs (No Data); Double Dragon 3: The Rosetta Stone (Unknown Data); [20]
CYP2C8 Manual Inspection (Page not found) Other Pages: Cytochrome P450 (Unknown Data); CYP2C8 (Protein Template); CPC8 (No Data); Cpc8 (No Data); [21]
CDC37 Created Other Pages: Cell division cycle 37 homolog (No Data); CDC37 (No Data); P50CDC37 (No Data); P50cdc37 (No Data); [22]
XBP1 Created Other Pages: X-box binding protein 1 (No Data); XBP1 (No Data); TREB5 (No Data); Treb5 (No Data); XBP2 (No Data); Xbp2 (No Data); [23]
DTNBP1 Manual Inspection (Page not found) Other Pages: Dystrobrevin binding protein 1 (No Data); DTNBP1 (No Data); DBND (No Data); Dbnd (No Data); DKFZP564K192 (No Data); Dkfzp564k192 (No Data); FLJ30031 (No Data); Flj30031 (No Data); HPS7 (No Data); Hps7 (No Data); MGC20210 (No Data); Mgc20210 (No Data); My031 (No Data); SDY (DisAmbig); Sdy (No Data); [24]
PTGES Manual Inspection (Page not found) Other Pages: Prostaglandin E synthase (Protein Template); PTGES (No Data); MGC10317 (No Data); Mgc10317 (No Data); MGST-IV (No Data); Mgst-iv (No Data); MGST1-L1 (No Data); Mgst1-l1 (No Data); MGST1L1 (No Data); Mgst1l1 (No Data); PGES (No Data); Pges (No Data); PIG12 (No Data); Pig12 (No Data); PP102 (No Data); Pp102 (No Data); PP1294 (No Data); Pp1294 (No Data); TP53I12 (No Data); Tp53i12 (No Data); [25]

[edit] Vebose Log - Date: 09:10, 9 November 2007 (UTC)

[edit] ADAMTS4

  • INFO: Beginning work on ADAMTS4... {November 9, 2007 12:58:11 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:58:48 AM PST}
  • CREATED: Created new protein page: ADAMTS4 {November 9, 2007 12:58:56 AM PST}

[edit] AKR1C3

  • INFO: Beginning work on AKR1C3... {November 9, 2007 12:50:30 AM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_AKR1C3_image.jpg {November 9, 2007 12:51:20 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:51:46 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_AKR1C3_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ry0.
 | PDB = {{PDB2|1ry0}}, {{PDB2|1ry8}}, {{PDB2|1s1p}}, {{PDB2|1s1r}}, {{PDB2|1s2a}}, {{PDB2|1s2c}}, {{PDB2|1xf0}}, {{PDB2|1zq5}}, {{PDB2|2f38}}, {{PDB2|2fgb}}
 | Name = Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
 | HGNCid = 386
 | Symbol = AKR1C3
 | AltSymbols =; DD3; HA1753; HAKRB; HAKRe; HSD17B5; KIAA0119; hluPGFS
 | OMIM = 603966
 | ECnumber =  
 | Homologene = 81636
 | MGIid = 2145420
 | GeneAtlas_image1 = PBB_GE_AKR1C3_209160_at_tn.png
 | GeneAtlas_image2 = PBB_GE_AKR1C3_211653_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0004033 |text = aldo-keto reductase activity}} {{GNF_GO|id=GO:0004303 |text = estradiol 17-beta-dehydrogenase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0047017 |text = prostaglandin-F synthase activity}} {{GNF_GO|id=GO:0047026 |text = 3-alpha-hydroxysteroid dehydrogenase (A-specific) activity}} {{GNF_GO|id=GO:0047115 |text = trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity}} 
 | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} 
 | Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006693 |text = prostaglandin metabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8644
    | Hs_Ensembl = ENSG00000196139
    | Hs_RefseqProtein = NP_003730
    | Hs_RefseqmRNA = NM_003739
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 5125985
    | Hs_GenLoc_end = 5139878
    | Hs_Uniprot = P42330
    | Mm_EntrezGene = 105349
    | Mm_Ensembl = ENSMUSG00000021214
    | Mm_RefseqmRNA = NM_134066
    | Mm_RefseqProtein = NP_598827
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 4131870
    | Mm_GenLoc_end = 4149877
    | Mm_Uniprot = Q3U538
  }}
}}
'''Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)''', also known as '''AKR1C3''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.<ref>{{cite web | title = Entrez Gene: AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8644| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Lin SX, Shi R, Qiu W, ''et al.'' |title=Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5. |journal=Mol. Cell. Endocrinol. |volume=248 |issue= 1-2 |pages= 38-46 |year= 2006 |pmid= 16480815 |doi= 10.1016/j.mce.2005.11.035 }}
}}
{{refend}}

