From Wikipedia, the free encyclopedia
Log page index: User:JonSDSUGrad/Sandbox/PBB_Log_Index
This is a Dry run only, no pages were created, updated, or modified in any way.
[edit] Page Match Grid
[edit] Protein Dry Status Log - Date: 23:43, 12 August 2007 (UTC)
[edit] Conflict: Ambiguous Proteins (15)
[edit] Proteins without matches (3)
[edit] Proteins with a High Potential Match (6)
[edit] Redirected Proteins (9)
[edit] Protein Status Log - Date: 23:43, 12 August 2007 (UTC)
[edit] Unresolved Status (18)
[edit] Skipped: Ambiguous Pages (15)
[edit] Condensed Log - Date: 23:43, 12 August 2007 (UTC)
[edit] Skipped Proteins (21)
[edit] Redirected Proteins (9)
[edit] Vebose Log - Date: 23:43, 12 August 2007 (UTC)
AKT1
- REDIRECT: Protein Redirected to: AKT {August 12, 2007 4:31:23 PM PDT}
APOE
- REDIRECT: Protein Redirected to: Apolipoprotein E {August 12, 2007 4:31:23 PM PDT}
APP
AR
- AMBIGUITY: More than one potential page found for updating, AR AIS Ais KD Kd SBMA TFM {August 12, 2007 4:32:19 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1e3g}}, {{PDB2|1gs4}}, {{PDB2|1i37}}, {{PDB2|1i38}}, {{PDB2|1r4i}}, {{PDB2|1t5z}}, {{PDB2|1t63}}, {{PDB2|1t65}}, {{PDB2|1t73}}, {{PDB2|1t74}}, {{PDB2|1t76}}, {{PDB2|1t79}}, {{PDB2|1t7f}}, {{PDB2|1t7m}}, {{PDB2|1t7r}}, {{PDB2|1t7t}}, {{PDB2|1xj7}}, {{PDB2|1xnn}}, {{PDB2|1xow}}, {{PDB2|1xq3}}, {{PDB2|1z95}}, {{PDB2|2am9}}, {{PDB2|2ama}}, {{PDB2|2amb}}, {{PDB2|2ao6}}, {{PDB2|2ax6}}, {{PDB2|2ax7}}, {{PDB2|2ax8}}, {{PDB2|2ax9}}, {{PDB2|2axa}}, {{PDB2|2ihq}}, {{PDB2|2nw4}}, {{PDB2|2oz7}}
| Name = androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)
| HGNCid = 644
| Symbol = AR
| AltSymbols =; AIS; DHTR; HUMARA; KD; NR3C4; SBMA; SMAX1; TFM
| OMIM = 313700
| ECnumber =
| Homologene = 28
| MGIid = 88064
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004882 |text = androgen receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0005497 |text = androgen binding}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007548 |text = sex differentiation}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0008584 |text = male gonad development}} {{GNF_GO|id=GO:0016049 |text = cell growth}} {{GNF_GO|id=GO:0019102 |text = male somatic sex determination}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0030850 |text = prostate gland development}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 367
| Hs_Ensembl = ENSG00000169083
| Hs_RefseqProtein = NP_000035
| Hs_RefseqmRNA = NM_000044
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 66681190
| Hs_GenLoc_end = 66867186
| Hs_Uniprot = P10275
| Mm_EntrezGene = 11835
| Mm_Ensembl = ENSMUSG00000046532
| Mm_RefseqmRNA = NM_013476
| Mm_RefseqProtein = NP_038504
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 94352469
| Mm_GenLoc_end = 94519866
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
<!-- BOT: SUMMARY END -->
BCL2
- REDIRECT: Protein Redirected to: Bcl-2 {August 12, 2007 4:32:19 PM PDT}
BRCA1
- AMBIGUITY: More than one potential page found for updating, BRCA1 IRIS Iris PSCP {August 12, 2007 4:32:46 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1jm7}}, {{PDB2|1jnx}}, {{PDB2|1n5o}}, {{PDB2|1oqa}}, {{PDB2|1t15}}, {{PDB2|1t29}}, {{PDB2|1t2u}}, {{PDB2|1t2v}}, {{PDB2|1y98}}
| Name = breast cancer 1, early onset
| HGNCid = 1100
| Symbol = BRCA1
| AltSymbols =; BRCAI; BRCC1; IRIS; PSCP; RNF53
| OMIM = 113705
| ECnumber =
| Homologene = 5276
| MGIid = 104537
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}} {{GNF_GO|id=GO:0000793 |text = condensed chromosome}} {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006359 |text = regulation of transcription from RNA polymerase III promoter}} {{GNF_GO|id=GO:0006633 |text = fatty acid biosynthetic process}} {{GNF_GO|id=GO:0006978 |text = DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007098 |text = centrosome cycle}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008274 |text = gamma-tubulin ring complex}} {{GNF_GO|id=GO:0008630 |text = DNA damage response, signal transduction resulting in induction of apoptosis}} {{GNF_GO|id=GO:0009048 |text = dosage compensation, by inactivation of X chromosome}} {{GNF_GO|id=GO:0015631 |text = tubulin binding}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0031398 |text = positive regulation of protein ubiquitination}} {{GNF_GO|id=GO:0031436 |text = BRCA1-BARD1 complex}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0045717 |text = negative regulation of fatty acid biosynthetic process}} {{GNF_GO|id=GO:0045739 |text = positive regulation of DNA repair}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0046600 |text = negative regulation of centriole replication}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 672
| Hs_Ensembl = ENSG00000012048
| Hs_RefseqProtein = NP_009226
| Hs_RefseqmRNA = NM_007295
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 38449840
| Hs_GenLoc_end = 38530994
| Hs_Uniprot = P38398
| Mm_EntrezGene = 12189
| Mm_Ensembl = ENSMUSG00000017146
| Mm_RefseqmRNA = NM_009764
| Mm_RefseqProtein = NP_033894
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 101305657
| Mm_GenLoc_end = 101367902
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified.
