Keratin 7

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Keratin 7
Identifiers
Symbol(s) KRT7; CK7; K2C7; K7; MGC129731; MGC3625; SCL
External IDs OMIM: 148059 MGI: 96704 HomoloGene: 4058
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3855 110310
Ensembl ENSG00000135480 ENSMUSG00000023039
Uniprot P08729 n/a
Refseq NM_005556 (mRNA)
NP_005547 (protein)		 NM_033073 (mRNA)
NP_149064 (protein)
Location Chr 12: 50.91 - 50.93 Mb Chr 15: 101.24 - 101.26 Mb
Pubmed search [1] [2]

Keratin 7, also known as KRT7, is a human gene.[1]

Keratin 7 is a member of the keratin family. It is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels.

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described.[1]

[edit] References

  1. ^ a b Entrez Gene: KRT7 keratin 7.

[edit] Further reading

  • Bouwens L (1998). "Cytokeratins and cell differentiation in the pancreas.". J. Pathol. 184 (3): 234-9. doi:10.1002/(SICI)1096-9896(199803)184:3<234::AID-PATH28>3.0.CO;2-D. PMID 9614373. 
  • Rosenberg M, Fuchs E, Le Beau MM, et al. (1991). "Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12.". Cytogenet. Cell Genet. 57 (1): 33-8. PMID 1713141. 
  • Glass C, Kim KH, Fuchs E (1986). "Sequence and expression of a human type II mesothelial keratin.". J. Cell Biol. 101 (6): 2366-73. PMID 2415537. 
  • Ramaekers F, Huysmans A, Schaart G, et al. (1987). "Tissue distribution of keratin 7 as monitored by a monoclonal antibody.". Exp. Cell Res. 170 (1): 235-49. doi:10.1016/0014-4827(87)90133-9. PMID 2436934. 
  • Glass C, Fuchs E (1988). "Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells.". J. Cell Biol. 107 (4): 1337-50. doi:10.1083/jcb.107.4.1337. PMID 2459129. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile.". Oncogene 13 (8): 1819-30. PMID 8895530. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Alvarez Alvarez C, Sánchez Merino JM, Busto Castañón L, et al. (1998). "[Mucinous adenocarcinoma of the urachus synchronic with colorectal adenocarcinoma. Value of immunohistochemistry in the differential diagnosis]". Actas urologicas españolas 22 (6): 515-8. PMID 9734130. 
  • Kaba A, Jiang PH, Chany-Fournier F, Chany C (1999). "Sarcolectin (SCL): structure and expression of the recombinant molecule.". Biochimie 81 (7): 709-15. doi:10.1016/S0300-9084(99)80128-X. PMID 10492017. 
  • Lin L, Holbro T, Alonso G, et al. (2001). "Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7.". J. Cell. Biochem. 80 (4): 483-90. doi:10.1002/1097-4644(20010315)80:4<483::AID-JCB1002>3.0.CO;2-B. PMID 11169732. 
  • Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758-65. doi:10.1101/gr.180101. PMID 11591653. 
  • Harris RA, Yang A, Stein RC, et al. (2002). "Cluster analysis of an extensive human breast cancer cell line protein expression map database.". Proteomics 2 (2): 212-23. doi:10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO;2-H. PMID 11840567. 
  • Bonvini P, Gastaldi T, Falini B, Rosolen A (2002). "Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin.". Cancer Res. 62 (5): 1559-66. PMID 11888936. 
  • Jovanovic I, Tzardi M, Mouzas IA, et al. (2002). "Changing pattern of cytokeratin 7 and 20 expression from normal epithelium to intestinal metaplasia of the gastric mucosa and gastroesophageal junction.". Histol. Histopathol. 17 (2): 445-54. PMID 11962749. 
  • Kanduc D (2002). "Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7.". J. Virol. 76 (14): 7040-8. doi:10.1128/JVI.76.14.7040-7048.2002. PMID 12072504. 
  • Smith FJ, Porter RM, Corden LD, et al. (2002). "Cloning of human, murine, and marsupial keratin 7 and a survey of K7 expression in the mouse.". Biochem. Biophys. Res. Commun. 297 (4): 818-27. doi:10.1016/S0006-291X(02)02288-X. PMID 12359226. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Blagoev B, Kratchmarova I, Ong SE, et al. (2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.". Nat. Biotechnol. 21 (3): 315-8. doi:10.1038/nbt790. PMID 12577067. 
 This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it.


 This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it.
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Protein: fibrous proteins
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Keratin/Cytokeratin
type I (10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21), type II (1, 2A, 3, 4, 5, 6A, 7, 8, 9), Hair (Type I, Type II), Beta
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