Phenprocoumon

From Wikipedia, the free encyclopedia


Phenprocoumon
Systematic (IUPAC) name
2-hydroxy-3-(1-phenylpropyl)chromen-4-one
Identifiers
CAS number	435-97-2
ATC code	B01AA04
PubChem	9908
DrugBank	APRD00228
Chemical data
Formula	C₁₈H₁₆O₃
Mol. mass	280.318 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	99%
Metabolism	hepatic to inactive metabolites
Half life	5 to 6 days
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is an anticoagulant drug, a derivative of coumarin. It is a vitamin K antagonist that inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders (thrombosis/pulmonary embolism).

[edit] External links

DDB 29943

v • d • e Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Vitamin K antagonists	Acenocoumarol • Clorindione • Coumatetralyl • Dicumarol (Dicoumarol) • Diphenadione • Ethyl biscoumacetate • Phenprocoumon • Phenindione • Tioclomarol • Warfarin

Heparin group	Antithrombin III • Danaparoid • Heparin • Sulodexide • low molecular weight heparin (Bemiparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin)

Glycoprotein IIb/IIIa inhibitors	Abciximab • Eptifibatide • Tirofiban

Other platelet aggregation inhibitors	Acetylsalicylic acid/Aspirin • Aloxiprin • Ditazole • Carbasalate calcium • Cloricromen • Dipyridamole • Indobufen • Picotamide • Triflusal • ADP receptor inhibitors (Clopidogrel, Ticlopidine, Prasugrel) • prostaglandin analogue (Beraprost, Prostacyclin, Iloprost, Treprostinil)

Enzymes	plasminogen activators (Alteplase/Reteplase/Tenecteplase, Streptokinase, Urokinase/Saruplase, Anistreplase) • other serine endopeptidases (Ancrod, Drotrecogin alfa/Protein C, Fibrinolysin) • Brinase

Direct thrombin inhibitors	Argatroban • Bivalirudin • Dabigatran • Desirudin • Hirudin • Lepirudin • Melagatran • Ximelagatran

Other antithrombotics	Apixaban • Defibrotide • Dermatan sulfate • Fondaparinux • Idraparinux • Otamixaban • Rivaroxaban

Non-medicinal	Citrate • EDTA • Oxalate