<!-- BOT: SUMMARY END -->
CASP3
- REDIRECT: Protein Redirected to: Caspase 3 {August 12, 2007 4:32:46 PM PDT}
CDKN1A
- REDIRECT: Protein Redirected to: p21 {August 12, 2007 4:32:46 PM PDT}
CDKN2A
- REDIRECT: Protein Redirected to: P16INK4a {August 12, 2007 4:32:47 PM PDT}
CTNNB1
- AMBIGUITY: Did not locate an acceptable page to update, but did find a redirect or disambig page: CTNNB1 {August 12, 2007 4:33:02 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1dow}}, {{PDB2|1g3j}}, {{PDB2|1i7w}}, {{PDB2|1i7x}}, {{PDB2|1jdh}}, {{PDB2|1jpp}}, {{PDB2|1jpw}}, {{PDB2|1luj}}, {{PDB2|1m1e}}, {{PDB2|1qz7}}, {{PDB2|1t08}}, {{PDB2|1th1}}, {{PDB2|1v18}}, {{PDB2|2bct}}, {{PDB2|2gl7}}, {{PDB2|3bct}}
| Name = catenin (cadherin-associated protein), beta 1, 88kDa
| HGNCid = 2514
| Symbol = CTNNB1
| AltSymbols =; CTNNB; FLJ25606
| OMIM = 116806
| ECnumber =
| Homologene = 1434
| MGIid = 88276
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0000904 |text = cellular morphogenesis during differentiation}} {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001569 |text = patterning of blood vessels}} {{GNF_GO|id=GO:0001706 |text = endoderm formation}} {{GNF_GO|id=GO:0001708 |text = cell fate specification}} {{GNF_GO|id=GO:0001709 |text = cell fate determination}} {{GNF_GO|id=GO:0001711 |text = endodermal cell fate commitment}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005913 |text = cell-cell adherens junction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007398 |text = ectoderm development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0009950 |text = dorsal/ventral axis specification}} {{GNF_GO|id=GO:0009954 |text = proximal/distal pattern formation}} {{GNF_GO|id=GO:0010003 |text = gastrulation (sensu Mammalia)}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}} {{GNF_GO|id=GO:0016328 |text = lateral plasma membrane}} {{GNF_GO|id=GO:0016331 |text = morphogenesis of embryonic epithelium}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0030316 |text = osteoclast differentiation}} {{GNF_GO|id=GO:0030324 |text = lung development}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0030858 |text = positive regulation of epithelial cell differentiation}} {{GNF_GO|id=GO:0030900 |text = forebrain development}} {{GNF_GO|id=GO:0031016 |text = pancreas development}} {{GNF_GO|id=GO:0031528 |text = microvillus membrane}} {{GNF_GO|id=GO:0035116 |text = embryonic hindlimb morphogenesis}} {{GNF_GO|id=GO:0035117 |text = embryonic arm morphogenesis}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0042733 |text = embryonic digit morphogenesis}} {{GNF_GO|id=GO:0045177 |text = apical part of cell}} {{GNF_GO|id=GO:0045294 |text = alpha-catenin binding}} {{GNF_GO|id=GO:0045296 |text = cadherin binding}} {{GNF_GO|id=GO:0045453 |text = bone resorption}} {{GNF_GO|id=GO:0045596 |text = negative regulation of cell differentiation}} {{GNF_GO|id=GO:0045669 |text = positive regulation of osteoblast differentiation}} {{GNF_GO|id=GO:0045671 |text = negative regulation of osteoclast differentiation}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048469 |text = cell maturation}} {{GNF_GO|id=GO:0048489 |text = synaptic vesicle transport}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}} {{GNF_GO|id=GO:0050808 |text = synapse organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1499
| Hs_Ensembl = ENSG00000168036
| Hs_RefseqProtein = XP_001133660
| Hs_RefseqmRNA = XM_001133660
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 41216004
| Hs_GenLoc_end = 41256938
| Hs_Uniprot = P35222
| Mm_EntrezGene = 12387
| Mm_Ensembl = ENSMUSG00000006932
| Mm_RefseqmRNA = NM_007614
| Mm_RefseqProtein = NP_031640
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 120782173
| Mm_GenLoc_end = 120809205
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]
<!-- BOT: SUMMARY END -->
EGFR
- AMBIGUITY: More than one potential page found for updating, EGFR mENA Mena {August 12, 2007 4:33:29 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1ivo}}, {{PDB2|1m14}}, {{PDB2|1m17}}, {{PDB2|1mox}}, {{PDB2|1nql}}, {{PDB2|1xkk}}, {{PDB2|1yy9}}, {{PDB2|1z9i}}, {{PDB2|2gs2}}, {{PDB2|2gs6}}, {{PDB2|2gs7}}, {{PDB2|2itn}}, {{PDB2|2ito}}, {{PDB2|2itp}}, {{PDB2|2itq}}, {{PDB2|2itt}}, {{PDB2|2itu}}, {{PDB2|2itv}}, {{PDB2|2itw}}, {{PDB2|2itx}}, {{PDB2|2ity}}, {{PDB2|2itz}}, {{PDB2|2j5e}}, {{PDB2|2j5f}}, {{PDB2|2j6m}}
