O-6-methylguanine-DNA methyltransferase

From Wikipedia, the free encyclopedia

PDB rendering based on 1eh6.

Available structures: 1eh6, 1eh7, 1eh8, 1qnt, 1t38, 1t39, 1yfh

Identifiers

Symbol(s)

MGMT;

External IDs

OMIM: 156569 MGI: 96977 HomoloGene: 31089

Gene ontology
Molecular Function:	• DNA binding • methylated-DNA-[protein-cysteine S-methyltransferase activity] • zinc ion binding • DNA-methyltransferase activity • transferase activity • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• DNA ligation • DNA dealkylation • regulation of caspase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002412 (mRNA)
NP_002403 (protein)

NM_008598 (mRNA)
NP_032624 (protein)

Location

Chr 10: 131.16 - 131.46 Mb

Chr 7: 136.73 - 136.97 Mb

Pubmed search

[1]

[2]

O-6-methylguanine-DNA methyltransferase, also known as MGMT, is a human gene. Methylation of the gene's promotor may play a significant role in carcinogenesis.

A 2005 study has showed that in patients with glioblastoma multiforme, a severe type of brain tumor, the methylation state of the MGMT gene determined whether the disease would be responsive to temozolomide; if the promotor was methylated temozolomide was effective.^[1]

[edit] References

^ Hegi ME, Diserens AC, Gorlia T, et al (2005). "MGMT gene silencing and benefit from temozolomide in glioblastoma". N. Engl. J. Med. 352 (10): 997–1003. doi:10.1056/NEJMoa043331. PMID 15758010.

[edit] See also

[edit] Further reading

Margison GP, Povey AC, Kaina B, Santibáñez Koref MF (2003). "Variability and regulation of O6-alkylguanine-DNA alkyltransferase.". Carcinogenesis 24 (4): 625–35. PMID 12727789.

v • d • e Transferase: one carbon transferases (EC 2.1)

2.1.1 - Methyltransferases	N-methyltransferase: Histamine N-methyltransferase - Phenylethanolamine N-methyltransferase - Tryptamine N-methyltransferase - Phosphatidylethanolamine N-methyltransferase O-methyltransferase: 5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase - Catechol-O-methyl transferase homocysteine methyltransferase: Betaine-homocysteine methyltransferase - Homocysteine methyltransferase - 5-Methyltetrahydrofolate-homocysteine methyltransferase Other: Phosphatidyl ethanolamine methyltransferase - DNMT3B - Histone methyltransferase - Thymidylate synthase - DNA methyltransferase

2.1.2 - Hydroxy methyl-, Formyl- and Related Transferases	Serine hydroxymethyltransferase - Phosphoribosylglycinamide formyltransferase - Inosine monophosphate synthase - Glutamate formimidoyltransferase - Aminomethyltransferase

2.1.3 - Carboxy- and Carbamoyl transferases	Ornithine transcarbamylase

2.1.4 - Amidino transferases	Arginine:glycine amidinotransferase