MAPK8IP1

From Wikipedia, the free encyclopedia

Mitogen-activated protein kinase 8 interacting protein 1

PDB rendering based on 2fpd.

Available structures: 2fpd, 2fpe, 2fpf

Identifiers

Symbol(s)

MAPK8IP1; IB1; JIP-1; JIP1; PRKM8IP

External IDs

OMIM: 604641 MGI: 1309464 HomoloGene: 31314

Gene ontology
Molecular Function:	• protein kinase inhibitor activity • MAP-kinase scaffold activity • protein binding • kinase activity • kinesin binding • protein kinase binding
Cellular Component:	• cytoplasm
Biological Process:	• vesicle-mediated transport • regulation of JNK cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005456 (mRNA)
NP_005447 (protein)

NM_011162 (mRNA)
NP_035292 (protein)

Location

Chr 11: 45.86 - 45.88 Mb

Chr 2: 92.18 - 92.2 Mb

Pubmed search

[1]

[2]

Mitogen-activated protein kinase 8 interacting protein 1, also known as MAPK8IP1, is a human gene.

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.^[1]

[edit] References

^ Entrez Gene: MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Dickens M, Rogers JS, Cavanagh J, et al. (1997). "A cytoplasmic inhibitor of the JNK signal transduction pathway.". Science 277 (5326): 693–6. PMID 9235893.
Bonny C, Nicod P, Waeber G (1998). "IB1, a JIP-1-related nuclear protein present in insulin-secreting cells.". J. Biol. Chem. 273 (4): 1843–6. PMID 9442013.
Whitmarsh AJ, Cavanagh J, Tournier C, et al. (1998). "A mammalian scaffold complex that selectively mediates MAP kinase activation.". Science 281 (5383): 1671–4. PMID 9733513.
Mooser V, Maillard A, Bonny C, et al. (1999). "Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene.". Genomics 55 (2): 202–8. doi:10.1006/geno.1998.5641. PMID 9933567.
Yasuda J, Whitmarsh AJ, Cavanagh J, et al. (2000). "The JIP group of mitogen-activated protein kinase scaffold proteins.". Mol. Cell. Biol. 19 (10): 7245–54. PMID 10490659.
Meyer D, Liu A, Margolis B (2000). "Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons.". J. Biol. Chem. 274 (49): 35113–8. PMID 10574993.
Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.". Mol. Cell. Biol. 20 (3): 1030–43. PMID 10629060.
Waeber G, Delplanque J, Bonny C, et al. (2000). "The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes.". Nat. Genet. 24 (3): 291–5. doi:10.1038/73523. PMID 10700186.
Bonny C, Oberson A, Steinmann M, et al. (2000). "IB1 reduces cytokine-induced apoptosis of insulin-secreting cells.". J. Biol. Chem. 275 (22): 16466–72. doi:10.1074/jbc.M908297199. PMID 10748095.
Gotthardt M, Trommsdorff M, Nevitt MF, et al. (2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.". J. Biol. Chem. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
Bonny C, Oberson A, Negri S, et al. (2001). "Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death.". Diabetes 50 (1): 77–82. PMID 11147798.
Verhey KJ, Meyer D, Deehan R, et al. (2001). "Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules.". J. Cell Biol. 152 (5): 959–70. PMID 11238452.
Matsuda S, Yasukawa T, Homma Y, et al. (2001). "c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK.". J. Neurosci. 21 (17): 6597–607. PMID 11517249.
Abderrahmani A, Steinmann M, Plaisance V, et al. (2001). "The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1).". Mol. Cell. Biol. 21 (21): 7256–67. doi:10.1128/MCB.21.21.7256-7267.2001. PMID 11585908.
Cai Y, Lechner MS, Nihalani D, et al. (2002). "Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation.". J. Biol. Chem. 277 (2): 1217–22. doi:10.1074/jbc.M109663200. PMID 11700324.
Scheinfeld MH, Roncarati R, Vito P, et al. (2002). "Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).". J. Biol. Chem. 277 (5): 3767–75. doi:10.1074/jbc.M108357200. PMID 11724784.
Ikeda A, Hasegawa K, Masaki M, et al. (2002). "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway.". J. Biochem. 130 (6): 773–81. PMID 11726277.
Hashimoto M, Hsu LJ, Rockenstein E, et al. (2002). "alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells.". J. Biol. Chem. 277 (13): 11465–72. doi:10.1074/jbc.M111428200. PMID 11790792.