| Name = epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
| HGNCid = 3236
| Symbol = EGFR
| AltSymbols =; ERBB; ERBB1; mENA
| OMIM = 131550
| ECnumber =
| Homologene = 74545
| MGIid = 95294
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0004710 |text = MAP/ERK kinase kinase activity}} {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005006 |text = epidermal growth factor receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007202 |text = phospholipase C activation}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030122 |text = AP-2 adaptor complex}} {{GNF_GO|id=GO:0030139 |text = endocytic vesicle}} {{GNF_GO|id=GO:0030235 |text = nitric-oxide synthase regulator activity}} {{GNF_GO|id=GO:0030335 |text = positive regulation of cell migration}} {{GNF_GO|id=GO:0042327 |text = positive regulation of phosphorylation}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0043006 |text = calcium-dependent phospholipase A2 activation}} {{GNF_GO|id=GO:0043406 |text = positive regulation of MAPK activity}} {{GNF_GO|id=GO:0045429 |text = positive regulation of nitric oxide biosynthetic process}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}} {{GNF_GO|id=GO:0050679 |text = positive regulation of epithelial cell proliferation}} {{GNF_GO|id=GO:0050730 |text = regulation of peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0050999 |text = regulation of nitric-oxide synthase activity}} {{GNF_GO|id=GO:0051015 |text = actin filament binding}} {{GNF_GO|id=GO:0051205 |text = protein insertion into membrane}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1956
| Hs_Ensembl = ENSG00000146648
| Hs_RefseqProtein = NP_005219
| Hs_RefseqmRNA = NM_005228
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 55054219
| Hs_GenLoc_end = 55242524
| Hs_Uniprot = P00533
| Mm_EntrezGene = 13649
| Mm_Ensembl = ENSMUSG00000020122
| Mm_RefseqmRNA = NM_007912
| Mm_RefseqProtein = NP_031938
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 16652206
| Mm_GenLoc_end = 16813912
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
<!-- No Summary Available -->
<!-- BOT: SUMMARY END -->
ERBB2
- REDIRECT: Protein Redirected to: HER2 {August 12, 2007 4:33:29 PM PDT}
ESR1
- AMBIGUITY: More than one potential page found for updating, ESR1 ER Er ESR Esr ESRA Era Era {August 12, 2007 4:34:21 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1a52}}, {{PDB2|1ere}}, {{PDB2|1err}}, {{PDB2|1g50}}, {{PDB2|1gwq}}, {{PDB2|1gwr}}, {{PDB2|1hcp}}, {{PDB2|1hcq}}, {{PDB2|1l2i}}, {{PDB2|1pcg}}, {{PDB2|1qkt}}, {{PDB2|1qku}}, {{PDB2|1r5k}}, {{PDB2|1sj0}}, {{PDB2|1uom}}, {{PDB2|1x7e}}, {{PDB2|1x7r}}, {{PDB2|1xp1}}, {{PDB2|1xp6}}, {{PDB2|1xp9}}, {{PDB2|1xpc}}, {{PDB2|1xqc}}, {{PDB2|1yim}}, {{PDB2|1yin}}, {{PDB2|1zky}}, {{PDB2|2ayr}}, {{PDB2|2b1v}}, {{PDB2|2b1z}}, {{PDB2|2b23}}, {{PDB2|2bj4}}, {{PDB2|2fai}}, {{PDB2|2g44}}, {{PDB2|2g5o}}, {{PDB2|2i0j}}, {{PDB2|2jf9}}, {{PDB2|2jfa}}, {{PDB2|2ouz}}, {{PDB2|2p15}}, {{PDB2|3erd}}, {{PDB2|3ert}}
| Name = estrogen receptor 1
| HGNCid = 3467
| Symbol = ESR1
| AltSymbols =; ER; DKFZp686N23123; ESR; ESRA; Era; NR3A1
| OMIM = 133430
| ECnumber =
| Homologene = 47906
| MGIid = 1352467
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016049 |text = cell growth}} {{GNF_GO|id=GO:0016585 |text = chromatin remodeling complex}} {{GNF_GO|id=GO:0030235 |text = nitric-oxide synthase regulator activity}} {{GNF_GO|id=GO:0030284 |text = estrogen receptor activity}} {{GNF_GO|id=GO:0030520 |text = estrogen receptor signaling pathway}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0045839 |text = negative regulation of mitosis}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2099
| Hs_Ensembl = ENSG00000091831
| Hs_RefseqProtein = NP_000116
| Hs_RefseqmRNA = NM_000125
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 152170379
| Hs_GenLoc_end = 152466099
