SNAP23

From Wikipedia, the free encyclopedia

Synaptosomal-associated protein, 23kDa

PDB rendering based on 1nhl.

Available structures: 1nhl

Identifiers

Symbol(s)

SNAP23; HsT17016; SNAP23A; SNAP23B

External IDs

OMIM: 602534 MGI: 109356 HomoloGene: 37857

Gene ontology
Molecular Function:	• SNAP receptor activity • protein binding
Cellular Component:	• plasma membrane • synaptosome • synapse
Biological Process:	• post-Golgi vesicle-mediated transport • vesicle targeting • membrane fusion • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003825 (mRNA)
NP_003816 (protein)

NM_009222 (mRNA)
NP_033248 (protein)

Location

Chr 15: 40.58 - 40.61 Mb

Chr 2: 120.26 - 120.29 Mb

Pubmed search

[1]

[2]

Synaptosomal-associated protein, 23kDa, also known as SNAP23, is a human gene.

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.^[1]

[edit] References

^ Entrez Gene: SNAP23 synaptosomal-associated protein, 23kDa.

[edit] Further reading

Ravichandran V, Chawla A, Roche PA (1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues.". J. Biol. Chem. 271 (23): 13300–3. PMID 8663154.
Mollinedo F, Lazo PA (1997). "Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells.". Biochem. Biophys. Res. Commun. 231 (3): 808–12. doi:10.1006/bbrc.1997.6196. PMID 9070898.
Araki S, Tamori Y, Kawanishi M, et al. (1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c.". Biochem. Biophys. Res. Commun. 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. PMID 9168999.
Tang BL, Tan AE, Lim LK, et al. (1998). "Syntaxin 12, a member of the syntaxin family localized to the endosome.". J. Biol. Chem. 273 (12): 6944–50. PMID 9507000.
Galli T, Zahraoui A, Vaidyanathan VV, et al. (1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells.". Mol. Biol. Cell 9 (6): 1437–48. PMID 9614185.
Foster LJ, Yeung B, Mohtashami M, et al. (1998). "Binary interactions of the SNARE proteins syntaxin-4, SNAP23, and VAMP-2 and their regulation by phosphorylation.". Biochemistry 37 (31): 11089–96. doi:10.1021/bi980253t. PMID 9693005.
Riento K, Galli T, Jansson S, et al. (1999). "Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells.". J. Cell. Sci. 111 ( Pt 17): 2681–8. PMID 9701566.
Guo Z, Turner C, Castle D (1998). "Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells.". Cell 94 (4): 537–48. PMID 9727496.
Inoue T, Nielsen S, Mandon B, et al. (1998). "SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles.". Am. J. Physiol. 275 (5 Pt 2): F752–60. PMID 9815132.
Valdez AC, Cabaniols JP, Brown MJ, Roche PA (1999). "Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network.". J. Cell. Sci. 112 ( Pt 6): 845–54. PMID 10036234.
Okamoto M, Schoch S, Südhof TC (1999). "EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?". J. Biol. Chem. 274 (26): 18446–54. PMID 10373452.
Cabaniols JP, Ravichandran V, Roche PA (2000). "Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly.". Mol. Biol. Cell 10 (12): 4033–41. PMID 10588641.
Kawanishi M, Tamori Y, Okazawa H, et al. (2000). "Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2.". J. Biol. Chem. 275 (11): 8240–7. PMID 10713150.
Paumet F, Le Mao J, Martin S, et al. (2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment.". J. Immunol. 164 (11): 5850–7. PMID 10820264.
Scales SJ, Chen YA, Yoo BY, et al. (2000). "SNAREs contribute to the specificity of membrane fusion.". Neuron 26 (2): 457–64. PMID 10839363.
Martín-Martín B, Nabokina SM, Blasi J, et al. (2000). "Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis.". Blood 96 (7): 2574–83. PMID 11001914.
Faigle W, Colucci-Guyon E, Louvard D, et al. (2000). "Vimentin filaments in fibroblasts are a reservoir for SNAP23, a component of the membrane fusion machinery.". Mol. Biol. Cell 11 (10): 3485–94. PMID 11029050.
Lazo PA, Nadal M, Ferrer M, et al. (2001). "Genomic organization, chromosomal localization, alternative splicing, and isoforms of the human synaptosome-associated protein-23 gene implicated in vesicle-membrane fusion processes.". Hum. Genet. 108 (3): 211–5. PMID 11354632.
Shukla A, Corydon TJ, Nielsen S, et al. (2001). "Identification of three new splice variants of the SNARE protein SNAP-23.". Biochem. Biophys. Res. Commun. 285 (2): 320–7. doi:10.1006/bbrc.2001.5144. PMID 11444845.
Logan MR, Lacy P, Bablitz B, Moqbel R (2002). "Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis.". J. Allergy Clin. Immunol. 109 (2): 299–306. PMID 11842301.