Almotriptan
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Almotriptan
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| Systematic (IUPAC) name | |
| N,N-dimethyl-2- [5-(pyrrolidin-1-ylsulfonylmethyl)- 1H-indol-3-yl]-ethanamine | |
| Identifiers | |
| CAS number | |
| ATC code | N02 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C17H25N3O2S |
| Mol. mass | 335.465 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 70% |
| Protein binding | 35% |
| Metabolism | ? |
| Half life | 3-4 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
C(USA) |
| Legal status | |
| Routes | Oral |
Almotriptan (Axert®, Almogran®) is a triptan drug discovered by Almirall Prodesfarma and licensed to Ortho-McNeil for the treatment of migraine headaches. It is available in strengths of 6.25 and 12.5 mg as a tablet.
In the United States and Canada almotriptan is available under the name Axert® only by prescription. AXERT® for oral administration contains almotriptan malate equivalent to 6.25 or 12.5 mg of almotriptan. Each compressed tablet contains the following inactive ingredients: mannitol, cellulose, povidone, sodium starch glycolate, sodium stearyl fumarate, titanium dioxide, hypromellose, polyethylene glycol, propylene glycol, iron oxide (6.25 mg only), FD&C Blue No. 2 (12.5 mg only), and carnauba wax. The brand Almogran is used in Belgium, Finland, France, Germany, Italy, Portugal, Spain and the United Kingdom. Each 12.5 mg. tablet contains the following inactive ingredients: carnauba wax, hypromellose, indigo carmine (E132), macrogol 400, mannitol, microcrystalline cellulose, povidone, propylene glycol, sodium starch glycollate, sodium stearyl fumarate and titanium dioxide (E171).
[edit] Clinical uses
Almotriptan is indicated for the acute treatment of migraine with or without aura in adults.
[edit] External links
- R&D page by Almirall Prodesfarma
- Axert Official homepage by Ortho-McNeil
- Axert prescribing information
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