{{protein-stub}}

[edit] CAMK2B

  • INFO: Beginning work on CAMK2B... {November 9, 2007 12:36:00 AM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_CAMK2B_image.jpg {November 9, 2007 12:37:43 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:37:59 AM PST}
  • CREATED: Created new protein page: CAMK2B {November 9, 2007 12:38:06 AM PST}

[edit] CCNA1

  • INFO: Beginning work on CCNA1... {November 9, 2007 12:55:14 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:55:43 AM PST}
  • CREATED: Created new protein page: CCNA1 {November 9, 2007 12:55:50 AM PST}

[edit] CD3G

  • INFO: Beginning work on CD3G... {November 9, 2007 12:38:06 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:38:41 AM PST}
  • CREATED: Created new protein page: CD3G {November 9, 2007 12:38:48 AM PST}

[edit] CDC37

  • INFO: Beginning work on CDC37... {November 9, 2007 1:01:01 AM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_CDC37_image.jpg {November 9, 2007 1:01:33 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 1:01:43 AM PST}
  • CREATED: Created new protein page: CDC37 {November 9, 2007 1:01:50 AM PST}

[edit] CDC6

  • INFO: Beginning work on CDC6... {November 9, 2007 12:38:48 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:39:44 AM PST}
  • CREATED: Created new protein page: CDC6 {November 9, 2007 12:39:50 AM PST}

[edit] CDH3

  • INFO: Beginning work on CDH3... {November 9, 2007 12:39:50 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:40:32 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Cadherin 3, type 1, P-cadherin (placental)
 | HGNCid = 1762
 | Symbol = CDH3
 | AltSymbols =; CDHP; HJMD; PCAD
 | OMIM = 114021
 | ECnumber =  
 | Homologene = 20425
 | MGIid = 88356
 | GeneAtlas_image1 = PBB_GE_CDH3_203256_at_tn.png
 | Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1001
    | Hs_Ensembl = ENSG00000062038
    | Hs_RefseqProtein = NP_001784
    | Hs_RefseqmRNA = NM_001793
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 67236240
    | Hs_GenLoc_end = 67290440
    | Hs_Uniprot = P22223
    | Mm_EntrezGene = 12560
    | Mm_Ensembl = ENSMUSG00000061048
    | Mm_RefseqmRNA = XM_001000165
    | Mm_RefseqProtein = XP_001000165
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 109400042
    | Mm_GenLoc_end = 109446037
    | Mm_Uniprot = Q80VY6
  }}
}}
'''Cadherin 3, type 1, P-cadherin (placental)''', also known as '''CDH3''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.<ref>{{cite web | title = Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1001| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}

