Lorcainide

From Wikipedia, the free encyclopedia

Lorcainide
Systematic (IUPAC) name
N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-yl-
4-piperidyl)acetamide
Identifiers
CAS number 59729-31-6
ATC code C01BC07
PubChem 42884
Chemical data
Formula C22H27ClN2O 
Mol. mass 370.915 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 78
Metabolism  ?
Half life 14.3 +/-3.7
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Lorcainide is a class 1c antiarrhythmic agent. It was discovered at Janssen Pharmaceutica in 1968.

[edit] References

  • Kesteloot H, Stroobandt R., Clinical experience with lorcainide (R 15 889), a new anti-arrhythmic drug, Arch Int Pharmacodyn Ther. 1977 Dec;230(2):225-34.
  • Carmeliet E, Janssen PA, Marsboom R, Van Nueten JM, Xhonneux R., Antiarrhythmic, electrophysiologic and hemodynamic effects of lorcainide, Arch Int Pharmacodyn Ther. 1978 Jan;231(1):104-30.


Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Antiarrhythmic agents (C01B)
class I
(sodium channel)
class Ia
class Ib
class Ic
Encainide • Flecainide • Lorcainide • Moricizine • Propafenone
class II
(beta blockers)
class III
(potassium channel)
class IV
(calcium channel blockers)
class V
(other)