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IL2-inducible T-cell kinase
Image source: 1SNX
Available structures: 1SNX, 2ETZ, 2EU0, 1LUK, 1LUM, 1LUN, 1LUI, 1AWJ, 1SNU, 1SM2
Identifiers
Symbol(s)	ITK; EMT; LYK; PSCTK2; MGC126257; MGC126258
External IDs	OMIM: 186973 MGI: 96621 HomoloGene: 4051
Gene Ontology Function: • Nucleotide binding • Non-membrane spanning protein tyrosine kinase activity • ATP binding Component: • Protein amino acid phosphorylation • Cellular defense response • Intracellular signaling cascade • Zinc ion binding Process: • Nucleotide binding • Non-membrane spanning protein tyrosine kinase activity • ATP binding • Protein amino acid phosphorylation • Cellular defense response • Intracellular signaling cascade • Zinc ion binding • Kinase activity • Transferase activity • Metal ion binding
Expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3702	16428
Ensembl	ENSG00000113263	ENSMUSG00000020395
Uniprot	Q08881	Q03526
Refseq	NM_005546 (mRNA) NP_005537 (protein)	NM_010583 (mRNA) NP_034713 (protein)
Location	Chr 5: 156.54 - 156.62 Mb	Chr 11: 46.28 - 46.35 Mb
Pubmed search	[1]	[2]

The ITK gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains SH2, SH3 and PH domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. ^[1]

[edit] References

1. ^ Entrez Gene