| Hs_Uniprot = P03372
| Mm_EntrezGene = 13982
| Mm_Ensembl = ENSMUSG00000019768
| Mm_RefseqmRNA = XM_985634
| Mm_RefseqProtein = XP_990728
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 5342780
| Mm_GenLoc_end = 5734495
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ESR1 mRNA transcripts, which differ primarily in their 5-prime untranslated regions. The translated receptors show less variability.[supplied by OMIM]
<!-- BOT: SUMMARY END -->
HLA-B
- SEARCH REDIRECT: One high potential page found for updating: HLA-B {August 12, 2007 4:35:00 PM PDT}
IGF1
- AMBIGUITY: Did not locate an acceptable page to update, but did find a redirect or disambig page: IGF1 {August 12, 2007 4:35:06 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1bqt}}, {{PDB2|1gzr}}, {{PDB2|1gzy}}, {{PDB2|1gzz}}, {{PDB2|1h02}}, {{PDB2|1h59}}, {{PDB2|1imx}}, {{PDB2|1pmx}}, {{PDB2|1wqj}}, {{PDB2|2dsp}}, {{PDB2|2dsq}}, {{PDB2|2dsr}}, {{PDB2|2gf1}}, {{PDB2|3gf1}}, {{PDB2|3lri}}
| Name = insulin-like growth factor 1 (somatomedin C)
| HGNCid = 5464
| Symbol = IGF1
| AltSymbols =; IGFI
| OMIM = 147440
| ECnumber =
| Homologene = 515
| MGIid = 96432
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0005159 |text = insulin-like growth factor receptor binding}} {{GNF_GO|id=GO:0005179 |text = hormone activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0009441 |text = glycolate metabolic process}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0010001 |text = glial cell differentiation}} {{GNF_GO|id=GO:0018445 |text = prothoracicotrophic hormone activity}} {{GNF_GO|id=GO:0048009 |text = insulin-like growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0048468 |text = cell development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3479
| Hs_Ensembl = ENSG00000017427
| Hs_RefseqProtein = NP_000609
| Hs_RefseqmRNA = NM_000618
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 101313809
| Hs_GenLoc_end = 101398471
| Hs_Uniprot = P01343
| Mm_EntrezGene = 16000
| Mm_Ensembl = ENSMUSG00000020053
| Mm_RefseqmRNA = NM_010512
| Mm_RefseqProtein = NP_034642
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 87288867
| Mm_GenLoc_end = 87361600
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986; Rosenfeld, 2003).[supplied by OMIM]
<!-- BOT: SUMMARY END -->
IL10
- SEARCH REDIRECT: One high potential page found for updating: interleukin 10 {August 12, 2007 4:37:05 PM PDT}
IL1B
- SEARCH REDIRECT: One high potential page found for updating: IL1B {August 12, 2007 4:35:29 PM PDT}
IL6
- AMBIGUITY: More than one potential page found for updating, IL6 Hgf HSF IL-6 Il-6 {August 12, 2007 4:35:48 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1alu}}, {{PDB2|1il6}}, {{PDB2|1p9m}}, {{PDB2|2il6}}
| Name = interleukin 6 (interferon, beta 2)
| HGNCid = 6018
| Symbol = IL6
| AltSymbols =; HGF; BSF2; HSF; IFNB2; IL-6
| OMIM = 147620
| ECnumber =
| Homologene = 502
| MGIid = 96559
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0001781 |text = neutrophil apoptosis}} {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005138 |text = interleukin-6 receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0006959 |text = humoral immune response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}} {{GNF_GO|id=GO:0045079 |text = negative regulation of chemokine biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3569
| Hs_Ensembl = ENSG00000136244
| Hs_RefseqProtein = NP_000591
| Hs_RefseqmRNA = NM_000600
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 22732028
| Hs_GenLoc_end = 22738091
| Hs_Uniprot = P05231
| Mm_EntrezGene = 16193
| Mm_Ensembl = ENSMUSG00000025746
| Mm_RefseqmRNA = NM_031168
| Mm_RefseqProtein = NP_112445
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 30343948
| Mm_GenLoc_end = 30350755
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
<!-- No Summary Available -->
<!-- BOT: SUMMARY END -->
IL8
- SEARCH REDIRECT: One high potential page found for updating: interleukin 8 {August 12, 2007 4:36:44 PM PDT}
ITGB1
- SEARCH REDIRECT: One high potential page found for updating: CD29 {August 12, 2007 4:37:27 PM PDT}
MAPK1
