Naratriptan

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Naratriptan
Systematic (IUPAC) name
N-methyl-2-[3-(1-methyl-4-piperidyl )-1H-indol-5-yl]-ethanesulfonamide
Identifiers
CAS number	121679-13-8
ATC code	N02CC02
PubChem	4440
DrugBank	APRD00220
Chemical data
Formula	C17H25N3O2S
Mol. mass	335.465 g/mol
Pharmacokinetic data
Bioavailability	74%
Metabolism	Hepatic
Half life	5-8 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	B3(AU) C(US)
Legal status	℞ Prescription only
Routes	Oral

Naratriptan (trade name Amerge) is a triptan drug developed by Glaxo Wellcome Inc. and is used for the treatment of migraine headaches. Naratriptan is available in 2.5 mg tablets. It is a selective 5-hydroxytryptamine1 receptor subtype agonist. Naratriptan hydrochloride is chemically designated as N-methyl-3-( 1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide.

Some side effects of the drug include vision changes, tingling sensations, tiredness or weakness, upset stomach, dizziness, and warm/cold temperature sensations. The U.S. Food and Drug Administration (FDA) approved naratriptan on February 11, 1998.

[edit] Side effects

Side effects include: dizziness, drowsiness, tingling of the hands or feet, unusual tiredness, nausea, dry mouth and unsteadiness. If these effects persist or worsen, notify your doctor promptly. Side-effects which are unlikely and which should be promptly reported include: chest pain/pressure, throat pain/pressure, unusually fast/slow/irregular pulse, one-sided muscle weakness, vision problems, cold/bluish hands or feet, stomach pain, bloody diarrhea, mental/mood changes, and fainting. In the unlikely event you have a serious allergic reaction to this drug, seek immediate medical attention. Symptoms of a serious allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing.

v • d • e Antimigraine preparations (N02C) Ergot alkaloids Dihydroergotamine • Ergotamine • Methysergide • Lisuride Corticosteroid derivatives Flumedroxone Selective serotonin (5-HT1) agonists Triptans (Almotriptan, Eletriptan, Frovatriptan, Naratriptan, Rizatriptan, Sumatriptan, Zolmitriptan) Other antimigraine preparations Pizotifen • Clonidine • Topiramate • Amidrine • Iprazochrome • Dimetotiazine • Oxetorone

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