Disopyramide

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Disopyramide
Systematic (IUPAC) name
4-dipropan-2-ylamino-2-phenyl-2-pyridin-2-yl-butanamide
Identifiers
CAS number	3737-09-5
ATC code	C01BA03
PubChem	3114
DrugBank	APRD00507
Chemical data
Formula	C21H29N3O
Mol. mass	339.475 g/mol
Pharmacokinetic data
Bioavailability	High
Protein binding	50% to 65% (concentration-dependent)
Metabolism	Hepatic (CYP3A4-mediated)
Half life	6.7 hours (range 4 to 10 hours)
Excretion	Renal (80%)
Therapeutic considerations
Pregnancy cat.	B2(AU) C(US)
Legal status	POM(UK) ℞-only(US)
Routes	Oral, intravenous

Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication. It is a Class Ia antiarrhythmic used in the treatment of ventricular tachycardias. It has no effect on alpha or beta adrenergic receptors. It resembles Quinidine but it has a marked anti-muscarinic effect on the heart, for this reason, it is not considered as a drug of 1st choice. It is also used in ventricular arrhythmia and supraventricular arrhythmia that might follow myocardial infarctions.

[edit] Cardiac Adverse Effects

• Acute heart failure[1]
• Severe hypotension

[edit] Extracardiac Effects

• Dry mouth
• Constipation
• Urinary retention
• Blurred vision
• Glaucoma
• Rash
• Agranulocytosis

[edit] External links

• Disopyramide on RxList

v • d • e Antiarrhythmic agents (C01B) class I (sodium channel) class Ia Ajmaline • Disopyramide • Prajmaline • Procainamide • Quinidine • Sparteine class Ib Aprindine • Lidocaine • Mexiletine • Tocainide class Ic Encainide • Flecainide • Lorcainide • Moricizine • Propafenone class II (beta blockers) Propranolol • Metoprolol • Nadolol • Atenolol • Acebutolol • Pindolol class III (potassium channel) Amiodarone • Bretylium tosylate • Bunaftine • Dofetilide • Ibutilide • Sotalol class IV (calcium channel blockers) Verapamil • Diltiazem class V (other) Adenosine • Atropine • Digoxin