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1erk}}, {{PDB2|1gol}}, {{PDB2|1pme}}, {{PDB2|1tvo}}, {{PDB2|1wzy}}, {{PDB2|2erk}}, {{PDB2|2fys}}, {{PDB2|2gph}}, {{PDB2|2ojg}}, {{PDB2|2oji}}, {{PDB2|2ojj}}, {{PDB2|3erk}}, {{PDB2|4erk}}
| Name = mitogen-activated protein kinase 1
| HGNCid = 6871
| Symbol = MAPK1
| AltSymbols =; p38; ERK; p40; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p41; p41mapk
| OMIM = 176948
| ECnumber =
| Homologene = 37670
| MGIid = 1346858
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000165 |text = MAPKKK cascade}} {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0001784 |text = phosphotyrosine binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004707 |text = MAP kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006974 |text = response to DNA damage stimulus}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019858 |text = cytosine metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5594
| Hs_Ensembl = ENSG00000100030
| Hs_RefseqProtein = NP_620407
| Hs_RefseqmRNA = NM_138957
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 20446873
| Hs_GenLoc_end = 20551730
| Hs_Uniprot = P28482
| Mm_EntrezGene = 26413
| Mm_Ensembl = ENSMUSG00000063358
| Mm_RefseqmRNA = NM_001038663
| Mm_RefseqProtein = NP_001033752
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 16896945
| Mm_GenLoc_end = 16961016
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
<!-- BOT: SUMMARY END -->
MMP9
- REDIRECT: Protein Redirected to: MMP9 {August 12, 2007 4:37:27 PM PDT}
PRKCA
- AMBIGUITY: More than one potential page found for updating, PKC-alpha Pkc-alpha {August 12, 2007 4:38:26 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1dsy}}
| Name = protein kinase C, alpha
| HGNCid = 9393
| Symbol = PRKCA
| AltSymbols =; PRKACA; AAG6; MGC129900; MGC129901; PKC-alpha; PKCA
| OMIM = 176960
| ECnumber =
| Homologene = 55679
| MGIid = 97595
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000188 |text = inactivation of MAPK activity}} {{GNF_GO|id=GO:0001933 |text = negative regulation of protein amino acid phosphorylation}} {{GNF_GO|id=GO:0001934 |text = positive regulation of protein amino acid phosphorylation}} {{GNF_GO|id=GO:0002026 |text = cardiac inotropy}} {{GNF_GO|id=GO:0004698 |text = calcium-dependent protein kinase C activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006469 |text = negative regulation of protein kinase activity}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0006937 |text = regulation of muscle contraction}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008624 |text = induction of apoptosis by extracellular signals}} {{GNF_GO|id=GO:0008629 |text = induction of apoptosis by intracellular signals}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0030593 |text = neutrophil chemotaxis}} {{GNF_GO|id=GO:0046325 |text = negative regulation of glucose import}} {{GNF_GO|id=GO:0046627 |text = negative regulation of insulin receptor signaling pathway}} {{GNF_GO|id=GO:0050729 |text = positive regulation of inflammatory response}} {{GNF_GO|id=GO:0050730 |text = regulation of peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0050930 |text = induction of positive chemotaxis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5578
| Hs_Ensembl = ENSG00000154229
| Hs_RefseqProtein = NP_002728
| Hs_RefseqmRNA = NM_002737
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 61729388
| Hs_GenLoc_end = 62237324
| Hs_Uniprot = P17252
| Mm_EntrezGene = 18750
| Mm_Ensembl = ENSMUSG00000050965
| Mm_RefseqmRNA = NM_011101
| Mm_RefseqProtein = NP_035231
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 107754338
| Mm_GenLoc_end = 108159844
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
<!-- BOT: SUMMARY END -->
PTGS2
- AMBIGUITY: More than one potential page found for updating, COX2 COX-2 Cox-2 {August 12, 2007 4:39:22 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
| HGNCid = 9605
| Symbol = PTGS2
| AltSymbols =; COX2; PGG/HS; COX-2; PGHS-2; PHS-2; hCox-2
| OMIM = 600262
| ECnumber =
| Homologene = 31000
| MGIid = 97798
