Lovastatin nonaketide synthase

From Wikipedia, the free encyclopedia

In enzymology, a lovastatin nonaketide synthase (EC 2.3.1.161) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 10 H⁺ + S-adenosyl-L-methionine dihydromonacolin L + 9 CoA + 8 CO₂ + 11 NADP⁺ + S-adenosyl-L-homocysteine + 6 H₂O

The 5 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, H⁺, and S-adenosyl-L-methionine, whereas its 6 products are dihydromonacolin L, CoA, CO₂, NADP⁺, S-adenosyl-L-homocysteine, and H₂O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing).

[edit] References

• IUBMB entry for 2.3.1.161
• BRENDA references for 2.3.1.161 (Recommended.)
• PubMed references for 2.3.1.161
• PubMed Central references for 2.3.1.161
• Google Scholar references for 2.3.1.161
• Heever JP, Hutchinson CR and Vederas JC (2000). "Lovastatin nonaketide synthase catalyses an intramolecular Diels-Alder reaction of a substrate analogue". J. Am. Chem. Soc. 122: 11519–11520. 

[edit] External links

The CAS registry number for this enzyme class is 235426-97-8.

• IUBMB entry for 2.3.1.161

• KEGG entry for 2.3.1.161

• BRENDA entry for 2.3.1.161

• NiceZyme view of 2.3.1.161

• EC2PDB: PDB structures for 2.3.1.161

• PRIAM entry for 2.3.1.161

• PUMA2 entry for 2.3.1.161

• IntEnz: Integrated Enzyme entry for 2.3.1.161

• MetaCyc entry for 2.3.1.161

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050637: lovastatin nonaketide synthase

• AMIGO entry for GO code 0050637: lovastatin nonaketide synthase