JWH-200
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JWH-200
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| Systematic (IUPAC) name | |
| (1-(2-morpholin-4-ylethyl)indol-3-yl)-naphthalen-1-ylmethanone | |
| Identifiers | |
| CAS number | ? |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C25H24N2O2 |
| Mol. mass | 384.469 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status |
Legal |
| Routes | ? |
JWH-200 is an analgesic drug from the aminoalkylindole family, which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 42nM, around the same as that of THC,[1] but interestingly its analgesic potency in vivo was higher than that of other analogues which had stronger CB1 binding affinity in vitro,[2] around 3x that of THC but with less sedative effect,[3] most likely reflecting favourable pharmacokinetic characteristics.
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[edit] References
- ^ Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411.
- ^ Bell MR, D'Ambra TE, Kumar V, et al (1991). Antinociceptive (aminoalkyl)indoles. Journal of Medicinal Chemistry. 34 (3): 1099–1110. PMID 1900533
- ^ Compton DR, Gold LH, Ward SJ, Balster RL, Martin BR (1992). Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol. Journal of Pharmacology and Experimental Therapeutics. 263 (3): 1118–26. PMID 1335057
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