Talk:Inflammation

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Article Grading: The following comments were left by the quality and importance raters: (edit · history · refresh · how to use this template)

  • Requires far more reference diversity than just Robbins for an A-class grading I think -- Serephine ♠ talk - 09:44, 30 May 2007 (UTC)
To-do list for Inflammation: edit · history · watch · refresh
  • Information on leukocyte involvement (extravasation, chemotaxis, activation, phagocytosis, extracellular release of products)
  • Haemodynamics of inflammation
    • Diagram of vascular changes
  • Disorders of inflammation
  • Termination of inflammation
  • Morphologic patterns of inflammation (serous, fibrinous, purulent, ulceritive, granulomatous)
  • Involvement of lymphatic system
  • More references needed
  • Inflammation and allergy

Contents

[edit] Some General Concerns and Suggestions

This article needs to be strengthened in a lot of different ways including simply conceptually. First of all, the evidence is now virtually overwhelming that every disease of aging (Alzheimer's disease, cancer, heart disease, diabetes, arthritis, etc. etc.) is associated with long-term damage done by our own immune systems. For example, there is now solid evidence that the transition from mild cognitive impairment to dementia in patients with Alzheimer's disease is associated with up regulation of various cytokines systems, although it is not so clear what is driving this. There is also enormous evidence that cancer is associated with long-term inflammatory damage to various cell populations. heart disease is clearly associated with inflammatory processes on the arterial wall (in the context of oxidized lipids) enabling plaque formation. I don't think that any reasonable treatment of inflammation can fail to emphasize all these basic linkages and still claim to be remotely comprehensive. additionally, any treatment of the subject would have to at least link to a page on cytokines, which appear to come in both anti-and pro-inflammatory forms. The treatment here also fails to emphasize the relationship between stress and inflammation, between sleep deprivation and inflammation, and between depression and inflammation, as there is increasing evidence that depression is in part mediated by elevated cytokines. Additionally, treatment fails to mention numerous diseases that may involve dysregulation of inflammatory pathways and cytokines including particularly IBS, fibromyalgia, and chronic fatigue syndrome. There is also no principled discussion of anti-inflammatory drugs or anti-inflammatory foods, and there is more and more evidence that omega-3 supplementation is valuable because it reduces systemic inflammation (the omega-3 pathway competes with the omega six pathway for the same enzymes, and the omega six pathway promotes prostaglandins and other pro-inflammatory molecules.) Clearly there are a lot of things that could be improved here, but I would start with an emphasis on how the immune system cuts both ways, it clearly is essential for our survival, but its chronic overactivity may contribute hugely to diseases of aging and even to aging itself. This potentially makes the topic a lot richer and a lot more interesting. Indeed it looks like one of the critical ways to prevent many of the diseases of aging is to keep the immune system under control by ensuring a good nights sleep, regular exercise, and an anti-inflammatory diet. DFW Harvard Medical School. —Preceding unsigned comment added by 67.110.143.19 (talk) 18:41, 24 April 2008 (UTC)

[edit] Fifth cardinal sign

In the textbook Pathophysiology: Concepts of altered health states (7th edition) by Porth it says that the 5th cardinal sign "loss of function" was added by Galen in the 2nd century AD, not in the 19th century by Ahmed Abou Samra. Google searches containing one name and the term "loss of function" or the latin "functio laesa" seem to indicate that porth was correct. It also says that Celsus termed the first four signs in the 1st century AD if that helps anyone at all.58.170.163.218 (talk) 12:21, 9 April 2008 (UTC)

[edit] Systemic inflammation

The bit about systemic inflammation is intrigueing, twood be nice to have a page on it! Wblakesx 19:11, 18 March 2007 (UTC)wblakesx

[edit] Advertisment

I removed a bit of advertising text that seems to have been maliciously inserted. The text was "See www.softecare.com for information on anti-inflammation Soft-E-Lotion" Jwinget 18:37, 5 September 2006 (UTC)

[edit] Anti-inflammatory foods

I am interested to know what people think about the idea of Anti-Inflammatory foods. It seems to be a topic that is coming up more and more (see: Hello Anti-inflammatory foods, List of Anti-inflammatory foods). Is there a good scientific basis for this?