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0001516 |text = prostaglandin biosynthetic process}} {{GNF_GO|id=GO:0004601 |text = peroxidase activity}} {{GNF_GO|id=GO:0004666 |text = prostaglandin-endoperoxide synthase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0006633 |text = fatty acid biosynthetic process}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0016702 |text = oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen}} {{GNF_GO|id=GO:0019371 |text = cyclooxygenase pathway}} {{GNF_GO|id=GO:0030216 |text = keratinocyte differentiation}} {{GNF_GO|id=GO:0042640 |text = anagen}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050727 |text = regulation of inflammatory response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5743
| Hs_Ensembl = ENSG00000073756
| Hs_RefseqProtein = NP_000954
| Hs_RefseqmRNA = NM_000963
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 184907546
| Hs_GenLoc_end = 184916178
| Hs_Uniprot = P35354
| Mm_EntrezGene = 19225
| Mm_Ensembl = ENSMUSG00000032487
| Mm_RefseqmRNA = NM_011198
| Mm_RefseqProtein = NP_035328
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 151862342
| Mm_GenLoc_end = 151870203
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS2, which shows 86% - 89% amino acid sequence identity with mouse, rat, sheep, bovine, horse and rabit PTGS2 proteins, respectively. Human PTGS2 is expressed in a limited number of cell types and regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. The expression of this gene is deregulated in epithelial tumors.
<!-- BOT: SUMMARY END -->
RB1
- AMBIGUITY: More than one potential page found for updating, RB1 RB Rb {August 12, 2007 4:39:32 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1ad6}}, {{PDB2|1gh6}}, {{PDB2|1gux}}, {{PDB2|1o9k}}, {{PDB2|2aze}}
| Name = retinoblastoma 1 (including osteosarcoma)
| HGNCid = 9884
| Symbol = RB1
| AltSymbols =; OSRC; RB
| OMIM = 180200
| ECnumber =
| Homologene = 272
| MGIid = 97874
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0000279 |text = M phase}} {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}} {{GNF_GO|id=GO:0005819 |text = spindle}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006469 |text = negative regulation of protein kinase activity}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0019900 |text = kinase binding}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0043550 |text = regulation of lipid kinase activity}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}} {{GNF_GO|id=GO:0051146 |text = striated muscle cell differentiation}} {{GNF_GO|id=GO:0051301 |text = cell division}} {{GNF_GO|id=GO:0051318 |text = G1 phase}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5925
| Hs_Ensembl = ENSG00000139687
| Hs_RefseqProtein = NP_000312
| Hs_RefseqmRNA = NM_000321
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 47775912
| Hs_GenLoc_end = 47954123
| Hs_Uniprot = P06400
| Mm_EntrezGene = 19645
| Mm_Ensembl = ENSMUSG00000022105
| Mm_RefseqmRNA = NM_009029
| Mm_RefseqProtein = NP_033055
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 71929657
| Mm_GenLoc_end = 72059946
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression ('cure') occurs in some cases.[supplied by OMIM]
<!-- BOT: SUMMARY END -->
SRC
- AMBIGUITY: More than one potential page found for updating, SRC ASV Asv {August 12, 2007 4:39:49 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1a07}}, {{PDB2|1a08}}, {{PDB2|1a09}}, {{PDB2|1a1a}}, {{PDB2|1a1b}}, {{PDB2|1a1c}}, {{PDB2|1a1e}}, {{PDB2|1bkl}}, {{PDB2|1bkm}}, {{PDB2|1f1w}}, {{PDB2|1f2f}}, {{PDB2|1fmk}}, {{PDB2|1hcs}}, {{PDB2|1hct}}, {{PDB2|1is0}}, {{PDB2|1kc2}}, {{PDB2|1ksw}}, {{PDB2|1nlo}}, {{PDB2|1nlp}}, {{PDB2|1nzl}}, {{PDB2|1nzv}}, {{PDB2|1o41}}, {{PDB2|1o42}}, {{PDB2|1o43}}, {{PDB2|1o44}}, {{PDB2|1o45}}, {{PDB2|1o46}}, {{PDB2|1o47}}, {{PDB2|1o48}}, {{PDB2|1o49}}, {{PDB2|1o4a}}, {{PDB2|1o4b}}, {{PDB2|1o4c}}, {{PDB2|1o4d}}, {{PDB2|1o4e}}, {{PDB2|1o4f}}, {{PDB2|1o4g}}, {{PDB2|1o4h}}, {{PDB2|1o4i}}, {{PDB2|1o4j}}, {{PDB2|1o4k}}, {{PDB2|1o4l}}, {{PDB2|1o4m}}, {{PDB2|1o4n}}, {{PDB2|1o4o}}, {{PDB2|1o4p}}, {{PDB2|1o4q}}, {{PDB2|1o4r}}, {{PDB2|1p13}}, {{PDB2|1prl}}, {{PDB2|1prm}}, {{PDB2|1qwe}}, {{PDB2|1qwf}}, {{PDB2|1rlp}}, {{PDB2|1rlq}}, {{PDB2|1sha}}, {{PDB2|1shb}}, {{PDB2|1shd}}, {{PDB2|1skj}}, {{PDB2|1spr}}, {{PDB2|1sps}}, {{PDB2|1srl}}, {{PDB2|1srm}}, {{PDB2|1y57}}, {{PDB2|1yi6}}, {{PDB2|1yoj}}, {{PDB2|1yol}}, {{PDB2|1yom}}, {{PDB2|2bdf}}, {{PDB2|2bdj}}, {{PDB2|2h8h}}, {{PDB2|2hwo}}, {{PDB2|2hwp}}, {{PDB2|2oiq}}, {{PDB2|2ptk}}, {{PDB2|2src}}
