Lepirudin

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Image:Lepirudin.png
Lepirudin
Systematic (IUPAC) name
?
Identifiers
CAS number	120993-53-5
ATC code	B01AE02
PubChem	?
DrugBank	BTD00024
Chemical data
Formula	C288H448N80O110S6
Mol. mass	6983.5 g/mol
Pharmacokinetic data
Bioavailability	100%
Metabolism	?
Half life	~1.3 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	B(US)
Legal status
Routes	SQ or IV

Lepirudin (Refludan ) is an anticoagulant which functions as a direct thrombin inhibitor.

It is derived from the saliva of the medicinal leech Hirudo medicinalis.

Lepirudin may be used as a medication in Heparin-induced thrombocytopenia.

[edit] External links

• Hirudo Medicinalis TURKEY, Supplier of Hirudo Medicinalis
• [http://www.tibbisuluk.com Hirudo Medicinalis TURKEY,
• DDB 30082
• Smythe M, Stephens J, Koerber J, Mattson J (2005). "A comparison of lepirudin and argatroban outcomes.". Clin Appl Thromb Hemost 11 (4): 371–4. doi:10.1177/107602960501100403. PMID 16244762. 
• "Predictive factors for thrombosis and major bleeding in an observational study in 181 patients with heparin-induced thrombocytopenia treated with lepirudin." . Blood. PMID 16690967. 
• Lubenow N, Eichler P, Lietz T, Greinacher A (2005). "Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3.". J Thromb Haemost 3 (11): 2428–36. doi:10.1111/j.1538-7836.2005.01623.x. PMID 16241940. 
• http://www.refludan.com/product/index.htm

v • d • e Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01) Vitamin K antagonists Acenocoumarol • Clorindione • Coumatetralyl • Dicumarol (Dicoumarol) • Diphenadione • Ethyl biscoumacetate • Phenprocoumon • Phenindione • Tioclomarol • Warfarin Heparin group Antithrombin III • Danaparoid • Heparin • Sulodexide • low molecular weight heparin (Bemiparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin) Glycoprotein IIb/IIIa inhibitors Abciximab • Eptifibatide • Tirofiban Other platelet aggregation inhibitors Acetylsalicylic acid/Aspirin • Aloxiprin • Ditazole • Carbasalate calcium • Cloricromen • Dipyridamole • Indobufen • Picotamide • Triflusal • ADP receptor inhibitors (Clopidogrel, Ticlopidine, Prasugrel) • prostaglandin analogue (Beraprost, Prostacyclin, Iloprost, Treprostinil) Enzymes plasminogen activators (Alteplase/Reteplase/Tenecteplase, Streptokinase, Urokinase/Saruplase, Anistreplase) • other serine endopeptidases (Ancrod, Drotrecogin alfa/Protein C, Fibrinolysin) • Brinase Direct thrombin inhibitors Argatroban • Bivalirudin • Dabigatran • Desirudin • Hirudin • Lepirudin • Melagatran • Ximelagatran Other antithrombotics Apixaban • Defibrotide • Dermatan sulfate • Fondaparinux • Idraparinux • Otamixaban • Rivaroxaban Non-medicinal Citrate • EDTA • Oxalate