Keratin 17

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Keratin 17
Identifiers
Symbol(s) KRT17; PC2; K17; PC; PCHC1
External IDs OMIM: 148069 MGI: 96691 HomoloGene: 363
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3872 16667
Ensembl ENSG00000186831 ENSMUSG00000035557
Uniprot Q04695 Q9QWL7
Refseq NM_000422 (mRNA)
NP_000413 (protein)		 NM_010663 (mRNA)
NP_034793 (protein)
Location Chr 17: 37.03 - 37.03 Mb Chr 11: 100.07 - 100.08 Mb
Pubmed search [1] [2]

Keratin 17, also known as KRT17, is a human gene.[1]

Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.[1]

[edit] References

  1. ^ a b Entrez Gene: KRT17 keratin 17.

[edit] Further reading

  • Troyanovsky SM, Leube RE, Franke WW (1993). "Characterization of the human gene encoding cytokeratin 17 and its expression pattern.". Eur. J. Cell Biol. 59 (1): 127-37. PMID 1281771. 
  • Flohr T, Buwitt U, Bonnekoh B, et al. (1992). "Interferon-gamma regulates expression of a novel keratin class I gene.". Eur. J. Immunol. 22 (4): 975-9. doi:10.1002/eji.1830220415. PMID 1372562. 
  • Trask DK, Band V, Zajchowski DA, et al. (1990). "Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells.". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2319-23. doi:10.1073/pnas.87.6.2319. PMID 1690428. 
  • Kartasova T, Cornelissen BJ, Belt P, van de Putte P (1987). "Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes.". Nucleic Acids Res. 15 (15): 5945-62. doi:10.1093/nar/15.15.5945. PMID 2442723. 
  • Takahashi K, Folmer J, Coulombe PA (1994). "Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin.". J. Cell Biol. 127 (2): 505-20. doi:10.1083/jcb.127.2.505. PMID 7523421. 
  • Munro CS, Carter S, Bryce S, et al. (1995). "A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21.". J. Med. Genet. 31 (9): 675-8. PMID 7529318. 
  • McLean WH, Rugg EL, Lunny DP, et al. (1995). "Keratin 16 and keratin 17 mutations cause pachyonychia congenita.". Nat. Genet. 9 (3): 273-8. doi:10.1038/ng0395-273. PMID 7539673. 
  • Leigh IM, Navsaria H, Purkis PE, et al. (1995). "Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro.". Br. J. Dermatol. 133 (4): 501-11. doi:10.1111/j.1365-2133.1995.tb02696.x. PMID 7577575. 
  • Smith FJ, Corden LD, Rugg EL, et al. (1997). "Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex.". J. Invest. Dermatol. 108 (2): 220-3. doi:10.1111/1523-1747.ep12335315. PMID 9008238. 
  • Covello SP, Smith FJ, Sillevis Smitt JH, et al. (1999). "Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2.". Br. J. Dermatol. 139 (3): 475-80. PMID 9767294. 
  • McGowan KM, Coulombe PA (1998). "Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development.". J. Cell Biol. 143 (2): 469-86. doi:10.1083/jcb.143.2.469. PMID 9786956. 
  • Schön M, Benwood J, O'Connell-Willstaedt T, Rheinwald JG (1999). "Human sweat gland myoepithelial cells express a unique set of cytokeratins and reveal the potential for alternative epithelial and mesenchymal differentiation states in culture.". J. Cell. Sci. 112 ( Pt 12): 1925-36. PMID 10341211. 
  • Celebi JT, Tanzi EL, Yao YJ, et al. (1999). "Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2.". J. Invest. Dermatol. 113 (5): 848-50. doi:10.1046/j.1523-1747.1999.00762.x. PMID 10571744. 
  • Smith FJ, Coleman CM, Bayoumy NM, et al. (2001). "Novel keratin 17 mutations in pachyonychia congenita type 2.". J. Invest. Dermatol. 116 (5): 806-8. doi:10.1046/j.0022-202x.2001.doc.x. PMID 11348474. 
  • Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758-65. doi:10.1101/gr.180101. PMID 11591653. 
  • Hashiguchi T, Yotsumoto S, Shimada H, et al. (2002). "A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2.". J. Invest. Dermatol. 118 (3): 545-7. doi:10.1046/j.0022-202x.2001.01701.x. PMID 11874497. 
  • Terrinoni A, Smith FJ, Didona B, et al. (2002). "Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita.". J. Invest. Dermatol. 117 (6): 1391-6. doi:10.1046/j.0022-202x.2001.01565.x. PMID 11886499. 
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100-9. doi:10.1091/mbc.E02-05-0271. PMID 12429849. 
  • van de Rijn M, Perou CM, Tibshirani R, et al. (2003). "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome.". Am. J. Pathol. 161 (6): 1991-6. PMID 12466114. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
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Protein: fibrous proteins
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Keratin/Cytokeratin
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