Talk:Lansoprazole

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[edit] Following

Following information from DrugBank should be added: "Mechanism of Action. Lansoprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but rather suppress gastric acid secretion by specific inhibition of the (H+,K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the parietal cell, Lansoprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.

Absorption. The absorption of lansoprazole is rapid, with mean Cmax occurring approximately 1.7 hours after oral dosing, and relatively complete with absolute bioavailability over 80%. Toxicity Symptoms of overdose include abdominal pain, nausea and diarrhea.

Protein binding is approximately 97%

Biotransformation. Hepatic. Two metabolites have been identified in measurable quantities in plasma (the hydroxylated sulfinyl and sulfone derivatives of lansoprazole). These metabolites have very little or no antisecretory activity. Lansoprazole is thought to be transformed into two active species which inhibit acid secretion by (H+,K+)-ATPase within the parietal cell canaliculus, but are not present in the systemic circulation."

[edit] Spelling Changes to technical terms

After getting a prescription for Prevacid, I was pleased to see that Wikipedia had a page, but was confronted with several unfamiliar terms. It made the most sense to make them links, so that I could read the other pages. I'm not completely happy with the Side Effects section - perhaps everything should be a link, even common terms like nausea.

In the course of making the changes, I found several possible misspellings:

http://www.wrongdiagnosis.com/medical-misspelling helped in some cases, but it is possible that I've confused two similar technical terms, since I have no medical training.

Also, bisacodyl and delavirdine are non-existant pages with links to them, so I'm reasonably sure they are spelled correctly. JohnWhitlock 19:15, 21 March 2006 (UTC)

And now, they exist. Wikipedia works. JohnWhitlock 21:58, 10 April 2006 (UTC)

[edit] Changes

This version of the information appears to be more complete than previous. Does it not? —Preceding unsigned comment added by 156.70.222.27 (talk • contribs)

It is, but that is not the point; much of the content you added seems to have been copied word for word from the lansoprazole prescribing information (evidence here). Linking to prescribing information is fine, but "citing" it verbatim is not. Some of the content present in PIs may also make the atricle too technical for the general reader, which runs contrary to the purpose of an encyclopedia, not to mention this proposal. Original content – in your own words – is more than welcome, but meanwhile, I have reverted your edit. Also, please remember to sign your comments and posts by typing four tildes (like this: ~~~~) before saving: it makes it easier to identify who said what and prevents confusion. Fvasconcellos 19:38, 15 September 2006 (UTC)

I think information regarding the history of the drug and how it was developed should be added to this and all drugs on Wikipedia. This information should include the date it was first available to patients.