[edit] CYP2C8

  • INFO: Beginning work on CYP2C8... {November 9, 2007 12:40:32 AM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_CYP2C8_image.jpg {November 9, 2007 12:41:05 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:41:15 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_CYP2C8_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1pq2.
 | PDB = {{PDB2|1pq2}}
 | Name = Cytochrome P450, family 2, subfamily C, polypeptide 8
 | HGNCid = 2622
 | Symbol = CYP2C8
 | AltSymbols =; CPC8; P450 MP-12/MP-20
 | OMIM = 601129
 | ECnumber =  
 | Homologene = 68086
 | MGIid = 1917138
 | GeneAtlas_image1 = PBB_GE_CYP2C8_208147_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}} 
 | Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1558
    | Hs_Ensembl = ENSG00000138115
    | Hs_RefseqProtein = NP_000761
    | Hs_RefseqmRNA = NM_000770
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 96786520
    | Hs_GenLoc_end = 96819244
    | Hs_Uniprot = P10632
    | Mm_EntrezGene = 69888
    | Mm_Ensembl = ENSMUSG00000067229
    | Mm_RefseqmRNA = XM_001001421
    | Mm_RefseqProtein = XP_001001421
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 39178942
    | Mm_GenLoc_end = 39240067
    | Mm_Uniprot =  
  }}
}}
'''Cytochrome P450, family 2, subfamily C, polypeptide 8''', also known as '''CYP2C8''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.<ref>{{cite web | title = Entrez Gene: CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1558| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Goldstein JA, de Morais SM |title=Biochemistry and molecular biology of the human CYP2C subfamily. |journal=Pharmacogenetics |volume=4 |issue= 6 |pages= 285-99 |year= 1995 |pmid= 7704034 |doi=  }}
*{{cite journal  | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi=  }}
*{{cite journal  | author=García-Martín E, Martínez C, Ladero JM, Agúndez JA |title=Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals. |journal=Molecular diagnosis & therapy |volume=10 |issue= 1 |pages= 29-40 |year= 2007 |pmid= 16646575 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] DAB2

  • INFO: Beginning work on DAB2... {November 9, 2007 12:41:15 AM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_DAB2_image.jpg {November 9, 2007 12:42:41 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:42:55 AM PST}
  • CREATED: Created new protein page: DAB2 {November 9, 2007 12:43:01 AM PST}

[edit] DTNBP1

  • INFO: Beginning work on DTNBP1... {November 9, 2007 1:01:50 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:02:24 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Dystrobrevin binding protein 1
 | HGNCid = 17328
 | Symbol = DTNBP1
 | AltSymbols =; DBND; DKFZP564K192; FLJ30031; HPS7; MGC20210; My031; SDY
 | OMIM = 607145
 | ECnumber =  
 | Homologene = 12037
 | MGIid = 2137586
 | Function = {{GNF_GO|id=GO:0042802 |text = identical protein binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016528 |text = sarcoplasm}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0042383 |text = sarcolemma}} 
 | Process = {{GNF_GO|id=GO:0006996 |text = organelle organization and biogenesis}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84062
    | Hs_Ensembl = ENSG00000047579
    | Hs_RefseqProtein = NP_115498
    | Hs_RefseqmRNA = NM_032122
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 15631020
    | Hs_GenLoc_end = 15771268
    | Hs_Uniprot = Q96EV8
    | Mm_EntrezGene = 94245
    | Mm_Ensembl = ENSMUSG00000057531
    | Mm_RefseqmRNA = NM_025772
    | Mm_RefseqProtein = NP_080048
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 44933057
    | Mm_GenLoc_end = 45013112
    | Mm_Uniprot = Q91WZ8
  }}
}}
'''Dystrobrevin binding protein 1''', also known as '''DTNBP1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene.<ref>{{cite web | title = Entrez Gene: DTNBP1 dystrobrevin binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84062| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Huizing M, Boissy RE, Gahl WA |title=Hermansky-Pudlak syndrome: vesicle formation from yeast to man. |journal=Pigment Cell Res. |volume=15 |issue= 6 |pages= 405-19 |year= 2003 |pmid= 12453182 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] DYNLL1

  • INFO: Beginning work on DYNLL1... {November 9, 2007 12:51:46 AM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_DYNLL1_image.jpg {November 9, 2007 12:52:16 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:52:42 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_DYNLL1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cmi.
 | PDB = {{PDB2|1cmi}}, {{PDB2|1f3c}}, {{PDB2|1f95}}, {{PDB2|1f96}}, {{PDB2|1pwj}}, {{PDB2|1pwk}}, {{PDB2|1re6}}, {{PDB2|1rhw}}, {{PDB2|2pg1}}
 | Name = Dynein, light chain, LC8-type 1
 | HGNCid = 15476
 | Symbol = DYNLL1
 | AltSymbols =; DLC1; DLC8; DNCL1; DNCLC1; LC8; LC8a; MGC126137; MGC126138; PIN; hdlc1
 | OMIM = 601562
 | ECnumber =  
 | Homologene = 37844
 | MGIid = 1861457
 | GeneAtlas_image1 = PBB_GE_DYNLL1_200703_at_tn.png
 | Function = {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005868 |text = cytoplasmic dynein complex}} {{GNF_GO|id=GO:0005874 |text = microtubule}} 
 | Process = {{GNF_GO|id=GO:0007017 |text = microtubule-based process}} {{GNF_GO|id=GO:0007292 |text = female gamete generation}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8655
    | Hs_Ensembl = ENSG00000088986
    | Hs_RefseqProtein = NP_001032583
    | Hs_RefseqmRNA = NM_001037494
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 119418309
    | Hs_GenLoc_end = 119420679
    | Hs_Uniprot = P63167
    | Mm_EntrezGene = 56455
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = NM_019682
    | Mm_RefseqProtein = NP_062656
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Dynein, light chain, LC8-type 1''', also known as '''DYNLL1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.<ref>{{cite web | title = Entrez Gene: DYNLL1 dynein, light chain, LC8-type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8655| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}

