Microscopic polyangiitis

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Microscopic polyangiitis Classification and external resources
ICD-10	M31.7
DiseasesDB	8193
eMedicine	med/2931

Microscopic polyangiitis (MPA) is an ill-defined autoimmune disease characterized by pauci-immune, necrotizing, small-vessel vasculitis without clinical or pathological evidence of necrotizing granulomatous inflammation. Because many different organ systems may be involved, a wide range of symptoms are possible in MPA.

Contents 1 Diagnosis 2 Cause 3 Treatment 4 See also 5 External links

[edit] Diagnosis

Laboratory tests show an increased sedimentation rate, reduced red blood count, antineutrophil cytoplasmic antibodies (p-ANCA) directed against MPO(a constituent of neutrophil granules), and protein and red blood cells in the urine.

The test for anti-glomerular basement membrane antibody (GBM), which is positive in Goodpasture's syndrome, is negative.

[edit] Cause

This condition, the clinical picture of which may include many features of systemic lupus erythematosis, has been reported to have been caused by antibiotics and also by certain infections, though, as with many autoimmune diseases, the causes remain to a large extent unknown.

[edit] Treatment

The customary treatment involves long term dosage of prednisone, alternated or combined with cytotoxic drugs, such as cyclophosphamide or azathioprine. Plasmapheresis may also be indicated in the acute setting to remove ANCA antibodies.

[edit] See also

• ANCA-associated vasculitides
• Polyarteritis nodosa

[edit] External links

• Overview at Johns Hopkins

• Overview at Cleveland Clinic

v • d • e Diseases of the musculoskeletal system and connective tissue (M, 710-739) Arthropathies Arthritis (Septic arthritis, Reactive arthritis, Rheumatoid arthritis, Psoriatic arthritis, Felty's syndrome, Juvenile idiopathic arthritis, Still's disease) - crystal (Gout, Chondrocalcinosis) - Osteoarthritis (Heberden's node, Bouchard's nodes) acquired deformities of fingers and toes (Boutonniere deformity, Bunion, Hallux rigidus, Hallux varus, Hammer toe, Swan neck deformity) - other acquired deformities of limbs (Valgus deformity, Varus deformity, Wrist drop, Foot drop, Flat feet, Club foot, Unequal leg length, Winged scapula) patella (Luxating patella, Chondromalacia patellae) Protrusio acetabuli - Hemarthrosis - Arthralgia - Osteophyte Systemic CT disorders vasculitis: Churg-Strauss syndrome - Kawasaki disease - Hypersensitivity vasculitis - Wegener's granulomatosis - Arteritis (Polyarteritis nodosa, Takayasu's arteritis, Temporal arteritis) immune/autoimmune: Goodpasture's syndrome - Microscopic polyangiitis - Systemic lupus erythematosus (Drug-induced) - Dermatomyositis (Juvenile dermatomyositis) - Polymyositis - Scleroderma - Sjögren's syndrome - Behçet's disease - Polymyalgia rheumatica - Eosinophilic fasciitis Hypermobility Dorsopathies spinal curvature (Kyphosis, Lordosis, Scoliosis) - Scheuermann's disease - Spondylolysis - Torticollis - Spondylolisthesis Spondylopathies (Ankylosing spondylitis, Spondylosis, Spinal stenosis) - Schmorl's nodes - Degenerative disc disease - Coccydynia - Back pain (Radiculopathy, Neck pain, Sciatica, Low back pain) Soft tissue disorders muscle: Myositis (Pyomyositis) - Myositis ossificans (Fibrodysplasia ossificans progressiva) synovium and tendon: Synovitis/Tenosynovitis (Calcific tendinitis, Stenosing tenosynovitis, Trigger finger, DeQuervain's syndrome) - Irritable hip - Ganglion cyst bursa: bursitis (Olecranon, Prepatellar, Trochanteric) - Baker's cyst fibroblastic disorders: Dupuytren's contracture - Fasciitis (Plantar fasciitis, Nodular fasciitis, Necrotizing fasciitis) - Fibromatosis shoulder lesions: Adhesive capsulitis - Rotator cuff tear - Subacromial bursitis enthesis: enthesopathies (Iliotibial band syndrome, Achilles tendinitis, Patellar tendinitis, Golfer's elbow, Tennis elbow, Metatarsalgia, Bone spur, Tendinitis) other, NEC: Muscle weakness - Rheumatism - Myalgia - Neuralgia - Neuritis - Panniculitis - Fibromyalgia Osteopathies disorders of bone density and structure: Osteoporosis - Osteomalacia - continuity of bone (Pseudarthrosis, Stress fracture) - Monostotic fibrous dysplasia - Skeletal fluorosis - Aneurysmal bone cyst - Hyperostosis - Osteosclerosis Osteomyelitis - Avascular necrosis - Paget's disease of bone - Algoneurodystrophy - Osteolysis - Infantile cortical hyperostosis Chondropathies Juvenile osteochondrosis (Legg-Calvé-Perthes syndrome, Osgood-Schlatter disease, Köhler disease, Sever's disease) - Osteochondritis - Tietze's syndrome - Relapsing polychondritis See also congenital conditions (Q65-Q79, 754-756)