I was also curious about this. There doesn't seem to be any scientific basis for what the woman is saying in the referenced article. It's unfortunately that such an important subject like nutrition is flooded with all sorts of cult theories. DonPMitchell 19:53, 29 April 2007 (UTC)

[edit] Chronic inflammation merge

I would keep acute and chronic together, with specifics on chronic inflammatory disease issues in the relevent articles, give a chance for contrasting acute and Chronic in the same article. Steve Kd4ttc 14:46, 6 Jun 2004 (UTC)

[edit] question

Shouldn't NSAIDS (Nonsteriodal Anti-Inflammatory Drugs) at least be mentioned in this artical? I was researching different medicines and was curious about what exactly "inflammation" was as targeted by aspirin, ibuprofen, and other NSAIDS, but i didn't see anything about them in this artical so i was skeptical to whether this is the same inflammation that is targeted by such drugs. I am not a professional in the field, but i wish someone would, if this is the same inflammation, at least mention NSAIDS such as aspirin or ibuprofen as possible treatments for inflammation.


Hope this will answer your question: NSAIDs are COX inhibitors that inhibit the enzyme cyclooxygenase from transforming arachidonic acid (a derivative of cell membrane phospholipids) to prostaglandins. The prostaglandin family contributes to an inflammatory response mainly by increasing vasodilatation and vascular permeability. If the formation of the different arachidonic acid metabolites in the prostaglandin family is inhibited, some of the cardinal signs of inflammation might be decreased. Use of COX inhibitors, such as aspirin, will also decrease the ability of platelets to adhese and form a primary clot (see hemostasis and coagulation for more info on the formation of a blood clot) This is because COX inhibitors inhibit the formation of thromboxane (TXA2) in platelets. When used excessively, most NSAIDs might predispose to gastric ulceration by inhibiting COX-1. Some of the prostaglandins produced in the cyclooxygenase pathway are essencial for the protection against acid induced damage of the gastric mucosa and by inhibiting COX-1, the production of these metabolites is decreased. Recently, selective COX-2 inhibitors have been developped, obliterating the harmful effects of the COX-1 inhibitors on the gastric mucosa. However recent studies have shown that these drugs might lead to acute coronary artery disease.

Yours Sincerely

Helge-André Flakk Norwegian Dentist

 —Preceding unsigned comment added by 194.54.110.98 (talk) 21:47, 24 April 2008 (UTC)

[edit] The pictures are disgusting!

it is very hard to watch them.. do something... GOER 11:52, 21 July 2007 (UTC)

If you find these pictures hard to digest then I am not sure why you are viewing a pathology site. These images go hand in hand with the pathological outcomes of inflammation. 09:02 20 August 2007. —The preceding unsigned comment was added by 203.34.164.71 (talk) 23:03:10, August 19, 2007 (UTC)

I agree with the reply, the pictures are part of the topic. In fact there are not enough disgusting pictures. It is a pity decent photographs are so hard to come by. FQ1513 (talk) 23:29, 22 December 2007 (UTC)

[edit] Need Help

I have started a new page called inflammatory diseases of unknown etiology and would like some help answering these questions: What are the inflammatory diseases of unknown etiology? How many of them are there? What are the most common inflammatory diseases of unknown etiology? What kind of inflammation is associated with inflammatory diseases of unknown etiology? And how many kinds of inflammation patterns are there in inflammatory diseases of unknown etiology? If anyone has the time to contribute it would be appreciated. ReasonableLogicalMan(Talk 20:32, 18 November 2007 (UTC)

[edit] treatment options?

Shouldn't this page include a section on treatment options to be of service to those who suffer from chronic inflammatory conditions? FQ1513 (talk) 23:25, 22 December 2007 (UTC)

Not necessarily. Inflammation is a perfectly normal process. It doesn't necessarily need to be treated at all, and even when it does, the best treatment depends on the actual cause. A treatment section would basically boil down to "Inflammation normally goes away by itself, and when it doesn't, then you need to figure out the cause and treat the cause." A list of all possible treatments for all kinds of inflammation would be a mile long and basically useless. WhatamIdoing (talk) 19:45, 23 January 2008 (UTC)

[edit] pictures may detract from readability for some readers.

pictures may detract from readability for some readers. --Emesee (talk) 16:08, 25 January 2008 (UTC)

[edit] polymorphonuclear leukocytes

I don't believe the term "polymorphonuclear leukocytes" is used anywhere on the page as it is now. It might add to the page if the term was mentioned where appropriate. ReasonableLogicalMan(Talk 02:44, 26 February 2008 (UTC)