[edit] DYRK1A

  • INFO: Beginning work on DYRK1A... {November 9, 2007 12:43:01 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:44:39 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
 | HGNCid = 3091
 | Symbol = DYRK1A
 | AltSymbols =; DYRK; DYRK1; HP86; MNB; MNBH
 | OMIM = 600855
 | ECnumber =  
 | Homologene = 55576
 | MGIid = 1330299
 | GeneAtlas_image1 = PBB_GE_DYRK1A_211079_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_DYRK1A_209033_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_DYRK1A_211541_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0043621 |text = protein self-association}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016607 |text = nuclear speck}} 
 | Process = {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0018108 |text = peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1859
    | Hs_Ensembl = ENSG00000157540
    | Hs_RefseqProtein = NP_001387
    | Hs_RefseqmRNA = NM_001396
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 37713077
    | Hs_GenLoc_end = 37809347
    | Hs_Uniprot = Q13627
    | Mm_EntrezGene = 13548
    | Mm_Ensembl = ENSMUSG00000022897
    | Mm_RefseqmRNA = NM_007890
    | Mm_RefseqProtein = NP_031916
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 94720258
    | Mm_GenLoc_end = 94801197
    | Mm_Uniprot = Q61158
  }}
}}
'''Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A''', also known as '''DYRK1A''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.<ref>{{cite web | title = Entrez Gene: DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1859| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Hämmerle B, Elizalde C, Galceran J, ''et al.'' |title=The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implications. |journal=J. Neural Transm. Suppl. |volume= |issue= 67 |pages= 129-37 |year= 2004 |pmid= 15068245 |doi=  }}
*{{cite journal  | author=Galceran J, de Graaf K, Tejedor FJ, Becker W |title=The MNB/DYRK1A protein kinase: genetic and biochemical properties. |journal=J. Neural Transm. Suppl. |volume= |issue= 67 |pages= 139-48 |year= 2004 |pmid= 15068246 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] EBAG9

  • INFO: Beginning work on EBAG9... {November 9, 2007 12:55:50 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:56:44 AM PST}
  • CREATED: Created new protein page: EBAG9 {November 9, 2007 12:56:51 AM PST}

[edit] FCER1A

  • INFO: Beginning work on FCER1A... {November 9, 2007 12:44:40 AM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_FCER1A_image.jpg {November 9, 2007 12:45:11 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:45:22 AM PST}
  • CREATED: Created new protein page: FCER1A {November 9, 2007 12:45:30 AM PST}

[edit] GABRG2

  • INFO: Beginning work on GABRG2... {November 9, 2007 12:45:30 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:46:07 AM PST}
  • CREATED: Created new protein page: GABRG2 {November 9, 2007 12:46:15 AM PST}

[edit] GATA2

  • INFO: Beginning work on GATA2... {November 9, 2007 12:46:15 AM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_GATA2_image.jpg {November 9, 2007 12:47:09 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:47:21 AM PST}
  • CREATED: Created new protein page: GATA2 {November 9, 2007 12:47:28 AM PST}