| Name = v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
| HGNCid = 11283
| Symbol = SRC
| AltSymbols =; ASV; SRC1; c-SRC; p60-Src
| OMIM = 190090
| ECnumber =
| Homologene = 21120
| MGIid = 98397
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007172 |text = signal complex assembly}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042169 |text = SH2 domain binding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6714
| Hs_Ensembl = ENSG00000197122
| Hs_RefseqProtein = NP_005408
| Hs_RefseqmRNA = NM_005417
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 35406502
| Hs_GenLoc_end = 35467239
| Hs_Uniprot = P12931
| Mm_EntrezGene = 20779
| Mm_Ensembl = ENSMUSG00000027646
| Mm_RefseqmRNA = NM_001025395
| Mm_RefseqProtein = NP_001020566
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 157115730
| Mm_GenLoc_end = 157163279
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
<!-- BOT: SUMMARY END -->
TGFB1
- AMBIGUITY: Did not locate an acceptable page to update, but did find a redirect or disambig page: CED {August 12, 2007 4:40:02 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1kla}}, {{PDB2|1klc}}, {{PDB2|1kld}}
| Name = transforming growth factor, beta 1
| HGNCid = 11766
| Symbol = TGFB1
| AltSymbols =; CED; DPD1; TGFB
| OMIM = 190180
| ECnumber =
| Homologene = 540
| MGIid = 98725
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0005160 |text = transforming growth factor beta receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0008219 |text = cell death}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0008354 |text = germ cell migration}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0016049 |text = cell growth}} {{GNF_GO|id=GO:0016202 |text = regulation of striated muscle development}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0030279 |text = negative regulation of ossification}} {{GNF_GO|id=GO:0042306 |text = regulation of protein import into nucleus}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0048298 |text = positive regulation of isotype switching to IgA isotypes}} {{GNF_GO|id=GO:0048535 |text = lymph node development}} {{GNF_GO|id=GO:0051101 |text = regulation of DNA binding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7040
| Hs_Ensembl = ENSG00000105329
| Hs_RefseqProtein = NP_000651
| Hs_RefseqmRNA = NM_000660
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 46528254
| Hs_GenLoc_end = 46551628
| Hs_Uniprot = P01137
| Mm_EntrezGene = 21803
| Mm_Ensembl = ENSMUSG00000002603
| Mm_RefseqmRNA = NM_011577
| Mm_RefseqProtein = NP_035707
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 25395762
| Mm_GenLoc_end = 25413756
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM]
<!-- BOT: SUMMARY END -->
TNF
- AMBIGUITY: More than one potential page found for updating, TNF DIF TNF-alpha Tnfa {August 12, 2007 4:41:22 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1a8m}}, {{PDB2|1tnf}}, {{PDB2|2az5}}, {{PDB2|2tun}}, {{PDB2|4tsv}}, {{PDB2|5tsw}}
| Name = tumor necrosis factor (TNF superfamily, member 2)
| HGNCid = 11892
| Symbol = TNF
| AltSymbols =; DIF; TNF-alpha; TNFA; TNFSF2
| OMIM = 191160
| ECnumber =
| Homologene = 496
| MGIid = 104798