[edit] GNA11

  • INFO: Beginning work on GNA11... {November 9, 2007 12:47:28 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:48:39 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
 | HGNCid = 4379
 | Symbol = GNA11
 | AltSymbols =; GNA-11
 | OMIM = 139313
 | ECnumber =  
 | Homologene = 20474
 | MGIid = 95766
 | GeneAtlas_image1 = PBB_GE_GNA11_564_at_tn.png
 | GeneAtlas_image2 = PBB_GE_GNA11_40562_at_tn.png
 | GeneAtlas_image3 = PBB_GE_GNA11_204248_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003774 |text = motor activity}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016459 |text = myosin complex}} 
 | Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001508 |text = regulation of action potential}} {{GNF_GO|id=GO:0006471 |text = protein amino acid ADP-ribosylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0045634 |text = regulation of melanocyte differentiation}} {{GNF_GO|id=GO:0048066 |text = pigmentation during development}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2767
    | Hs_Ensembl = ENSG00000088256
    | Hs_RefseqProtein = NP_002058
    | Hs_RefseqmRNA = NM_002067
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 3045408
    | Hs_GenLoc_end = 3072452
    | Hs_Uniprot = P29992
    | Mm_EntrezGene = 14672
    | Mm_Ensembl = ENSMUSG00000034781
    | Mm_RefseqmRNA = NM_010301
    | Mm_RefseqProtein = NP_034431
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 80931861
    | Mm_GenLoc_end = 80948175
    | Mm_Uniprot = Q3UPA1
  }}
}}
'''Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)''', also known as '''GNA11''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Wilkie TM, Gilbert DJ, Olsen AS, ''et al.'' |title=Evolution of the mammalian G protein alpha subunit multigene family. |journal=Nat. Genet. |volume=1 |issue= 2 |pages= 85-91 |year= 1993 |pmid= 1302014 |doi= 10.1038/ng0592-85 }}
*{{cite journal  | author=Raymond JR, Mukhin YV, Gelasco A, ''et al.'' |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2-3 |pages= 179-212 |year= 2002 |pmid= 11916537 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] ISG15

  • INFO: Beginning work on ISG15... {November 9, 2007 1:00:04 AM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_ISG15_image.jpg {November 9, 2007 1:00:41 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 1:00:54 AM PST}
  • CREATED: Created new protein page: ISG15 {November 9, 2007 1:01:01 AM PST}

[edit] MAPK8IP1

  • INFO: Beginning work on MAPK8IP1... {November 9, 2007 12:56:51 AM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_MAPK8IP1_image.jpg {November 9, 2007 12:57:46 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:58:04 AM PST}
  • CREATED: Created new protein page: MAPK8IP1 {November 9, 2007 12:58:11 AM PST}

[edit] PTGES

  • INFO: Beginning work on PTGES... {November 9, 2007 12:58:56 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:00:04 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Prostaglandin E synthase
 | HGNCid = 9599
 | Symbol = PTGES
 | AltSymbols =; MGC10317; MGST-IV; MGST1-L1; MGST1L1; PGES; PIG12; PP102; PP1294; TP53I12
 | OMIM = 605172
 | ECnumber =  
 | Homologene = 3587
 | MGIid = 1927593
 | GeneAtlas_image1 = PBB_GE_PTGES_210367_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_PTGES_207388_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0016853 |text = isomerase activity}} {{GNF_GO|id=GO:0050220 |text = prostaglandin-E synthase activity}} 
 | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005641 |text = nuclear envelope lumen}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006693 |text = prostaglandin metabolic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9536
    | Hs_Ensembl = ENSG00000148344
    | Hs_RefseqProtein = NP_004869
    | Hs_RefseqmRNA = NM_004878
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 131540433
    | Hs_GenLoc_end = 131555165
    | Hs_Uniprot = O14684
    | Mm_EntrezGene = 64292
    | Mm_Ensembl = ENSMUSG00000050737
    | Mm_RefseqmRNA = NM_022415
    | Mm_RefseqProtein = NP_071860
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 30711480
    | Mm_GenLoc_end = 30725306
    | Mm_Uniprot = Q3UDM3
  }}
}}
'''Prostaglandin E synthase''', also known as '''PTGES''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.<ref>{{cite web | title = Entrez Gene: PTGES prostaglandin E synthase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9536| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}

[edit] RIPK2

  • INFO: Beginning work on RIPK2... {November 9, 2007 12:52:42 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:53:40 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Receptor-interacting serine-threonine kinase 2
 | HGNCid = 10020
 | Symbol = RIPK2
 | AltSymbols =; CCK; CARD3; CARDIAK; GIG30; RICK; RIP2
 | OMIM = 603455
 | ECnumber =  
 | Homologene = 37856
 | MGIid = 1891456
 | GeneAtlas_image1 = PBB_GE_RIPK2_209544_at_tn.png
 | GeneAtlas_image2 = PBB_GE_RIPK2_209545_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030274 |text = LIM domain binding}} {{GNF_GO|id=GO:0050700 |text = CARD domain binding}} 
 | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} 
 | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8767
    | Hs_Ensembl = ENSG00000104312
    | Hs_RefseqProtein = NP_003812
    | Hs_RefseqmRNA = NM_003821
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 90839173
    | Hs_GenLoc_end = 90872432
    | Hs_Uniprot = O43353
    | Mm_EntrezGene = 192656
    | Mm_Ensembl = ENSMUSG00000041135
    | Mm_RefseqmRNA = NM_138952
    | Mm_RefseqProtein = NP_620402
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 16049889
    | Mm_GenLoc_end = 16090790
    | Mm_Uniprot = A1A4B5
  }}
}}
'''Receptor-interacting serine-threonine kinase 2''', also known as '''RIPK2''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.<ref>{{cite web | title = Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8767| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Medzhitov R, Janeway C |title=Innate immune recognition: mechanisms and pathways. |journal=Immunol. Rev. |volume=173 |issue=  |pages= 89-97 |year= 2000 |pmid= 10719670 |doi=  }}
*{{cite journal  | author=Dufner A, Mak TW |title=CARD tricks: controlling the interactions of CARD6 with RICK and microtubules. |journal=Cell Cycle |volume=5 |issue= 8 |pages= 797-800 |year= 2006 |pmid= 16582588 |doi=  }}
}}
{{refend}}

{{protein-stub}}

[edit] SNAP23

  • INFO: Beginning work on SNAP23... {November 9, 2007 12:53:40 AM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_SNAP23_image.jpg {November 9, 2007 12:54:52 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:55:06 AM PST}
  • CREATED: Created new protein page: SNAP23 {November 9, 2007 12:55:14 AM PST}

[edit] UBTF

  • INFO: Beginning work on UBTF... {November 9, 2007 12:48:39 AM PST}
  • UPLOAD: Added new Image to wiki: Image:PBB_Protein_UBTF_image.jpg {November 9, 2007 12:49:36 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 12:49:47 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_UBTF_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k99.
 | PDB = {{PDB2|1k99}}, {{PDB2|1l8y}}, {{PDB2|1l8z}}, {{PDB2|1v63}}, {{PDB2|1v64}}, {{PDB2|1wgf}}
 | Name = Upstream binding transcription factor, RNA polymerase I
 | HGNCid = 12511
 | Symbol = UBTF
 | AltSymbols =; NOR-90; UBF
 | OMIM = 600673
 | ECnumber =  
 | Homologene = 7970
 | MGIid = 98512
 | GeneAtlas_image1 = PBB_GE_UBTF_202692_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_UBTF_214881_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003701 |text = RNA polymerase I transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} 
 | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006356 |text = regulation of transcription from RNA polymerase I promoter}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7343
    | Hs_Ensembl = ENSG00000108312
    | Hs_RefseqProtein = NP_001070151
    | Hs_RefseqmRNA = NM_001076683
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 39637928
    | Hs_GenLoc_end = 39653762
    | Hs_Uniprot = P17480
    | Mm_EntrezGene = 21429
    | Mm_Ensembl = ENSMUSG00000020923
    | Mm_RefseqmRNA = NM_001044383
    | Mm_RefseqProtein = NP_001037848
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 102122082
    | Mm_GenLoc_end = 102135080
    | Mm_Uniprot = Q05DS1
  }}
}}
'''Upstream binding transcription factor, RNA polymerase I''', also known as '''UBTF''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7343| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}

[edit] XBP1

  • INFO: Beginning work on XBP1... {November 9, 2007 12:49:47 AM PST}
  • CREATE: Found no pages, creating new page. {November 9, 2007 12:50:22 AM PST}
  • CREATED: Created new protein page: XBP1 {November 9, 2007 12:50:30 AM PST}

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