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000060 |text = protein import into nucleus, translocation}} {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0001932 |text = regulation of protein amino acid phosphorylation}} {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005164 |text = tumor necrosis factor receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0006006 |text = glucose metabolic process}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006959 |text = humoral immune response}} {{GNF_GO|id=GO:0007159 |text = leukocyte adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008625 |text = induction of apoptosis via death domain receptors}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0045123 |text = cellular extravasation}} {{GNF_GO|id=GO:0045670 |text = regulation of osteoclast differentiation}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045994 |text = positive regulation of translational initiation by iron}} {{GNF_GO|id=GO:0046325 |text = negative regulation of glucose import}} {{GNF_GO|id=GO:0046330 |text = positive regulation of JNK cascade}} {{GNF_GO|id=GO:0051023 |text = regulation of immunoglobulin secretion}} {{GNF_GO|id=GO:0051092 |text = activation of NF-kappaB transcription factor}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7124
| Hs_Ensembl = ENSG00000204490
| Hs_RefseqProtein = NP_000585
| Hs_RefseqmRNA = NM_000594
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 31651314
| Hs_GenLoc_end = 31654092
| Hs_Uniprot = P01375
| Mm_EntrezGene = 21926
| Mm_Ensembl = ENSMUSG00000024401
| Mm_RefseqmRNA = NM_013693
| Mm_RefseqProtein = NP_038721
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 34807442
| Mm_GenLoc_end = 34810048
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
<!-- BOT: SUMMARY END -->
TP53
- SEARCH REDIRECT: One high potential page found for updating: P53 {August 12, 2007 4:41:35 PM PDT}
VEGFA
- AMBIGUITY: More than one potential page found for updating, VEGF VEGF-A {August 12, 2007 4:41:51 PM PDT}
<!-- BOT: MANUAL_INSPECTION_REQUIRED = NO - change this option to YES to have the protein box bot require an operator inspection before updating occurs. -->
<!-- BOT: PROTEIN BOX UPDATE = YES - This protein box is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this protein box -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1bj1}}, {{PDB2|1cz8}}, {{PDB2|1flt}}, {{PDB2|1kat}}, {{PDB2|1kmx}}, {{PDB2|1mjv}}, {{PDB2|1mkg}}, {{PDB2|1mkk}}, {{PDB2|1qty}}, {{PDB2|1tzh}}, {{PDB2|1tzi}}, {{PDB2|1vgh}}, {{PDB2|1vpf}}, {{PDB2|1vpp}}, {{PDB2|2fjg}}, {{PDB2|2fjh}}, {{PDB2|2vgh}}, {{PDB2|2vpf}}
| Name = vascular endothelial growth factor A
| HGNCid = 12680
| Symbol = VEGFA
| AltSymbols =; MGC70609; VEGF; VEGF-A; VPF
| OMIM = 192240
| ECnumber =
| Homologene = 2534
| MGIid = 103178
| GeneAtlas_image =
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001570 |text = vasculogenesis}} {{GNF_GO|id=GO:0001666 |text = response to hypoxia}} {{GNF_GO|id=GO:0005172 |text = vascular endothelial growth factor receptor binding}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007498 |text = mesoderm development}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016477 |text = cell migration}} {{GNF_GO|id=GO:0030324 |text = lung development}} {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}} {{GNF_GO|id=GO:0030949 |text = positive regulation of vascular endothelial growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0042462 |text = eye photoreceptor cell development}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0050679 |text = positive regulation of epithelial cell proliferation}} {{GNF_GO|id=GO:0050840 |text = extracellular matrix binding}} {{GNF_GO|id=GO:0050930 |text = induction of positive chemotaxis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7422
| Hs_Ensembl = ENSG00000112715
| Hs_RefseqProtein = NP_001020537
| Hs_RefseqmRNA = NM_001025366
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 43845924
| Hs_GenLoc_end = 43862202
| Hs_Uniprot = P15692
| Mm_EntrezGene = 22339
| Mm_Ensembl = ENSMUSG00000023951
| Mm_RefseqmRNA = NM_001025250
| Mm_RefseqProtein = NP_001020421
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 45480574
| Mm_GenLoc_end = 45495331
| Mm_Uniprot =
}}
}}
<!-- BOT: SUMMARY BEGIN UPDATE = YES - This summary is automatically updated by protein box bot. Change the update option to NO to have the bot skip updating this summary -->
==Summary==
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternate transcriptional splice variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.
<!-- BOT: SUMMARY END -->
end log.
